Q0TPN0 (Q0TPN0_CLOP1) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Acetate kinase 2 HAMAP MF_00020
EC=2.7.2.1 HAMAP MF_00020

Alternative name(s):
Acetokinase 2 HAMAP MF_00020

Gene names

Name:	ackA EMBL ABG82469.1
Synonyms:	ackA2 HAMAP MF_00020
Ordered Locus Names:	CPF_1977

Organism

Clostridium perfringens (strain ATCC 13124 / NCTC 8237 / Type A) [Complete proteome] [HAMAP]

Taxonomic identifier

195103 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Clostridia › Clostridiales › Clostridiaceae › Clostridium

Protein attributes

Sequence length	398 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + acetate = ADP + acetyl phosphate. HAMAP MF_00020 SAAS SAAS000890 ATP + propanoate = ADP + propanoyl phosphate. HAMAP MF_00020 SAAS SAAS000890
Pathway	Metabolic intermediate biosynthesis; acetyl-CoA biosynthesis; acetyl-CoA from acetate: step 1/2. HAMAP MF_00020
Subcellular location	Cytoplasm By similarity HAMAP MF_00020.
Sequence similarities	Belongs to the acetokinase family. HAMAP MF_00020 RuleBase RU003835

Ontologies

Keywords
Cellular component	Cytoplasm HAMAP MF_00020 SAAS SAAS000890
Ligand	ATP-binding HAMAP MF_00020 SAAS SAAS000890 Nucleotide-binding
Molecular function	Kinase HAMAP MF_00020 SAAS SAAS000890 RuleBase RU003835 EMBL ABG82469.1 Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	organic acid metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW acetate kinase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q0TPN0 [UniParc]. Last modified September 5, 2006. Version 1. Checksum: 7A224F71C9DF4CFD	FASTA	398	43,432
	10 20 30 40 50 60 MNVLVINCGS SSLKYQLIDM DTENALATGL VERIGLEGAN LTQKSEGKDK YEIVEPMKDH 70 80 90 100 110 120 QDAIRLVLGA LIDEKHGVIK SLDEINAIGH RVVHGGEKYA ESALVTEEVM KDLEECAKLA 130 140 150 160 170 180 PLHNPANIIG INACKALMPN VPMVVVFDTA FHQTMPEKAF VYALPYELYE KEHIRKYGFH 190 200 210 220 230 240 GTSHKYVSAK IAEAMGKNIE DLKIITCHLG NGASIAAIKN GKCVDTTMGF TPLEGLVMGT 250 260 270 280 290 300 RCGNIDPAVV TYLIDELGYT SQEVNTLMNK KSGIFGVSGV SSDFRDVEAA ADKGSKEAQI 310 320 330 340 350 360 ALDLFRNSVK KYIGAYIAEM NGCDVIVFTA GVGENSIIER GAICRDLEFL GIELDEERNN 370 380 390 IRAKVAEISK EGSRIKLFVV PTNEELMIAQ DTVSIISK

References

[1]

"Skewed genomic variability in strains of the toxigenic bacterial pathogen, Clostridium perfringens." Myers G.S.A., Rasko D.A., Cheung J.K., Ravel J., Seshadri R., DeBoy R.T., Ren Q., Varga J., Awad M.M., Brinkac L.M., Daugherty S.C., Haft D.H., Dodson R.J., Madupu R., Nelson W.C., Rosovitz M.J., Sullivan S.A., Khouri H. , Dimitrov G.I., Watkins K.L., Mulligan S., Benton J., Radune D., Fisher D.J., Atkins H.S., Hiscox T., Jost B.H., Billington S.J., Songer J.G., McClane B.A., Titball R.W., Rood J.I., Melville S.B., Paulsen I.T. Genome Res. 16:1031-1040(2006) [PubMed: 16825665] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000246 Genomic DNA. Translation: ABG82469.1.
RefSeq	YP_696410.1. NC_008261.1.
3D structure databases
ProteinModelPortal	Q0TPN0.
SMR	Q0TPN0. Positions 1-398.
ModBase	Search...
Protein-protein interaction databases
STRING	Q0TPN0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4202494.
GenomeReviews	Gene locus CPF_1977 in contig CP000246_GR.
KEGG	cpf:CPF_1977.
PATRIC	19486206. VBICloPer106549_1922.
TIGR	CPF_1977.
Phylogenomic databases
eggNOG	COG0282.
HOGENOM	HBG285863.
OMA	ERNNIRA.
ProtClustDB	PRK00180.
Family and domain databases
HAMAP	MF_00020. Acetate_kinase. [Tree]
InterPro	IPR004372. Ac/Proprionate_kinase. IPR000890. Aliphatic_acid_kin_short-chain. IPR023865. Aliphatic_acid_kinase_CS. [Graphical view]
KO	K00925.
PANTHER	PTHR21060. Acetate_kin. 1 hit.
Pfam	PF00871. Acetate_kinase. 1 hit. [Graphical view]
PIRSF	PIRSF000722. Acetate_prop_kin. 1 hit.
PRINTS	PR00471. ACETATEKNASE.
TIGRFAMs	TIGR00016. AckA. 1 hit.
PROSITE	PS01075. ACETATE_KINASE_1. 1 hit. PS01076. ACETATE_KINASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q0TPN0_CLOP1

Accession

Primary (citable) accession number: Q0TPN0

Entry history

Integrated into UniProtKB/TrEMBL:	September 5, 2006
Last sequence update:	September 5, 2006
Last modified:	January 25, 2012
This is version 45 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)