Q0TPI4 (URK_CLOP1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Uridine kinase
EC=2.7.1.48

Alternative name(s):
Cytidine monophosphokinase
Uridine monophosphokinase

Gene names

Name:	udk
Ordered Locus Names:	CPF_2023

Organism

Clostridium perfringens (strain ATCC 13124 / NCTC 8237 / Type A) [Complete proteome] [HAMAP]

Taxonomic identifier

195103 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Clostridia › Clostridiales › Clostridiaceae › Clostridium

Protein attributes

Sequence length	208 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + uridine = ADP + UMP. HAMAP MF_00551 ATP + cytidine = ADP + CMP. HAMAP MF_00551
Pathway	Pyrimidine metabolism; CTP biosynthesis via salvage pathway; CTP from cytidine: step 1/3. HAMAP MF_00551 Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uridine: step 1/1. HAMAP MF_00551
Subcellular location	Cytoplasm By similarity HAMAP MF_00551.
Sequence similarities	Belongs to the uridine kinase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW phosphotransferase activity, alcohol group as acceptor Inferred from electronic annotation. Source: InterPro uridine kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 208	208	Uridine kinase HAMAP MF_00551		PRO_1000017871
Regions
	Nucleotide binding	11 – 18	8	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	Q0TPI4 [UniParc]. Last modified September 5, 2006. Version 1. Checksum: 941BC368740DDE5E	FASTA	208	23,884
	10 20 30 40 50 60 MKRPIFIGIT GGTGSGKSTI AKEIYRQFGE DCIAMIEQDS YYKDQSHLSM EDRVKTNYDH 70 80 90 100 110 120 PNAFDNNLLV SHLESLLNGH SIQKPSYDFS IHNRIEDTTK VEPKEIVIVE GILILEDPRI 130 140 150 160 170 180 RELLDIKIYV DTDADVRIIR RMVRDINERG RTMESVINQY LNVVKPMHNQ FTEPTKKFAD 190 200 IIIPEGGHNK VAIDIIVAKI KEVLGKYE

References

[1]

"Skewed genomic variability in strains of the toxigenic bacterial pathogen, Clostridium perfringens." Myers G.S.A., Rasko D.A., Cheung J.K., Ravel J., Seshadri R., DeBoy R.T., Ren Q., Varga J., Awad M.M., Brinkac L.M., Daugherty S.C., Haft D.H., Dodson R.J., Madupu R., Nelson W.C., Rosovitz M.J., Sullivan S.A., Khouri H. , Dimitrov G.I., Watkins K.L., Mulligan S., Benton J., Radune D., Fisher D.J., Atkins H.S., Hiscox T., Jost B.H., Billington S.J., Songer J.G., McClane B.A., Titball R.W., Rood J.I., Melville S.B., Paulsen I.T. Genome Res. 16:1031-1040(2006) [PubMed: 16825665] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 13124 / NCTC 8237 / Type A.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000246 Genomic DNA. Translation: ABG84987.1.
RefSeq	YP_696456.1. NC_008261.1.
3D structure databases
ProteinModelPortal	Q0TPI4.
ModBase	Search...
Protein-protein interaction databases
STRING	Q0TPI4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4203237.
GenomeReviews	Gene locus CPF_2023 in contig CP000246_GR.
KEGG	cpf:CPF_2023.
PATRIC	19486298. VBICloPer106549_1968.
TIGR	CPF_2023.
Phylogenomic databases
eggNOG	COG0572.
HOGENOM	HBG527126.
OMA	NQFVEPT.
ProtClustDB	PRK05480.
Enzyme and pathway databases
BioCyc	CPER195103:CPF_2023-MONOMER.
Family and domain databases
HAMAP	MF_00551. Uridine_kinase. [Tree]
InterPro	IPR006083. PRK/URK. IPR000764. Uridine_kinase. [Graphical view]
KO	K00876.
Pfam	PF00485. PRK. 1 hit. [Graphical view]
PRINTS	PR00988. URIDINKINASE.
TIGRFAMs	TIGR00235. Udk. 1 hit.
ProtoNet	Search...

Entry information

Entry name

URK_CLOP1

Accession

Primary (citable) accession number: Q0TPI4

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	September 5, 2006
Last modified:	January 25, 2012
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program