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Protein

Ribosomal RNA small subunit methyltransferase H

Gene

rsmH

Organism
Clostridium perfringens (strain ATCC 13124 / DSM 756 / JCM 1290 / NCIMB 6125 / NCTC 8237 / Type A)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + cytosine(1402) in 16S rRNA = S-adenosyl-L-homocysteine + N(4)-methylcytosine(1402) in 16S rRNA.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei53S-adenosyl-L-methionineUniRule annotation1
Binding sitei83S-adenosyl-L-methionine; via amide nitrogenUniRule annotation1
Binding sitei100S-adenosyl-L-methionineUniRule annotation1
Binding sitei107S-adenosyl-L-methionineUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

rRNA processing

Keywords - Ligandi

S-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Ribosomal RNA small subunit methyltransferase HUniRule annotation (EC:2.1.1.199UniRule annotation)
Alternative name(s):
16S rRNA m(4)C1402 methyltransferaseUniRule annotation
rRNA (cytosine-N(4)-)-methyltransferase RsmHUniRule annotation
Gene namesi
Name:rsmHUniRule annotation
Synonyms:mraW
Ordered Locus Names:CPF_2119
OrganismiClostridium perfringens (strain ATCC 13124 / DSM 756 / JCM 1290 / NCIMB 6125 / NCTC 8237 / Type A)
Taxonomic identifieri195103 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
Proteomesi
  • UP000001823 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000628231 – 310Ribosomal RNA small subunit methyltransferase HAdd BLAST310

Interactioni

Protein-protein interaction databases

STRINGi195103.CPF_2119.

Structurei

3D structure databases

ProteinModelPortaliQ0TP92.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni33 – 35S-adenosyl-L-methionine bindingUniRule annotation3

Sequence similaritiesi

Belongs to the methyltransferase superfamily. RsmH family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CGJ. Bacteria.
COG0275. LUCA.
HOGENOMiHOG000049777.
KOiK03438.
OMAiNKKIHPA.
OrthoDBiPOG091H02LX.

Family and domain databases

Gene3Di1.10.150.170. 1 hit.
3.40.50.150. 2 hits.
HAMAPiMF_01007. 16SrRNA_methyltr_H. 1 hit.
InterProiIPR002903. RsmH.
IPR023397. SAM-dep_MeTrfase_MraW_recog.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PANTHERiPTHR11265. PTHR11265. 1 hit.
PfamiPF01795. Methyltransf_5. 1 hit.
[Graphical view]
PIRSFiPIRSF004486. MraW. 1 hit.
SUPFAMiSSF53335. SSF53335. 2 hits.
SSF81799. SSF81799. 1 hit.
TIGRFAMsiTIGR00006. TIGR00006. 1 hit.

Sequencei

Sequence statusi: Complete.

Q0TP92-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEFKHVSVLL DECINALNIK EDGIYVDCTL GGAGHSSEIV KRLSSDGRLI
60 70 80 90 100
GFDQDKDALK AAGERLKDYK NVTYVHSNFY AIYDVLTDLG IDGVDGILMD
110 120 130 140 150
LGVSSYQLDN GERGFSYMQD APLDMRMNRE NEFSAYEIVN TYSEEELYRI
160 170 180 190 200
IKEYGEEKFA KRIASFIVKN REEKNIETTL ELVEIIKAAI PAKARREGPH
210 220 230 240 250
PAKRTFQAIR IEVNKELEII SKTILDGVKK LNKGGRMAII TFHSLEDRIV
260 270 280 290 300
KNTFKELANP CTCPSEFPVC VCNRKPEVKL ISRKPIEASK EELEFNPRSR
310
SAKLRIIEKL
Length:310
Mass (Da):35,248
Last modified:September 5, 2006 - v1
Checksum:iE5D68D775402B407
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000246 Genomic DNA. Translation: ABG84157.1.
RefSeqiWP_003451137.1. NC_008261.1.

Genome annotation databases

EnsemblBacteriaiABG84157; ABG84157; CPF_2119.
KEGGicpf:CPF_2119.
PATRICi19486490. VBICloPer106549_2064.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000246 Genomic DNA. Translation: ABG84157.1.
RefSeqiWP_003451137.1. NC_008261.1.

3D structure databases

ProteinModelPortaliQ0TP92.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi195103.CPF_2119.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABG84157; ABG84157; CPF_2119.
KEGGicpf:CPF_2119.
PATRICi19486490. VBICloPer106549_2064.

Phylogenomic databases

eggNOGiENOG4105CGJ. Bacteria.
COG0275. LUCA.
HOGENOMiHOG000049777.
KOiK03438.
OMAiNKKIHPA.
OrthoDBiPOG091H02LX.

Family and domain databases

Gene3Di1.10.150.170. 1 hit.
3.40.50.150. 2 hits.
HAMAPiMF_01007. 16SrRNA_methyltr_H. 1 hit.
InterProiIPR002903. RsmH.
IPR023397. SAM-dep_MeTrfase_MraW_recog.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PANTHERiPTHR11265. PTHR11265. 1 hit.
PfamiPF01795. Methyltransf_5. 1 hit.
[Graphical view]
PIRSFiPIRSF004486. MraW. 1 hit.
SUPFAMiSSF53335. SSF53335. 2 hits.
SSF81799. SSF81799. 1 hit.
TIGRFAMsiTIGR00006. TIGR00006. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRSMH_CLOP1
AccessioniPrimary (citable) accession number: Q0TP92
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: September 5, 2006
Last modified: November 2, 2016
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.