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Protein

Anti-sigma F factor

Gene

spoIIAB

Organism
Clostridium perfringens (strain ATCC 13124 / DSM 756 / JCM 1290 / NCIMB 6125 / NCTC 8237 / Type A)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition.UniRule annotation

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

Sporulation

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCPER195103:GHAW-2320-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Anti-sigma F factorUniRule annotation (EC:2.7.11.1UniRule annotation)
Alternative name(s):
Stage II sporulation protein ABUniRule annotation
Gene namesi
Name:spoIIABUniRule annotation
Ordered Locus Names:CPF_2306
OrganismiClostridium perfringens (strain ATCC 13124 / DSM 756 / JCM 1290 / NCIMB 6125 / NCTC 8237 / Type A)
Taxonomic identifieri195103 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
Proteomesi
  • UP000001823 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 140140Anti-sigma F factorPRO_0000301412Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi195103.CPF_2306.

Structurei

3D structure databases

ProteinModelPortaliQ0TNR1.
SMRiQ0TNR1. Positions 1-138.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the anti-sigma-factor family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108ZBE. Bacteria.
COG2172. LUCA.
HOGENOMiHOG000269931.
KOiK06379.
OMAiHAYEDKI.
OrthoDBiPOG091H0LCB.

Family and domain databases

Gene3Di3.30.565.10. 1 hit.
HAMAPiMF_00637. Anti_sigma_F. 1 hit.
InterProiIPR010194. Anti-sigma_F.
IPR003594. HATPase_C.
[Graphical view]
PfamiPF13581. HATPase_c_2. 1 hit.
[Graphical view]
SMARTiSM00387. HATPase_c. 1 hit.
[Graphical view]
SUPFAMiSSF55874. SSF55874. 1 hit.
TIGRFAMsiTIGR01925. spIIAB. 1 hit.

Sequencei

Sequence statusi: Complete.

Q0TNR1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDNKMRLEFL AKSENEGFAR VSVSAFIAQL DPTIEELTDI KTAVSEAVTN
60 70 80 90 100
AIIHGYECDE SKVVIIEASI CEDEISITVE DNGIGIENLE EAREPLYTSK
110 120 130 140
PELERSGMGF TVMETFMDSL EVYSEKDKGT KIIMKKKMNT
Length:140
Mass (Da):15,666
Last modified:September 5, 2006 - v1
Checksum:iC8184B96CBF4B36D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000246 Genomic DNA. Translation: ABG85043.1.
RefSeqiWP_003451402.1. NC_008261.1.

Genome annotation databases

EnsemblBacteriaiABG85043; ABG85043; CPF_2306.
GeneIDi990364.
KEGGicpf:CPF_2306.
PATRICi19486864. VBICloPer106549_2245.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000246 Genomic DNA. Translation: ABG85043.1.
RefSeqiWP_003451402.1. NC_008261.1.

3D structure databases

ProteinModelPortaliQ0TNR1.
SMRiQ0TNR1. Positions 1-138.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi195103.CPF_2306.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABG85043; ABG85043; CPF_2306.
GeneIDi990364.
KEGGicpf:CPF_2306.
PATRICi19486864. VBICloPer106549_2245.

Phylogenomic databases

eggNOGiENOG4108ZBE. Bacteria.
COG2172. LUCA.
HOGENOMiHOG000269931.
KOiK06379.
OMAiHAYEDKI.
OrthoDBiPOG091H0LCB.

Enzyme and pathway databases

BioCyciCPER195103:GHAW-2320-MONOMER.

Family and domain databases

Gene3Di3.30.565.10. 1 hit.
HAMAPiMF_00637. Anti_sigma_F. 1 hit.
InterProiIPR010194. Anti-sigma_F.
IPR003594. HATPase_C.
[Graphical view]
PfamiPF13581. HATPase_c_2. 1 hit.
[Graphical view]
SMARTiSM00387. HATPase_c. 1 hit.
[Graphical view]
SUPFAMiSSF55874. SSF55874. 1 hit.
TIGRFAMsiTIGR01925. spIIAB. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiSP2AB_CLOP1
AccessioniPrimary (citable) accession number: Q0TNR1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: September 5, 2006
Last modified: September 7, 2016
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.