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Protein

Glutamate decarboxylase

Gene

CPF_2315

Organism
Clostridium perfringens (strain ATCC 13124 / NCTC 8237 / Type A)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

L-glutamate = 4-aminobutanoate + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

  1. glutamate decarboxylase activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glutamate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

DecarboxylaseUniRule annotation, Lyase

Keywords - Ligandi

Pyridoxal phosphateUniRule annotation

Enzyme and pathway databases

BioCyciCPER195103:GHAW-2329-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate decarboxylaseUniRule annotation (EC:4.1.1.15UniRule annotation)
Gene namesi
Ordered Locus Names:CPF_2315Imported
OrganismiClostridium perfringens (strain ATCC 13124 / NCTC 8237 / Type A)Imported
Taxonomic identifieri195103 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
ProteomesiUP000001823: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi195103.CPF_2315.

Structurei

3D structure databases

ProteinModelPortaliQ0TNQ2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the group II decarboxylase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0076.
HOGENOMiHOG000070228.
KOiK01580.
OMAiFVGTWMD.
OrthoDBiEOG6TFCPW.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
InterProiIPR010107. Glutamate_decarboxylase.
IPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11999:SF1. PTHR11999:SF1. 1 hit.
PfamiPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01788. Glu-decarb-GAD. 1 hit.

Sequencei

Sequence statusi: Complete.

Q0TNQ2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLFGKNELGS QFETPIFGTV ESNESIPKYE LAKKSIAPQV AYRLIKDDLL
60 70 80 90 100
DEGNARQNLC TFCQTYMDDE AVKLMAETLE KNAIDKSEYP QTTDLENRCV
110 120 130 140 150
NILADLWHAP KDESFMGTST VGSSEACMLG GMAMKFRWRN RAKALGMDVT
160 170 180 190 200
SRKPNLVISS GYQVCWEKFC VYWDIEMRLV PMDEEHMSIN VDKVLDYVDD
210 220 230 240 250
YTIGVVGILG ITYTGKYDDI KALDKKLEEY NKTAKLTVPM HIDAASGGMF
260 270 280 290 300
APFIEPELEW DFRLKNVVSI STSGHKYGLV YPGIGWVLWR DKEYLPQELV
310 320 330 340 350
FDVSYLGGKI PTMAINFSRS ASQIIGQYYN FLRYGFEGYR QIHQRTKDVA
360 370 380 390 400
MFLASELEKT GLFQIYNNGE NLPIVCYKLR DDVNVDWTLY DLADRLLMKG
410 420 430 440 450
WQVPAYPLPA DLQDTIIQRI VCRADLSHNL AELYLRDLKA AIEDLNNARV
460
LNQKSKTGVQ GFTH
Length:464
Mass (Da):52,940
Last modified:September 5, 2006 - v1
Checksum:i1B242027E4787DAE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000246 Genomic DNA. Translation: ABG82826.1.
RefSeqiYP_696738.1. NC_008261.1.

Genome annotation databases

EnsemblBacteriaiABG82826; ABG82826; CPF_2315.
GeneIDi4202384.
KEGGicpf:CPF_2315.
PATRICi19486882. VBICloPer106549_2254.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000246 Genomic DNA. Translation: ABG82826.1.
RefSeqiYP_696738.1. NC_008261.1.

3D structure databases

ProteinModelPortaliQ0TNQ2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi195103.CPF_2315.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABG82826; ABG82826; CPF_2315.
GeneIDi4202384.
KEGGicpf:CPF_2315.
PATRICi19486882. VBICloPer106549_2254.

Phylogenomic databases

eggNOGiCOG0076.
HOGENOMiHOG000070228.
KOiK01580.
OMAiFVGTWMD.
OrthoDBiEOG6TFCPW.

Enzyme and pathway databases

BioCyciCPER195103:GHAW-2329-MONOMER.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
InterProiIPR010107. Glutamate_decarboxylase.
IPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11999:SF1. PTHR11999:SF1. 1 hit.
PfamiPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01788. Glu-decarb-GAD. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 13124 / NCTC 8237 / Type AImported.

Entry informationi

Entry nameiQ0TNQ2_CLOP1
AccessioniPrimary (citable) accession number: Q0TNQ2
Entry historyi
Integrated into UniProtKB/TrEMBL: September 5, 2006
Last sequence update: September 5, 2006
Last modified: February 4, 2015
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.