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Protein

Butyrate kinase

Gene

buk

Organism
Clostridium perfringens (strain ATCC 13124 / DSM 756 / JCM 1290 / NCIMB 6125 / NCTC 8237 / Type A)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the conversion of butyryl-CoA through butyryl phosphate to butyrate.By similarity

Catalytic activityi

ATP + butanoate = ADP + butanoyl phosphate.

Pathwayi: butanoate metabolism

This protein is involved in the pathway butanoate metabolism, which is part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the pathway butanoate metabolism and in Lipid metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00863.

Names & Taxonomyi

Protein namesi
Recommended name:
Butyrate kinase (EC:2.7.2.7)
Short name:
BK
Gene namesi
Name:buk
Synonyms:bukA
Ordered Locus Names:CPF_2656
OrganismiClostridium perfringens (strain ATCC 13124 / DSM 756 / JCM 1290 / NCIMB 6125 / NCTC 8237 / Type A)
Taxonomic identifieri195103 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
Proteomesi
  • UP000001823 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002735801 – 356Butyrate kinaseAdd BLAST356

Interactioni

Protein-protein interaction databases

STRINGi195103.CPF_2656.

Structurei

3D structure databases

ProteinModelPortaliQ0TMV4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the acetokinase family.Curated

Phylogenomic databases

eggNOGiENOG4105CKM. Bacteria.
COG3426. LUCA.
HOGENOMiHOG000096659.
KOiK00929.
OMAiFRILTIN.
OrthoDBiPOG091H0JQ1.

Family and domain databases

HAMAPiMF_00542. Butyrate_kinase. 1 hit.
InterProiIPR000890. Aliphatic_acid_kin_short-chain.
IPR023865. Aliphatic_acid_kinase_CS.
IPR011245. Butyrate_kin.
[Graphical view]
PANTHERiPTHR21060. PTHR21060. 1 hit.
PTHR21060:SF3. PTHR21060:SF3. 1 hit.
PfamiPF00871. Acetate_kinase. 1 hit.
[Graphical view]
PIRSFiPIRSF036458. Butyrate_kin. 1 hit.
PRINTSiPR00471. ACETATEKNASE.
TIGRFAMsiTIGR02707. butyr_kinase. 1 hit.
PROSITEiPS01075. ACETATE_KINASE_1. 1 hit.
PS01076. ACETATE_KINASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q0TMV4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAYKLLIINP GSTSTKIGVY EGEKEILEET LRHSAEEILK YDTIFDQLDF
60 70 80 90 100
RKEVILKVLK EKGIDINELD AVVGRGGMLK PIEGGTYEVN EAMVEDLKIG
110 120 130 140 150
VQGPHASNLG GILSNEIAKE IGKRAFIVDP VVVDEMEDVA RLSGVPELPR
160 170 180 190 200
KSKFHALNQK AVAKRYAKEH NTSYEDVNLI VVHMGGGVSV GAHRKGRVID
210 220 230 240 250
VNNALDGDGP FSPERAGGVP SGELLEMCFS GKYSKEEVYK KLVGKGGFVA
260 270 280 290 300
YANTNDARDL IKLSQEGDEK GSLIFNAFIY QIAKEIGSMA VVLDGEVDAI
310 320 330 340 350
VLTGGIAYSD YVTNAINKKV KWIAPMVVYG GEDELLALAQ GAIRVLDGVE

EAKIYK
Length:356
Mass (Da):38,703
Last modified:September 5, 2006 - v1
Checksum:i43D4FBAC1032D87F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB016775 Genomic DNA. Translation: BAA74725.1.
AB035092 Genomic DNA. Translation: BAA95935.1.
CP000246 Genomic DNA. Translation: ABG83930.1.
RefSeqiWP_003454444.1. NC_008261.1.

Genome annotation databases

EnsemblBacteriaiABG83930; ABG83930; CPF_2656.
KEGGicpf:CPF_2656.
PATRICi19487564. VBICloPer106549_2551.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB016775 Genomic DNA. Translation: BAA74725.1.
AB035092 Genomic DNA. Translation: BAA95935.1.
CP000246 Genomic DNA. Translation: ABG83930.1.
RefSeqiWP_003454444.1. NC_008261.1.

3D structure databases

ProteinModelPortaliQ0TMV4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi195103.CPF_2656.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABG83930; ABG83930; CPF_2656.
KEGGicpf:CPF_2656.
PATRICi19487564. VBICloPer106549_2551.

Phylogenomic databases

eggNOGiENOG4105CKM. Bacteria.
COG3426. LUCA.
HOGENOMiHOG000096659.
KOiK00929.
OMAiFRILTIN.
OrthoDBiPOG091H0JQ1.

Enzyme and pathway databases

UniPathwayiUPA00863.

Family and domain databases

HAMAPiMF_00542. Butyrate_kinase. 1 hit.
InterProiIPR000890. Aliphatic_acid_kin_short-chain.
IPR023865. Aliphatic_acid_kinase_CS.
IPR011245. Butyrate_kin.
[Graphical view]
PANTHERiPTHR21060. PTHR21060. 1 hit.
PTHR21060:SF3. PTHR21060:SF3. 1 hit.
PfamiPF00871. Acetate_kinase. 1 hit.
[Graphical view]
PIRSFiPIRSF036458. Butyrate_kin. 1 hit.
PRINTSiPR00471. ACETATEKNASE.
TIGRFAMsiTIGR02707. butyr_kinase. 1 hit.
PROSITEiPS01075. ACETATE_KINASE_1. 1 hit.
PS01076. ACETATE_KINASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBUK_CLOP1
AccessioniPrimary (citable) accession number: Q0TMV4
Secondary accession number(s): Q9ZNE5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: September 5, 2006
Last modified: November 2, 2016
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.