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Q0TMM4

- SYC_CLOP1

UniProt

Q0TMM4 - SYC_CLOP1

Protein

Cysteine--tRNA ligase

Gene

cysS

Organism
Clostridium perfringens (strain ATCC 13124 / NCTC 8237 / Type A)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 61 (01 Oct 2014)
      Sequence version 1 (05 Sep 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-cysteine + tRNA(Cys) = AMP + diphosphate + L-cysteinyl-tRNA(Cys).UniRule annotation

    Cofactori

    Binds 1 zinc ion per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi28 – 281ZincUniRule annotation
    Metal bindingi208 – 2081ZincUniRule annotation
    Metal bindingi233 – 2331ZincUniRule annotation
    Metal bindingi237 – 2371ZincUniRule annotation
    Binding sitei268 – 2681ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. cysteine-tRNA ligase activity Source: UniProtKB-HAMAP
    3. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. cysteinyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Metal-binding, Nucleotide-binding, Zinc

    Enzyme and pathway databases

    BioCyciCPER195103:GHAW-2754-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cysteine--tRNA ligaseUniRule annotation (EC:6.1.1.16UniRule annotation)
    Alternative name(s):
    Cysteinyl-tRNA synthetaseUniRule annotation
    Short name:
    CysRSUniRule annotation
    Gene namesi
    Name:cysSUniRule annotation
    Ordered Locus Names:CPF_2737
    OrganismiClostridium perfringens (strain ATCC 13124 / NCTC 8237 / Type A)
    Taxonomic identifieri195103 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
    ProteomesiUP000001823: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 466466Cysteine--tRNA ligasePRO_0000332806Add
    BLAST

    Interactioni

    Subunit structurei

    Monomer.UniRule annotation

    Protein-protein interaction databases

    STRINGi195103.CPF_2737.

    Structurei

    3D structure databases

    ProteinModelPortaliQ0TMM4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi30 – 4011"HIGH" regionAdd
    BLAST
    Motifi265 – 2695"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0215.
    HOGENOMiHOG000245250.
    KOiK01883.
    OMAiMHADFDA.
    OrthoDBiEOG6RVFXC.

    Family and domain databases

    Gene3Di3.40.50.620. 1 hit.
    HAMAPiMF_00041. Cys_tRNA_synth.
    InterProiIPR015803. Cys-tRNA-ligase.
    IPR015273. Cys-tRNA-synt_Ia_DALR.
    IPR024909. Cys-tRNA/MSH_ligase.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    [Graphical view]
    PANTHERiPTHR10890. PTHR10890. 1 hit.
    PfamiPF09190. DALR_2. 1 hit.
    PF01406. tRNA-synt_1e. 1 hit.
    [Graphical view]
    PRINTSiPR00983. TRNASYNTHCYS.
    SMARTiSM00840. DALR_2. 1 hit.
    [Graphical view]
    SUPFAMiSSF47323. SSF47323. 1 hit.
    TIGRFAMsiTIGR00435. cysS. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q0TMM4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIKVYNTLNK KKEEFIPLTP GEVKMYVCGP TVYNFFHIGN GRTFIVFDTI    50
    RRYFEYRGFK VDFVQNFTDI DDKMIKKANE EGTTVKKIGD TYIKEYYQDA 100
    DALNIERATV NPRATEFIGE IIKFVKGLVD KGYAYEVDGD VYFSTKKFEG 150
    YGKLSGQNIE DLQSGARISV DERKKDPMDF AIWKAQKPGE PAWNSPWGMG 200
    RPGWHIECSC MAKKLLGETI DIHAGGSDLK FPHHENEIAQ SEALTGEPFA 250
    RYWLHSAFVN VNNEKMSKSL NNFFTAREIL ERYDADVIRF LMLSAHYRQQ 300
    LNFSEDLLES AKASVERIYN AIGNLENLID EVSREEMNEE EKAYLESLNK 350
    YKEKYIEKMD DDFNTADAIT AIFDLIKDTN TNITIDSSKE LAQKALELIR 400
    ELGAPLGMFQ KSTKGNLEEE IEALIAKRQQ ARKDRDFTLA DKIRDELKDR 450
    GIVLEDTPQG VRWKMI 466
    Length:466
    Mass (Da):53,680
    Last modified:September 5, 2006 - v1
    Checksum:iB58F719D3F0E3220
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000246 Genomic DNA. Translation: ABG83340.1.
    RefSeqiYP_697116.1. NC_008261.1.

    Genome annotation databases

    EnsemblBacteriaiABG83340; ABG83340; CPF_2737.
    GeneIDi4203390.
    KEGGicpf:CPF_2737.
    PATRICi19487726. VBICloPer106549_2631.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000246 Genomic DNA. Translation: ABG83340.1 .
    RefSeqi YP_697116.1. NC_008261.1.

    3D structure databases

    ProteinModelPortali Q0TMM4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 195103.CPF_2737.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABG83340 ; ABG83340 ; CPF_2737 .
    GeneIDi 4203390.
    KEGGi cpf:CPF_2737.
    PATRICi 19487726. VBICloPer106549_2631.

    Phylogenomic databases

    eggNOGi COG0215.
    HOGENOMi HOG000245250.
    KOi K01883.
    OMAi MHADFDA.
    OrthoDBi EOG6RVFXC.

    Enzyme and pathway databases

    BioCyci CPER195103:GHAW-2754-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.620. 1 hit.
    HAMAPi MF_00041. Cys_tRNA_synth.
    InterProi IPR015803. Cys-tRNA-ligase.
    IPR015273. Cys-tRNA-synt_Ia_DALR.
    IPR024909. Cys-tRNA/MSH_ligase.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    [Graphical view ]
    PANTHERi PTHR10890. PTHR10890. 1 hit.
    Pfami PF09190. DALR_2. 1 hit.
    PF01406. tRNA-synt_1e. 1 hit.
    [Graphical view ]
    PRINTSi PR00983. TRNASYNTHCYS.
    SMARTi SM00840. DALR_2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47323. SSF47323. 1 hit.
    TIGRFAMsi TIGR00435. cysS. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 13124 / NCTC 8237 / Type A.

    Entry informationi

    Entry nameiSYC_CLOP1
    AccessioniPrimary (citable) accession number: Q0TMM4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 29, 2008
    Last sequence update: September 5, 2006
    Last modified: October 1, 2014
    This is version 61 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3