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Q0TMM4

- SYC_CLOP1

UniProt

Q0TMM4 - SYC_CLOP1

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Protein
Cysteine--tRNA ligase
Gene
cysS, CPF_2737
Organism
Clostridium perfringens (strain ATCC 13124 / NCTC 8237 / Type A)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-cysteine + tRNA(Cys) = AMP + diphosphate + L-cysteinyl-tRNA(Cys).UniRule annotation

Cofactori

Binds 1 zinc ion per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi28 – 281Zinc By similarity
Metal bindingi208 – 2081Zinc By similarity
Metal bindingi233 – 2331Zinc By similarity
Metal bindingi237 – 2371Zinc By similarity
Binding sitei268 – 2681ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. cysteine-tRNA ligase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. cysteinyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

BioCyciCPER195103:GHAW-2754-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Cysteine--tRNA ligase (EC:6.1.1.16)
Alternative name(s):
Cysteinyl-tRNA synthetase
Short name:
CysRS
Gene namesi
Name:cysS
Ordered Locus Names:CPF_2737
OrganismiClostridium perfringens (strain ATCC 13124 / NCTC 8237 / Type A)
Taxonomic identifieri195103 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
ProteomesiUP000001823: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 466466Cysteine--tRNA ligaseUniRule annotation
PRO_0000332806Add
BLAST

Interactioni

Subunit structurei

Monomer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi195103.CPF_2737.

Structurei

3D structure databases

ProteinModelPortaliQ0TMM4.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi30 – 4011"HIGH" regionUniRule annotation
Add
BLAST
Motifi265 – 2695"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0215.
HOGENOMiHOG000245250.
KOiK01883.
OMAiMHADFDA.
OrthoDBiEOG6RVFXC.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_00041. Cys_tRNA_synth.
InterProiIPR015803. Cys-tRNA-ligase.
IPR015273. Cys-tRNA-synt_Ia_DALR.
IPR024909. Cys-tRNA/MSH_ligase.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view]
PANTHERiPTHR10890. PTHR10890. 1 hit.
PfamiPF09190. DALR_2. 1 hit.
PF01406. tRNA-synt_1e. 1 hit.
[Graphical view]
PRINTSiPR00983. TRNASYNTHCYS.
SMARTiSM00840. DALR_2. 1 hit.
[Graphical view]
SUPFAMiSSF47323. SSF47323. 1 hit.
TIGRFAMsiTIGR00435. cysS. 1 hit.

Sequencei

Sequence statusi: Complete.

Q0TMM4-1 [UniParc]FASTAAdd to Basket

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MIKVYNTLNK KKEEFIPLTP GEVKMYVCGP TVYNFFHIGN GRTFIVFDTI    50
RRYFEYRGFK VDFVQNFTDI DDKMIKKANE EGTTVKKIGD TYIKEYYQDA 100
DALNIERATV NPRATEFIGE IIKFVKGLVD KGYAYEVDGD VYFSTKKFEG 150
YGKLSGQNIE DLQSGARISV DERKKDPMDF AIWKAQKPGE PAWNSPWGMG 200
RPGWHIECSC MAKKLLGETI DIHAGGSDLK FPHHENEIAQ SEALTGEPFA 250
RYWLHSAFVN VNNEKMSKSL NNFFTAREIL ERYDADVIRF LMLSAHYRQQ 300
LNFSEDLLES AKASVERIYN AIGNLENLID EVSREEMNEE EKAYLESLNK 350
YKEKYIEKMD DDFNTADAIT AIFDLIKDTN TNITIDSSKE LAQKALELIR 400
ELGAPLGMFQ KSTKGNLEEE IEALIAKRQQ ARKDRDFTLA DKIRDELKDR 450
GIVLEDTPQG VRWKMI 466
Length:466
Mass (Da):53,680
Last modified:September 5, 2006 - v1
Checksum:iB58F719D3F0E3220
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000246 Genomic DNA. Translation: ABG83340.1.
RefSeqiYP_697116.1. NC_008261.1.

Genome annotation databases

EnsemblBacteriaiABG83340; ABG83340; CPF_2737.
GeneIDi4203390.
KEGGicpf:CPF_2737.
PATRICi19487726. VBICloPer106549_2631.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000246 Genomic DNA. Translation: ABG83340.1 .
RefSeqi YP_697116.1. NC_008261.1.

3D structure databases

ProteinModelPortali Q0TMM4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 195103.CPF_2737.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABG83340 ; ABG83340 ; CPF_2737 .
GeneIDi 4203390.
KEGGi cpf:CPF_2737.
PATRICi 19487726. VBICloPer106549_2631.

Phylogenomic databases

eggNOGi COG0215.
HOGENOMi HOG000245250.
KOi K01883.
OMAi MHADFDA.
OrthoDBi EOG6RVFXC.

Enzyme and pathway databases

BioCyci CPER195103:GHAW-2754-MONOMER.

Family and domain databases

Gene3Di 3.40.50.620. 1 hit.
HAMAPi MF_00041. Cys_tRNA_synth.
InterProi IPR015803. Cys-tRNA-ligase.
IPR015273. Cys-tRNA-synt_Ia_DALR.
IPR024909. Cys-tRNA/MSH_ligase.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view ]
PANTHERi PTHR10890. PTHR10890. 1 hit.
Pfami PF09190. DALR_2. 1 hit.
PF01406. tRNA-synt_1e. 1 hit.
[Graphical view ]
PRINTSi PR00983. TRNASYNTHCYS.
SMARTi SM00840. DALR_2. 1 hit.
[Graphical view ]
SUPFAMi SSF47323. SSF47323. 1 hit.
TIGRFAMsi TIGR00435. cysS. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 13124 / NCTC 8237 / Type A.

Entry informationi

Entry nameiSYC_CLOP1
AccessioniPrimary (citable) accession number: Q0TMM4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: September 5, 2006
Last modified: May 14, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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