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Q0TMI3

- FTHS_CLOP1

UniProt

Q0TMI3 - FTHS_CLOP1

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Protein
Formate--tetrahydrofolate ligase
Gene
fhs, CPF_2785
Organism
Clostridium perfringens (strain ATCC 13124 / NCTC 8237 / Type A)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi65 – 728ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCPER195103:GHAW-2805-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligase (EC:6.3.4.3)
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name:
FHS
Short name:
FTHFS
Gene namesi
Name:fhs
Ordered Locus Names:CPF_2785
OrganismiClostridium perfringens (strain ATCC 13124 / NCTC 8237 / Type A)
Taxonomic identifieri195103 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
ProteomesiUP000001823: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 556556Formate--tetrahydrofolate ligaseUniRule annotation
PRO_0000300520Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi195103.CPF_2785.

Structurei

3D structure databases

ProteinModelPortaliQ0TMI3.
SMRiQ0TMI3. Positions 4-554.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiLKHHGGV.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q0TMI3-1 [UniParc]FASTAAdd to Basket

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MKNDIEIAQS AKMEPIINIA KKIGLGEDDI ELYGKYKCKI SLDAIKKLEN    50
NKDGKLVLVT AINPTPAGEG KSTVTVGLGQ ALNKIGKNTV IALREPSLGP 100
VFGIKGGAAG GGYAQVVPME DINLHFTGDM HAITSANNLL CAAIDNHIHQ 150
GNLLRIDSRR IVFKRVMDMN DRALRNIVVG MGGKINGFLR EDGFMITVAS 200
EIMAILCMAS DLEDLKERMG NILIAYNLDG EPVYAKELEV QGAMALLMKD 250
AIKPNLVQTL ENTPAIIHGG PFANIAHGCN SIIATKTALK MSDITITEAG 300
FGADLGAEKF LDIKCRYGNL NPDCVVLVAT IRALKHHGGV KKDELNISNV 350
DALNKGMKNL EKQIENIKAY GVPVVVAINK FITDSDEEVK AIEDFCKNIG 400
VEVSLTEVWE KGGEGGIDLA NKVIKTMETE PSNFKMIYDS EESINDKILK 450
IVQTIYGGKG VNYTPQALKQ IAEIEKFNLD KLPICMAKTQ YSLSDNPSLL 500
GRPENFDITV REVRVSNGAG FIVVLTGDVM TMPGLPKVPA ANRMDIKDNG 550
EIVGLF 556
Length:556
Mass (Da):60,267
Last modified:September 5, 2006 - v1
Checksum:i8A30172BAA24054E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000246 Genomic DNA. Translation: ABG83765.1.
RefSeqiYP_697157.1. NC_008261.1.

Genome annotation databases

EnsemblBacteriaiABG83765; ABG83765; CPF_2785.
GeneIDi4203898.
KEGGicpf:CPF_2785.
PATRICi19487830. VBICloPer106549_2673.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000246 Genomic DNA. Translation: ABG83765.1 .
RefSeqi YP_697157.1. NC_008261.1.

3D structure databases

ProteinModelPortali Q0TMI3.
SMRi Q0TMI3. Positions 4-554.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 195103.CPF_2785.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABG83765 ; ABG83765 ; CPF_2785 .
GeneIDi 4203898.
KEGGi cpf:CPF_2785.
PATRICi 19487830. VBICloPer106549_2673.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OMAi LKHHGGV.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci CPER195103:GHAW-2805-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 13124 / NCTC 8237 / Type A.

Entry informationi

Entry nameiFTHS_CLOP1
AccessioniPrimary (citable) accession number: Q0TMI3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: September 5, 2006
Last modified: May 14, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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