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Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Clostridium perfringens (strain ATCC 13124 / DSM 756 / JCM 1290 / NCIMB 6125 / NCTC 8237 / Type A)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi: tetrahydrofolate interconversion

This protein is involved in the pathway tetrahydrofolate interconversion, which is part of One-carbon metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway tetrahydrofolate interconversion and in One-carbon metabolism.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi65 – 72ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processOne-carbon metabolism
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCPER195103:G1G5R-2740-MONOMER
UniPathwayiUPA00193

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
Alternative name(s):
Formyltetrahydrofolate synthetaseUniRule annotation
Short name:
FHSUniRule annotation
Short name:
FTHFSUniRule annotation
Gene namesi
Name:fhsUniRule annotation
Ordered Locus Names:CPF_2785
OrganismiClostridium perfringens (strain ATCC 13124 / DSM 756 / JCM 1290 / NCIMB 6125 / NCTC 8237 / Type A)
Taxonomic identifieri195103 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
Proteomesi
  • UP000001823 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003005201 – 556Formate--tetrahydrofolate ligaseAdd BLAST556

Proteomic databases

PRIDEiQ0TMI3

Interactioni

Protein-protein interaction databases

STRINGi195103.CPF_2785

Structurei

3D structure databases

ProteinModelPortaliQ0TMI3
SMRiQ0TMI3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CKU Bacteria
COG2759 LUCA
HOGENOMiHOG000040280
KOiK01938
OMAiCGEIMTM
OrthoDBiPOG091H01S8

Family and domain databases

CDDicd00477 FTHFS, 1 hit
HAMAPiMF_01543 FTHFS, 1 hit
InterProiView protein in InterPro
IPR000559 Formate_THF_ligase
IPR020628 Formate_THF_ligase_CS
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF01268 FTHFS, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00721 FTHFS_1, 1 hit
PS00722 FTHFS_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q0TMI3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKNDIEIAQS AKMEPIINIA KKIGLGEDDI ELYGKYKCKI SLDAIKKLEN
60 70 80 90 100
NKDGKLVLVT AINPTPAGEG KSTVTVGLGQ ALNKIGKNTV IALREPSLGP
110 120 130 140 150
VFGIKGGAAG GGYAQVVPME DINLHFTGDM HAITSANNLL CAAIDNHIHQ
160 170 180 190 200
GNLLRIDSRR IVFKRVMDMN DRALRNIVVG MGGKINGFLR EDGFMITVAS
210 220 230 240 250
EIMAILCMAS DLEDLKERMG NILIAYNLDG EPVYAKELEV QGAMALLMKD
260 270 280 290 300
AIKPNLVQTL ENTPAIIHGG PFANIAHGCN SIIATKTALK MSDITITEAG
310 320 330 340 350
FGADLGAEKF LDIKCRYGNL NPDCVVLVAT IRALKHHGGV KKDELNISNV
360 370 380 390 400
DALNKGMKNL EKQIENIKAY GVPVVVAINK FITDSDEEVK AIEDFCKNIG
410 420 430 440 450
VEVSLTEVWE KGGEGGIDLA NKVIKTMETE PSNFKMIYDS EESINDKILK
460 470 480 490 500
IVQTIYGGKG VNYTPQALKQ IAEIEKFNLD KLPICMAKTQ YSLSDNPSLL
510 520 530 540 550
GRPENFDITV REVRVSNGAG FIVVLTGDVM TMPGLPKVPA ANRMDIKDNG

EIVGLF
Length:556
Mass (Da):60,267
Last modified:September 5, 2006 - v1
Checksum:i8A30172BAA24054E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000246 Genomic DNA Translation: ABG83765.1
RefSeqiWP_003470195.1, NC_008261.1

Genome annotation databases

EnsemblBacteriaiABG83765; ABG83765; CPF_2785
GeneIDi29570102
KEGGicpf:CPF_2785

Similar proteinsi

Entry informationi

Entry nameiFTHS_CLOP1
AccessioniPrimary (citable) accession number: Q0TMI3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: September 5, 2006
Last modified: May 23, 2018
This is version 72 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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