Reviewed, UniProtKB/Swiss-Prot Q0TME7 (ADD_CLOP1)

Names and origin

Protein names

Recommended name:
    Adenosine deaminase
    EC=3.5.4.4
Alternative name(s):
    Adenosine aminohydrolase

Gene names

Name:	add
Ordered Locus Names:	CPF_2829

Organism

Clostridium perfringens (strain ATCC 13124 / NCTC 8237 / Type A) [Complete proteome] [HAMAP]

Taxonomic identifier

195103 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Clostridia › Clostridiales › Clostridiaceae › Clostridium

Protein attributes

Sequence length	332 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Adenosine + H2O = inosine + NH3. HAMAP MF_00540
Sequence similarities	Belongs to the adenosine and AMP deaminases family.

Ontologies

Keywords
Biological process	Nucleotide metabolism
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	purine ribonucleoside monophosphate biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	adenosine deaminase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 332	332	Adenosine deaminase HAMAP MF_00540		PRO_1000017657
Sites
	Active site	197	1	Potential
	Active site	245	1	Potential
	Active site	278	1	Potential
	Active site	279	1	Potential

Sequences

	Sequence		Length	Mass (Da)
	Q0TME7-1 [UniParc]. Last modified September 5, 2006. Version 1. Checksum: B258426E6B19CB4C	FASTA	332	38,041
	10 20 30 40 50 60 MNLLNLPKIE LHCHLDGSLR VETAIELAKK EGVKLDSYEY DKVKELLVIP KECNSLEDYL 70 80 90 100 110 120 NRFALPVKLL QRAENLERVA FELMEDASKE NVKYIEIRFA PLLHLEKGMT QKEVIESVIK 130 140 150 160 170 180 GIRKAEELYD IKGNLILSCL RHHSIDSVYE VIEEGKNFIG KGVVAIDLAG GELENFVKPY 190 200 210 220 230 240 EEVMKLARKA GFRVTIHAGE TGYGKNVRDA IELLGAERIG HGLFIFNDEE AYNLVKEKGV 250 260 270 280 290 300 TLEMCPKSNI DTKGVNKYEE HPIYKYHKDN IKVNLSTDNR TVSNINLTEE FENVHKTFNI 310 320 330 DFEDYKKIYL NSVEASFCSE ELKEKLKLSI II

References

[1]

"Skewed genomic variability in strains of the toxigenic bacterial pathogen, Clostridium perfringens." Myers G.S.A., Rasko D.A., Cheung J.K., Ravel J., Seshadri R., DeBoy R.T., Ren Q., Varga J., Awad M.M., Brinkac L.M., Daugherty S.C., Haft D.H., Dodson R.J., Madupu R., Nelson W.C., Rosovitz M.J., Sullivan S.A., Khouri H. , Dimitrov G.I., Watkins K.L., Mulligan S., Benton J., Radune D., Fisher D.J., Atkins H.S., Hiscox T., Jost B.H., Billington S.J., Songer J.G., McClane B.A., Titball R.W., Rood J.I., Melville S.B., Paulsen I.T. Genome Res. 16:1031-1040(2006) [PubMed: 16825665] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000246 Genomic DNA. Translation: ABG82606.1.
RefSeq	YP_697193.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q0TME7.
Genome annotation databases
GeneID	4201385.
GenomeReviews	Gene locus CPF_2829 in contig CP000246_GR.
KEGG	cpf:CPF_2829.
TIGR	CPF_2829.
Phylogenomic databases
HOGENOM	Q0TME7.
OMA	GQNVYDA.
Family and domain databases
HAMAP	MF_00540. [Tree]
InterPro	IPR006650. A/AMP_deam_AS. IPR001365. A/AMP_deaminase. IPR006330. A_deaminase. [Graphical view]
PANTHER	PTHR11409. A/AMP_deaminase. 1 hit.
Pfam	PF00962. A_deaminase. 1 hit. [Graphical view]
TIGRFAMs	TIGR01430. aden_deam. 1 hit.
PROSITE	PS00485. A_DEAMINASE. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ADD_CLOP1

Accession

Primary (citable) accession number: Q0TME7

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	September 5, 2006
Last modified:	November 3, 2009
This is version 22 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)