Q0TM95 (COMB_CLOP1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable 2-phosphosulfolactate phosphatase
EC=3.1.3.71

Gene names

Name:	comB
Ordered Locus Names:	CPF_2881

Organism

Clostridium perfringens (strain ATCC 13124 / NCTC 8237 / Type A) [Complete proteome] [HAMAP]

Taxonomic identifier

195103 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Clostridia › Clostridiales › Clostridiaceae › Clostridium

Protein attributes

Sequence length	247 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	(2R)-2-phospho-3-sulfolactate + H2O = (2R)-3-sulfolactate + phosphate. HAMAP MF_00490
Cofactor	Magnesium By similarity. HAMAP MF_00490
Sequence similarities	Belongs to the ComB family.

Ontologies

Keywords
Ligand	Magnesium
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	coenzyme M biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	2-phosphosulfolactate phosphatase activity Inferred from electronic annotation. Source: EC magnesium ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 247	247	Probable 2-phosphosulfolactate phosphatase HAMAP MF_00490		PRO_1000014463

Sequences

	Sequence		Length	Mass (Da)
	Q0TM95 [UniParc]. Last modified September 5, 2006. Version 1. Checksum: CDD05C763E9FC598	FASTA	247	27,221
	10 20 30 40 50 60 MKIDVIISAD YIDSEALKGK IAVVIDMLRA TSVITTALYN GAKKVIPVVS VEEAFEKAKE 70 80 90 100 110 120 LKSLGEEVLL GGERKALKID GFDFSNSPLE YKREIVEGKN VIMSTTNGTR ALNLCSKADK 130 140 150 160 170 180 VIVASVLNGQ AVAKYLENEE KEIVFVNSGT NGEFSSDDFM CAGYIISELC KNKEAELTDI 190 200 210 220 230 240 AKTAKYVYES SEGIEEFIKD AKHYNILKNL GLEEDLKYCS TKNLIDLVFE FKNGEIKTVE SGVKVTI

References

[1]

"Skewed genomic variability in strains of the toxigenic bacterial pathogen, Clostridium perfringens." Myers G.S.A., Rasko D.A., Cheung J.K., Ravel J., Seshadri R., DeBoy R.T., Ren Q., Varga J., Awad M.M., Brinkac L.M., Daugherty S.C., Haft D.H., Dodson R.J., Madupu R., Nelson W.C., Rosovitz M.J., Sullivan S.A., Khouri H. , Dimitrov G.I., Watkins K.L., Mulligan S., Benton J., Radune D., Fisher D.J., Atkins H.S., Hiscox T., Jost B.H., Billington S.J., Songer J.G., McClane B.A., Titball R.W., Rood J.I., Melville S.B., Paulsen I.T. Genome Res. 16:1031-1040(2006) [PubMed: 16825665] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 13124 / NCTC 8237 / Type A.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000246 Genomic DNA. Translation: ABG85008.1.
RefSeq	YP_697245.1. NC_008261.1.
3D structure databases
ProteinModelPortal	Q0TM95.
SMR	Q0TM95. Positions 1-236.
ModBase	Search...
Protein-protein interaction databases
STRING	Q0TM95.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4203455.
GenomeReviews	Gene locus CPF_2881 in contig CP000246_GR.
KEGG	cpf:CPF_2881.
PATRIC	19488020. VBICloPer106549_2761.
TIGR	CPF_2881.
Phylogenomic databases
eggNOG	COG2045.
HOGENOM	HBG633644.
OMA	VPCHREN.
ProtClustDB	PRK00886.
Enzyme and pathway databases
BioCyc	CPER195103:CPF_2881-MONOMER.
Family and domain databases
HAMAP	MF_00490. ComB. [Tree]
InterPro	IPR005238. 2-PSlactate_phosphatase. IPR022995. Pase_ComB. [Graphical view]
Gene3D	G3DSA:3.90.1560.10. 2-PSlactate_phosphatase. 1 hit.
KO	K05979.
Pfam	PF04029. 2-ph_phosp. 1 hit. [Graphical view]
SUPFAM	SSF142823. SSF142823. 1 hit.
ProtoNet	Search...

Entry information

Entry name

COMB_CLOP1

Accession

Primary (citable) accession number: Q0TM95

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	September 5, 2006
Last modified:	January 25, 2012
This is version 32 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program