Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Probable crotonobetaine/carnitine-CoA ligase

Gene

caiC

Organism
Escherichia coli O6:K15:H31 (strain 536 / UPEC)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Could catalyze the transfer of CoA to carnitine, generating the initial carnitinyl-CoA needed for the CaiB reaction cycle.UniRule annotation

Pathwayi: carnitine metabolism

This protein is involved in the pathway carnitine metabolism, which is part of Amine and polyamine metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway carnitine metabolism and in Amine and polyamine metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Enzyme and pathway databases

BioCyciECOL362663:GIY5-36-MONOMER.
UniPathwayiUPA00117.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable crotonobetaine/carnitine-CoA ligaseUniRule annotation (EC:6.2.1.-UniRule annotation)
Gene namesi
Name:caiCUniRule annotation
Ordered Locus Names:ECP_0037
OrganismiEscherichia coli O6:K15:H31 (strain 536 / UPEC)
Taxonomic identifieri362663 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 517517Probable crotonobetaine/carnitine-CoA ligasePRO_0000298681Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi362663.ECP_0037.

Structurei

3D structure databases

ProteinModelPortaliQ0TLV2.
SMRiQ0TLV2. Positions 2-517.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent AMP-binding enzyme family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CEY. Bacteria.
COG0318. LUCA.
HOGENOMiHOG000230001.
KOiK02182.
OMAiTALIYES.

Family and domain databases

HAMAPiMF_01524. CaiC. 1 hit.
InterProiIPR025110. AMP-bd_C.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
IPR023456. CaiC.
[Graphical view]
PfamiPF00501. AMP-binding. 1 hit.
PF13193. AMP-binding_C. 1 hit.
[Graphical view]
PROSITEiPS00455. AMP_BINDING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q0TLV2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDIIGGQHLR QMWDDLADVY GHKTALICES SSGVVNRYSY LELNQEINRT
60 70 80 90 100
ANLFYTLGIR KGDKVALHLD NCPEFIFCWF GLAKIGAIMV PINARLLREE
110 120 130 140 150
STWILQNSQA CLLVTSAQFY PMYQQIQQED ASQLRHICLT DMVLPADDGV
160 170 180 190 200
SSFTQLKNQQ PATLCYAPPL STDDTAEILF TSGTTSRPKG VVITHYNLRF
210 220 230 240 250
AGYYSAWQCA LRDDDVYLTV MPAFHIDCQC TAAMAAFSAG ATFVLVEKYS
260 270 280 290 300
ARAFWGQVQK YRATITECIP MMIRTLMVQP LSANDQQHRL REVMFYLNLS
310 320 330 340 350
EQEKDAFCER FSVRLLTSYG MTETIVGIIG DRPGDKRRWP SIGRAGFCYE
360 370 380 390 400
AEIRDDHNRP LPAGELGEIC IKGVPGKTIF KEYFLNPKAT AKVLEADGWL
410 420 430 440 450
HTGDTGYRDE EGFFYFVDRR CNMIKRGGEN VSCVELENII ATHPKIQDIV
460 470 480 490 500
VVGIKDSIRD EAIKAFVVLN EGETLSEEEF FCFCEQNMAK FKVPSYLEIR
510
KDLPRNCSGK IIRKNLK
Length:517
Mass (Da):58,655
Last modified:August 21, 2007 - v2
Checksum:iC66E32D6A3BD27F6
GO

Sequence cautioni

The sequence ABG68079 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000247 Genomic DNA. Translation: ABG68079.1. Different initiation.
RefSeqiWP_001298634.1. NC_008253.1.

Genome annotation databases

EnsemblBacteriaiABG68079; ABG68079; ECP_0037.
KEGGiecp:ECP_0037.
PATRICi18190711. VBIEscCol77757_0039.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000247 Genomic DNA. Translation: ABG68079.1. Different initiation.
RefSeqiWP_001298634.1. NC_008253.1.

3D structure databases

ProteinModelPortaliQ0TLV2.
SMRiQ0TLV2. Positions 2-517.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi362663.ECP_0037.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABG68079; ABG68079; ECP_0037.
KEGGiecp:ECP_0037.
PATRICi18190711. VBIEscCol77757_0039.

Phylogenomic databases

eggNOGiENOG4105CEY. Bacteria.
COG0318. LUCA.
HOGENOMiHOG000230001.
KOiK02182.
OMAiTALIYES.

Enzyme and pathway databases

UniPathwayiUPA00117.
BioCyciECOL362663:GIY5-36-MONOMER.

Family and domain databases

HAMAPiMF_01524. CaiC. 1 hit.
InterProiIPR025110. AMP-bd_C.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
IPR023456. CaiC.
[Graphical view]
PfamiPF00501. AMP-binding. 1 hit.
PF13193. AMP-binding_C. 1 hit.
[Graphical view]
PROSITEiPS00455. AMP_BINDING. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCAIC_ECOL5
AccessioniPrimary (citable) accession number: Q0TLV2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: August 21, 2007
Last modified: September 7, 2016
This is version 64 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.