Q0TLT8 (APAH_ECOL5) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Bis(5'-nucleosyl)-tetraphosphatase, symmetrical
EC=3.6.1.41

Alternative name(s):
Ap4A hydrolase
Diadenosine 5',5'''-P1,P4-tetraphosphate pyrophosphohydrolase
Diadenosine tetraphosphatase

Gene names

Name:	apaH
Ordered Locus Names:	ECP_0051

Organism

Escherichia coli O6:K15:H31 (strain 536 / UPEC) [Complete proteome] [HAMAP]

Taxonomic identifier

362663 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia

Protein attributes

Sequence length	282 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP By similarity. HAMAP MF_00199
Catalytic activity	P1,P(4)-bis(5'-adenosyl) tetraphosphate + H2O = 2 ADP. HAMAP MF_00199
Sequence similarities	Belongs to the Ap4A hydrolase family.

Ontologies

Keywords
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	bis(5'-nucleosyl)-tetraphosphatase (symmetrical) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 282	282	Bis(5'-nucleosyl)-tetraphosphatase, symmetrical HAMAP MF_00199		PRO_1000012058

Sequences

	Sequence		Length	Mass (Da)
	Q0TLT8 [UniParc]. Last modified September 5, 2006. Version 1. Checksum: 65075A157B1F9446	FASTA	282	31,568
	10 20 30 40 50 60 MATYLIGDVH GCYDELIALL HKVEFTPGKD TLWLTGDLVA RGPGSLDVLR YVKSLGDSVR 70 80 90 100 110 120 LVLGNHDLHL LAVFAGISRN KPKDRLTPLL EAPDADELLN WLRRQPLLQI DEEKKLVMAH 130 140 150 160 170 180 AGITPQWDLQ TAKECARDVE AVLSSDSYPF FLDAMYGDMP NNWSPELRGL GRLRFITNAF 190 200 210 220 230 240 TRMRFCFPNG QLDMYSKESP EEAPAPLKPW FAIPGPVAEE YNIAFGHWAS LEGKGTPEGI 250 260 270 280 YALDTGCCWG GTLTCLRWED KQYFVQPSNR HKDLSEGEAV AS

References

[1]

"Role of pathogenicity island-associated integrases in the genome plasticity of uropathogenic Escherichia coli strain 536." Hochhut B., Wilde C., Balling G., Middendorf B., Dobrindt U., Brzuszkiewicz E., Gottschalk G., Carniel E., Hacker J. Mol. Microbiol. 61:584-595(2006) [PubMed: 16879640] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 536 / UPEC.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000247 Genomic DNA. Translation: ABG68093.1.
RefSeq	YP_667992.1. NC_008253.1.
3D structure databases
ProteinModelPortal	Q0TLT8.
SMR	Q0TLT8. Positions 2-268.
ModBase	Search...
Protein-protein interaction databases
STRING	Q0TLT8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBESCT00000047669; EBESCP00000045858; EBESCG00000046719.
GeneID	4189957.
GenomeReviews	Gene locus ECP_0051 in contig CP000247_GR.
KEGG	ecp:ECP_0051.
NMPDR	fig|340197.3.peg.4234.
PATRIC	18190741. VBIEscCol77757_0054.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0639.
GeneTree	EBGT00050000010576.
HOGENOM	HBG724457.
OMA	LVFGHWA.
PhylomeDB	Q0TLT8.
ProtClustDB	PRK00166.
Enzyme and pathway databases
BioCyc	ECOL362663:ECP_0051-MONOMER.
Family and domain databases
HAMAP	MF_00199. ApaH. [Tree]
InterPro	IPR004617. ApaH. IPR004843. Metallo_PEstase_dom. [Graphical view]
KO	K01525.
Pfam	PF00149. Metallophos. 1 hit. [Graphical view]
PIRSF	PIRSF000903. B5n-ttraPtase_sm. 1 hit.
TIGRFAMs	TIGR00668. ApaH. 1 hit.
ProtoNet	Search...

Entry information

Entry name

APAH_ECOL5

Accession

Primary (citable) accession number: Q0TLT8

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	September 5, 2006
Last modified:	January 25, 2012
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program