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Protein

Bis(5'-nucleosyl)-tetraphosphatase, symmetrical

Gene

apaH

Organism
Escherichia coli O6:K15:H31 (strain 536 / UPEC)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP.UniRule annotation

Catalytic activityi

P1,P(4)-bis(5'-adenosyl) tetraphosphate + H2O = 2 ADP.UniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciECOL362663:GIY5-50-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Bis(5'-nucleosyl)-tetraphosphatase, symmetricalUniRule annotation (EC:3.6.1.41UniRule annotation)
Alternative name(s):
Ap4A hydrolaseUniRule annotation
Diadenosine 5',5'''-P1,P4-tetraphosphate pyrophosphohydrolaseUniRule annotation
Diadenosine tetraphosphataseUniRule annotation
Gene namesi
Name:apaHUniRule annotation
Ordered Locus Names:ECP_0051
OrganismiEscherichia coli O6:K15:H31 (strain 536 / UPEC)
Taxonomic identifieri362663 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 282282Bis(5'-nucleosyl)-tetraphosphatase, symmetricalPRO_1000012058Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi362663.ECP_0051.

Structurei

3D structure databases

ProteinModelPortaliQ0TLT8.
SMRiQ0TLT8. Positions 2-268.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Ap4A hydrolase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DDT. Bacteria.
COG0639. LUCA.
HOGENOMiHOG000251871.
KOiK01525.
OMAiINAFTRM.

Family and domain databases

Gene3Di3.60.21.10. 2 hits.
HAMAPiMF_00199. ApaH. 1 hit.
InterProiIPR004617. ApaH.
IPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
PIRSFiPIRSF000903. B5n-ttraPtase_sm. 1 hit.
SUPFAMiSSF56300. SSF56300. 1 hit.
TIGRFAMsiTIGR00668. apaH. 1 hit.

Sequencei

Sequence statusi: Complete.

Q0TLT8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATYLIGDVH GCYDELIALL HKVEFTPGKD TLWLTGDLVA RGPGSLDVLR
60 70 80 90 100
YVKSLGDSVR LVLGNHDLHL LAVFAGISRN KPKDRLTPLL EAPDADELLN
110 120 130 140 150
WLRRQPLLQI DEEKKLVMAH AGITPQWDLQ TAKECARDVE AVLSSDSYPF
160 170 180 190 200
FLDAMYGDMP NNWSPELRGL GRLRFITNAF TRMRFCFPNG QLDMYSKESP
210 220 230 240 250
EEAPAPLKPW FAIPGPVAEE YNIAFGHWAS LEGKGTPEGI YALDTGCCWG
260 270 280
GTLTCLRWED KQYFVQPSNR HKDLSEGEAV AS
Length:282
Mass (Da):31,568
Last modified:September 5, 2006 - v1
Checksum:i65075A157B1F9446
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000247 Genomic DNA. Translation: ABG68093.1.
RefSeqiWP_000257181.1. NC_008253.1.

Genome annotation databases

EnsemblBacteriaiABG68093; ABG68093; ECP_0051.
KEGGiecp:ECP_0051.
PATRICi18190741. VBIEscCol77757_0054.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000247 Genomic DNA. Translation: ABG68093.1.
RefSeqiWP_000257181.1. NC_008253.1.

3D structure databases

ProteinModelPortaliQ0TLT8.
SMRiQ0TLT8. Positions 2-268.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi362663.ECP_0051.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABG68093; ABG68093; ECP_0051.
KEGGiecp:ECP_0051.
PATRICi18190741. VBIEscCol77757_0054.

Phylogenomic databases

eggNOGiENOG4105DDT. Bacteria.
COG0639. LUCA.
HOGENOMiHOG000251871.
KOiK01525.
OMAiINAFTRM.

Enzyme and pathway databases

BioCyciECOL362663:GIY5-50-MONOMER.

Family and domain databases

Gene3Di3.60.21.10. 2 hits.
HAMAPiMF_00199. ApaH. 1 hit.
InterProiIPR004617. ApaH.
IPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
PIRSFiPIRSF000903. B5n-ttraPtase_sm. 1 hit.
SUPFAMiSSF56300. SSF56300. 1 hit.
TIGRFAMsiTIGR00668. apaH. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiAPAH_ECOL5
AccessioniPrimary (citable) accession number: Q0TLT8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: September 5, 2006
Last modified: September 7, 2016
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.