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Q0THI2

- Q0THI2_ECOL5

UniProt

Q0THI2 - Q0THI2_ECOL5

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Protein
Superoxide dismutase [Cu-Zn]
Gene
ECP_1592
Organism
Escherichia coli O6:K15:H31 (strain 536 / UPEC)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Destroys radicals which are normally produced within the cells and which are toxic to biological systems By similarity.UniRule annotation

Catalytic activityi

2 superoxide + 2 H+ = O2 + H2O2.UniRule annotation

Cofactori

Binds 1 copper ion per subunit By similarity.UniRule annotation
Binds 1 zinc ion per subunit By similarity.UniRule annotation

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. superoxide dismutase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    OxidoreductaseUniRule annotationImported

    Keywords - Ligandi

    CopperUniRule annotation, Metal-bindingUniRule annotation, ZincUniRule annotation

    Enzyme and pathway databases

    BioCyciECOL362663:GIY5-1599-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Superoxide dismutase [Cu-Zn]UniRule annotation (EC:1.15.1.1UniRule annotation)
    Gene namesi
    Ordered Locus Names:ECP_1592Imported
    OrganismiEscherichia coli O6:K15:H31 (strain 536 / UPEC)Imported
    Taxonomic identifieri362663 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
    ProteomesiUP000009182: Chromosome

    Interactioni

    Protein-protein interaction databases

    STRINGi362663.ECP_1592.

    Structurei

    3D structure databases

    ProteinModelPortaliQ0THI2.
    SMRiQ0THI2. Positions 25-178.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the Cu-Zn superoxide dismutase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2032.
    HOGENOMiHOG000263449.
    KOiK04565.
    OMAiDHPKPLG.
    OrthoDBiEOG6K13RS.

    Family and domain databases

    Gene3Di2.60.40.200. 1 hit.
    InterProiIPR018152. SOD_Cu/Zn_BS.
    IPR001424. SOD_Cu_Zn_dom.
    [Graphical view]
    PfamiPF00080. Sod_Cu. 1 hit.
    [Graphical view]
    SUPFAMiSSF49329. SSF49329. 1 hit.
    PROSITEiPS00332. SOD_CU_ZN_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q0THI2-1 [UniParc]FASTAAdd to Basket

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    MNGGPMKRFS LAILALVVAT GAQAASEKVE MNLVTSQGVG QSIGSVTITE    50
    TDKGLEFSPD LKALPPGEHG FHIHAKGSCQ PATKDGKASA AESAGGHLDP 100
    QNTGKHEGPE GAGHLGDLPA LVVNNDGKAT DAVIAPRLKS LDEVKDKALM 150
    VHVGGDNMSD QPKPLGGGGE RYACGVIK 178
    Length:178
    Mass (Da):18,123
    Last modified:September 5, 2006 - v1
    Checksum:iDC43B99359649615
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000247 Genomic DNA. Translation: ABG69597.1.
    RefSeqiYP_669498.1. NC_008253.1.

    Genome annotation databases

    EnsemblBacteriaiABG69597; ABG69597; ECP_1592.
    GeneIDi4190474.
    KEGGiecp:ECP_1592.
    PATRICi18193908. VBIEscCol77757_1610.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000247 Genomic DNA. Translation: ABG69597.1 .
    RefSeqi YP_669498.1. NC_008253.1.

    3D structure databases

    ProteinModelPortali Q0THI2.
    SMRi Q0THI2. Positions 25-178.
    ModBasei Search...

    Protein-protein interaction databases

    STRINGi 362663.ECP_1592.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABG69597 ; ABG69597 ; ECP_1592 .
    GeneIDi 4190474.
    KEGGi ecp:ECP_1592.
    PATRICi 18193908. VBIEscCol77757_1610.

    Phylogenomic databases

    eggNOGi COG2032.
    HOGENOMi HOG000263449.
    KOi K04565.
    OMAi DHPKPLG.
    OrthoDBi EOG6K13RS.

    Enzyme and pathway databases

    BioCyci ECOL362663:GIY5-1599-MONOMER.

    Family and domain databases

    Gene3Di 2.60.40.200. 1 hit.
    InterProi IPR018152. SOD_Cu/Zn_BS.
    IPR001424. SOD_Cu_Zn_dom.
    [Graphical view ]
    Pfami PF00080. Sod_Cu. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49329. SSF49329. 1 hit.
    PROSITEi PS00332. SOD_CU_ZN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Role of pathogenicity island-associated integrases in the genome plasticity of uropathogenic Escherichia coli strain 536."
      Hochhut B., Wilde C., Balling G., Middendorf B., Dobrindt U., Brzuszkiewicz E., Gottschalk G., Carniel E., Hacker J.
      Mol. Microbiol. 61:584-595(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 536 / UPEC.

    Entry informationi

    Entry nameiQ0THI2_ECOL5
    AccessioniPrimary (citable) accession number: Q0THI2
    Entry historyi
    Integrated into UniProtKB/TrEMBL: September 5, 2006
    Last sequence update: September 5, 2006
    Last modified: July 9, 2014
    This is version 61 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    External Data

    Dasty 3

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