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Protein

Superoxide dismutase [Cu-Zn]

Gene

ECP_1592

Organism
Escherichia coli O6:K15:H31 (strain 536 / UPEC)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Destroys radicals which are normally produced within the cells and which are toxic to biological systems.UniRule annotation

Catalytic activityi

2 superoxide + 2 H+ = O2 + H2O2.UniRule annotation

Cofactori

Protein has several cofactor binding sites:
  • Cu cationUniRule annotationNote: Binds 1 copper ion per subunit.UniRule annotation
  • Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. superoxide dismutase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationImported

Keywords - Ligandi

CopperUniRule annotation, Metal-bindingUniRule annotation, ZincUniRule annotation

Enzyme and pathway databases

BioCyciECOL362663:GIY5-1599-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Superoxide dismutase [Cu-Zn]UniRule annotation (EC:1.15.1.1UniRule annotation)
Gene namesi
Ordered Locus Names:ECP_1592Imported
OrganismiEscherichia coli O6:K15:H31 (strain 536 / UPEC)Imported
Taxonomic identifieri362663 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000009182: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi362663.ECP_1592.

Structurei

3D structure databases

ProteinModelPortaliQ0THI2.
SMRiQ0THI2. Positions 25-178.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Cu-Zn superoxide dismutase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2032.
HOGENOMiHOG000263449.
KOiK04565.
OMAiGARYACG.
OrthoDBiEOG6K13RS.

Family and domain databases

Gene3Di2.60.40.200. 1 hit.
InterProiIPR018152. SOD_Cu/Zn_BS.
IPR001424. SOD_Cu_Zn_dom.
[Graphical view]
PfamiPF00080. Sod_Cu. 1 hit.
[Graphical view]
SUPFAMiSSF49329. SSF49329. 1 hit.
PROSITEiPS00332. SOD_CU_ZN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q0THI2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNGGPMKRFS LAILALVVAT GAQAASEKVE MNLVTSQGVG QSIGSVTITE
60 70 80 90 100
TDKGLEFSPD LKALPPGEHG FHIHAKGSCQ PATKDGKASA AESAGGHLDP
110 120 130 140 150
QNTGKHEGPE GAGHLGDLPA LVVNNDGKAT DAVIAPRLKS LDEVKDKALM
160 170
VHVGGDNMSD QPKPLGGGGE RYACGVIK
Length:178
Mass (Da):18,123
Last modified:September 5, 2006 - v1
Checksum:iDC43B99359649615
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000247 Genomic DNA. Translation: ABG69597.1.
RefSeqiYP_669498.1. NC_008253.1.

Genome annotation databases

EnsemblBacteriaiABG69597; ABG69597; ECP_1592.
GeneIDi4190474.
KEGGiecp:ECP_1592.
PATRICi18193908. VBIEscCol77757_1610.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000247 Genomic DNA. Translation: ABG69597.1.
RefSeqiYP_669498.1. NC_008253.1.

3D structure databases

ProteinModelPortaliQ0THI2.
SMRiQ0THI2. Positions 25-178.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi362663.ECP_1592.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABG69597; ABG69597; ECP_1592.
GeneIDi4190474.
KEGGiecp:ECP_1592.
PATRICi18193908. VBIEscCol77757_1610.

Phylogenomic databases

eggNOGiCOG2032.
HOGENOMiHOG000263449.
KOiK04565.
OMAiGARYACG.
OrthoDBiEOG6K13RS.

Enzyme and pathway databases

BioCyciECOL362663:GIY5-1599-MONOMER.

Family and domain databases

Gene3Di2.60.40.200. 1 hit.
InterProiIPR018152. SOD_Cu/Zn_BS.
IPR001424. SOD_Cu_Zn_dom.
[Graphical view]
PfamiPF00080. Sod_Cu. 1 hit.
[Graphical view]
SUPFAMiSSF49329. SSF49329. 1 hit.
PROSITEiPS00332. SOD_CU_ZN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Role of pathogenicity island-associated integrases in the genome plasticity of uropathogenic Escherichia coli strain 536."
    Hochhut B., Wilde C., Balling G., Middendorf B., Dobrindt U., Brzuszkiewicz E., Gottschalk G., Carniel E., Hacker J.
    Mol. Microbiol. 61:584-595(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 536 / UPECImported.

Entry informationi

Entry nameiQ0THI2_ECOL5
AccessioniPrimary (citable) accession number: Q0THI2
Entry historyi
Integrated into UniProtKB/TrEMBL: September 5, 2006
Last sequence update: September 5, 2006
Last modified: January 7, 2015
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.