Reviewed,
UniProtKB/Swiss-Prot Q0TFZ6 (GATY_ECOL5)
Last modified
June 16, 2009.
Version 19.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
Customize display | text xml rdf/xml gff fasta |
Names and origin
| Protein names | Recommended name: D-tagatose-1,6-bisphosphate aldolase subunit gatY Short name=TagBP aldolase Short name=TBPA EC=4.1.2.40 Alternative name(s): Tagatose-bisphosphate aldolase D-tagatose-bisphosphate aldolase class II | ||||
| Gene names |
| ||||
| Organism | Escherichia coli O6:K15:H31 (strain 536 / UPEC) [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 362663 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia |
Protein attributes
| Sequence length | 284 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | Catalytic subunit of the tagatose-1,6-bisphosphate aldolase gatYZ, which catalyzes the reversible aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to produce tagatose 1,6-bisphosphate (TBP). Requires gatZ subunit for full activity and stability. Is involved in the catabolism of galactitol By similarity. |
| Catalytic activity | D-tagatose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate. HAMAP MF_01294 |
| Cofactor | Binds 1 zinc ion per subunit By similarity. |
| Pathway | Carbohydrate metabolism; D-tagatose 6-phosphate degradation; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-tagatose 6-phosphate: step 2/2. HAMAP MF_01294 |
| Subunit structure | Forms a complex with gatZ By similarity. |
| Sequence similarities | Belongs to the class II fructose-bisphosphate aldolase family. TagBP aldolase gatY subfamily. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Galactitol metabolism |
| Ligand | Metal-binding Zinc |
| Molecular function | Lyase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | galactitol catabolic process Inferred from electronic annotation. Source: HAMAP glycolysisInferred from electronic annotation. Source: InterPro lactose catabolic process via tagatose-6-phosphateInferred from electronic annotation. Source: InterPro |
| Molecular function | fructose-bisphosphate aldolase activity Inferred from electronic annotation. Source: InterPro tagatose-bisphosphate aldolase activityInferred from electronic annotation. Source: HAMAP zinc ion bindingInferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 284 | 284 | D-tagatose-1,6-bisphosphate aldolase subunit gatY HAMAP MF_01294 | PRO_0000355337 | |||||
Regions | |||||||||
| Region | 209 – 211 | 3 | Dihydroxyacetone phosphate binding By similarity | ||||||
| Region | 230 – 233 | 4 | Dihydroxyacetone phosphate binding By similarity | ||||||
Sites | |||||||||
| Active site | 82 | 1 | Proton donor By similarity | ||||||
| Metal binding | 83 | 1 | Zinc; catalytic By similarity | ||||||
| Metal binding | 180 | 1 | Zinc; catalytic By similarity | ||||||
| Metal binding | 208 | 1 | Zinc; catalytic By similarity | ||||||
| Binding site | 181 | 1 | Dihydroxyacetone phosphate; via amide nitrogen By similarity | ||||||
Sequences
| ||||||||||||||||||
References
| [1] | "Role of pathogenicity island-associated integrases in the genome plasticity of uropathogenic Escherichia coli strain 536." Hochhut B., Wilde C., Balling G., Middendorf B., Dobrindt U., Brzuszkiewicz E., Gottschalk G., Carniel E., Hacker J. Mol. Microbiol. 61:584-595(2006) [PubMed: 16879640] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
Cross-references
Sequence databases | |
|---|---|
| CP000247 Genomic DNA. Translation: ABG70133.1. | |
| RefSeq | YP_670034.1. |
3D structure databases | |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 4191685. |
| GenomeReviews | Gene locus ECP_2134 in contig CP000247_GR. |
| KEGG | ecp:ECP_2134. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | Q0TFZ6. |
| OMA | Q0TFZ6. VNEADAF. |
Enzyme and pathway databases | |
| BioCyc | ECOL362663:ECP_2134-MON. |
Family and domain databases | |
| HAMAP | MF_01294. [Tree] |
| InterPro | IPR013785. Aldolase_TIM. IPR000771. Ketose_bisP_aldolase_II. IPR011288. Tag_bisphos_ald. [Graphical view] |
| Gene3D | G3DSA:3.20.20.70. Aldolase_TIM. 1 hit. |
| Pfam | PF01116. F_bP_aldolase. 1 hit. [Graphical view] |
| PIRSF | PIRSF001359. F_bP_aldolase_II. 1 hit. |
| ProDom | PD002376. K_bP_aldolase. 1 hit. [Graphical view] [Entries sharing at least one domain] |
| TIGRFAMs | TIGR00167. cbbA. 1 hit. TIGR01858. tag_bisphos_ald. 1 hit. |
| PROSITE | PS00602. ALDOLASE_CLASS_II_1. 1 hit. PS00806. ALDOLASE_CLASS_II_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | GATY_ECOL5 | ||||||||
| Accession | Primary (citable) accession number: Q0TFZ6 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


