ID   CDD_ECOL5               Reviewed;         294 AA.
AC   Q0TFU8;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 1.
DT   16-JUN-2009, entry version 22.
DE   RecName: Full=Cytidine deaminase;
DE            EC=3.5.4.5;
DE   AltName: Full=Cytidine aminohydrolase;
DE            Short=CDA;
GN   Name=cdd; OrderedLocusNames=ECP_2182;
OS   Escherichia coli O6:K15:H31 (strain 536 / UPEC).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=362663;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16879640; DOI=10.1111/j.1365-2958.2006.05255.x;
RA   Hochhut B., Wilde C., Balling G., Middendorf B., Dobrindt U.,
RA   Brzuszkiewicz E., Gottschalk G., Carniel E., Hacker J.;
RT   "Role of pathogenicity island-associated integrases in the genome
RT   plasticity of uropathogenic Escherichia coli strain 536.";
RL   Mol. Microbiol. 61:584-595(2006).
CC   -!- FUNCTION: This enzyme scavenge exogenous and endogenous cytidine
CC       and 2'-deoxycytidine for UMP synthesis (By similarity).
CC   -!- CATALYTIC ACTIVITY: Cytidine + H(2)O = uridine + NH(3).
CC   -!- COFACTOR: Binds 1 zinc ion (By similarity).
CC   -!- SUBUNIT: Homodimer (By similarity).
CC   -!- SIMILARITY: Belongs to the cytidine and deoxycytidylate deaminase
CC       family.
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DR   EMBL; CP000247; ABG70181.1; -; Genomic_DNA.
DR   RefSeq; YP_670082.1; -.
DR   SMR; Q0TFU8; 1-294.
DR   GeneID; 4189837; -.
DR   GenomeReviews; CP000247_GR; ECP_2182.
DR   KEGG; ecp:ECP_2182; -.
DR   HOGENOM; Q0TFU8; -.
DR   OMA; Q0TFU8; FSPCGHC.
DR   BioCyc; ECOL362663:ECP_2182-MON; -.
DR   GO; GO:0004126; F:cytidine deaminase activity; IEA:HAMAP.
DR   GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0046087; P:cytidine metabolic process; IEA:InterPro.
DR   HAMAP; MF_01558; -; 1.
DR   InterPro; IPR016192; APOBEC/CMP_deaminase_Zn-bd.
DR   InterPro; IPR002125; CMP_dCMP_Zn_bd.
DR   InterPro; IPR006263; Cyt_deam_dimer.
DR   InterPro; IPR013171; dC_C_deam_Zn_bd.
DR   Pfam; PF00383; dCMP_cyt_deam_1; 1.
DR   Pfam; PF08211; dCMP_cyt_deam_2; 1.
DR   TIGRFAMs; TIGR01355; cyt_deam_dimer; 1.
DR   PROSITE; PS00903; CYT_DCMP_DEAMINASES; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Hydrolase; Metal-binding; Zinc.
FT   CHAIN         1    294       Cytidine deaminase.
FT                                /FTId=PRO_1000068951.
FT   REGION       89     91       Substrate binding (By similarity).
FT   ACT_SITE    104    104       Proton donor (By similarity).
FT   METAL       102    102       Zinc; catalytic (By similarity).
FT   METAL       129    129       Zinc; catalytic (By similarity).
FT   METAL       132    132       Zinc; catalytic (By similarity).
SQ   SEQUENCE   294 AA;  31567 MW;  69B5CD68AB145D6C CRC64;
     MHPRFQTAFA QLADNLQSAL EPILADKYFP ALLTGEQVSS LKSATGLDED ALAFALLPLA
     AACARTPLSN FNVGAIARGV SGTWYFGANM EFIGATMQQT VHAEQSAISH AWLSGEKALA
     AITVNYTPCG HCRQFMNELN SGLDLRIHLP GREAHALRDY LPDAFGPKDL EIKTLLMDEQ
     DHGYALTGDA LSQAAIAAAN RSHMPYSKSP SGVALECKDG RIFSGSYAEN AAFNPTLPPL
     QGALILLNLK GYDYPDIQRA VLAEKADAPL IQWDATSATL KALGCHNIDR VLLA
//