Q0TFL0 (UBIG_ECOL5) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 41.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: 3-demethylubiquinone-9 3-methyltransferase EC=2.1.1.64 Alternative name(s): 2-polyprenyl-6-hydroxyphenyl methylase EC=2.1.1.222 3,4-dihydroxy-5-hexaprenylbenzoate methyltransferase Short name=DHHB methyltransferase | ||||
| Gene names |
| ||||
| Organism | Escherichia coli O6:K15:H31 (strain 536 / UPEC) [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 362663 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia |
Protein attributes
| Sequence length | 240 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Function | Non-specific O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway By similarity. |
| Catalytic activity | S-adenosyl-L-methionine + 3-demethylubiquinone-n = S-adenosyl-L-homocysteine + ubiquinone-n. HAMAP MF_00472 S-adenosyl-L-methionine + 3-(all-trans-polyprenyl)benzene-1,2-diol = S-adenosyl-L-homocysteine + 2-methoxy-6-(all-trans-polyprenyl)phenol. |
| Pathway | Cofactor biosynthesis; ubiquinone biosynthesis. HAMAP MF_00472 |
| Sequence similarities | Belongs to the methyltransferase superfamily. UbiG/COQ3 family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Ubiquinone biosynthesis |
| Ligand | S-adenosyl-L-methionine |
| Molecular function | Methyltransferase Transferase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | ubiquinone biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | 2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity Inferred from electronic annotation. Source: InterPro 3-demethylubiquinone-9 3-O-methyltransferase activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||
Molecule processing | |||||||
|---|---|---|---|---|---|---|---|
| Chain | 1 – 240 | 240 | 3-demethylubiquinone-9 3-methyltransferase HAMAP MF_00472 | PRO_1000013899 | |||
Sequences
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References
| [1] | "Role of pathogenicity island-associated integrases in the genome plasticity of uropathogenic Escherichia coli strain 536." Hochhut B., Wilde C., Balling G., Middendorf B., Dobrindt U., Brzuszkiewicz E., Gottschalk G., Carniel E., Hacker J. Mol. Microbiol. 61:584-595(2006) [PubMed: 16879640] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 536 / UPEC. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | CP000247 Genomic DNA. Translation: ABG70269.1. |
| RefSeq | YP_670170.1. NC_008253.1. |
3D structure databases | |
| ProteinModelPortal | Q0TFL0. |
| SMR | Q0TFL0. Positions 46-156. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q0TFL0. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| EnsemblBacteria | EBESCT00000048777; EBESCP00000046966; EBESCG00000047826. |
| GeneID | 4191924. |
| GenomeReviews | Gene locus ECP_2275 in contig CP000247_GR. |
| KEGG | ecp:ECP_2275. |
| NMPDR | fig|340197.3.peg.297. |
| PATRIC | 18195311. VBIEscCol77757_2299. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| eggNOG | COG2227. |
| GeneTree | EBGT00050000009368. |
| HOGENOM | HBG738842. |
| OMA | DHAEIAK. |
| PhylomeDB | Q0TFL0. |
| ProtClustDB | PRK05134. |
Enzyme and pathway databases | |
| BioCyc | ECOL362663:ECP_2275-MONOMER. |
Family and domain databases | |
| HAMAP | MF_00472. UbiG. [Tree] |
| InterPro | IPR013216. Methyltransf_11. IPR010233. UbiG_MeTrfase. [Graphical view] |
| KO | K00568. |
| PANTHER | PTHR23134. PTHR23134. 1 hit. |
| Pfam | PF08241. Methyltransf_11. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR01983. UbiG. 1 hit. |
| ProtoNet | Search... |
Entry information
| Entry name | UBIG_ECOL5 | ||||||||
| Accession | Primary (citable) accession number: Q0TFL0 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Prokaryotic Protein Annotation Program | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

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