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Protein

Anaerobic glycerol-3-phosphate dehydrogenase subunit B

Gene

glpB

Organism
Escherichia coli O6:K15:H31 (strain 536 / UPEC)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor.UniRule annotation

Catalytic activityi

sn-glycerol 3-phosphate + a quinone = glycerone phosphate + a quinol.UniRule annotation

Cofactori

FMNUniRule annotation

Pathway: glycerol degradation via glycerol kinase pathway

This protein is involved in step 1 of the subpathway that synthesizes glycerone phosphate from sn-glycerol 3-phosphate (anaerobic route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Anaerobic glycerol-3-phosphate dehydrogenase subunit B (glpB)
This subpathway is part of the pathway glycerol degradation via glycerol kinase pathway, which is itself part of Polyol metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes glycerone phosphate from sn-glycerol 3-phosphate (anaerobic route), the pathway glycerol degradation via glycerol kinase pathway and in Polyol metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Flavoprotein, FMN

Enzyme and pathway databases

BioCyciECOL362663:GIY5-2296-MONOMER.
UniPathwayiUPA00618; UER00673.

Names & Taxonomyi

Protein namesi
Recommended name:
Anaerobic glycerol-3-phosphate dehydrogenase subunit BUniRule annotation (EC:1.1.5.3UniRule annotation)
Short name:
Anaerobic G-3-P dehydrogenase subunit BUniRule annotation
Short name:
Anaerobic G3Pdhase BUniRule annotation
Gene namesi
Name:glpBUniRule annotation
Ordered Locus Names:ECP_2284
OrganismiEscherichia coli O6:K15:H31 (strain 536 / UPEC)
Taxonomic identifieri362663 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 419419Anaerobic glycerol-3-phosphate dehydrogenase subunit BPRO_0000258901Add
BLAST

Interactioni

Subunit structurei

Composed of a catalytic GlpA/B dimer and of membrane bound GlpC.UniRule annotation

Protein-protein interaction databases

STRINGi362663.ECP_2284.

Structurei

3D structure databases

ProteinModelPortaliQ0TFK1.
SMRiQ0TFK1. Positions 1-60, 257-313, 356-415.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the anaerobic G-3-P dehydrogenase subunit B family.UniRule annotation

Phylogenomic databases

eggNOGiCOG3075.
HOGENOMiHOG000278489.
KOiK00112.
OMAiWYQRDFF.
OrthoDBiEOG6K6V62.

Family and domain databases

HAMAPiMF_00753. Glycerol3P_GlpB.
InterProiIPR003953. FAD_bind_dom.
IPR009158. G3P_DH_GlpB_su.
[Graphical view]
PfamiPF00890. FAD_binding_2. 1 hit.
[Graphical view]
PIRSFiPIRSF000141. Anaerobic_G3P_dh. 1 hit.
TIGRFAMsiTIGR03378. glycerol3P_GlpB. 1 hit.

Sequencei

Sequence statusi: Complete.

Q0TFK1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRFDTVIMGG GLAGLLCGLQ LQKHGLRCAI VTRGQSALHF SSGSLDLLSH
60 70 80 90 100
LPDGQPVTEI HSGLESLRQQ APAHPYTLLG PQRVLDLACQ AQALIAESGA
110 120 130 140 150
QLQGSVELAH QRITPLGTLR STWLSSPEVP VWPLPAKKIC VVGISGLMDF
160 170 180 190 200
QAHLAAASLR ELDLKVETAE IELPELDVLR NNATEFRAVN IARFLDNEEN
210 220 230 240 250
WPLLLDALIP VANTCEMILM PACFGLANDK LWHWLNEKLP CSLMLLPTLP
260 270 280 290 300
PSVLGIRLQN QLQRQFVRQG GVWMPGDEVK KVTCKNGVVN EIWTRNHADI
310 320 330 340 350
PLRPRFAVLA SGSFFSGGLV AERDGIREPI LGLDVLQTAT RGEWYKGDFF
360 370 380 390 400
APQPWQQFGV TTDEALRPSQ AGQTIENLFA IGSVLGGFDP IAQGCGGGVC
410
AVSALHAAQQ IAQRAGGQQ
Length:419
Mass (Da):45,393
Last modified:October 31, 2006 - v2
Checksum:i8CC9C8ADE0ADB2E7
GO

Sequence cautioni

The sequence ABG70278.1 differs from that shown. Reason: Erroneous termination at position 394. Translated as Gly.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000247 Genomic DNA. Translation: ABG70278.1. Sequence problems.
RefSeqiWP_001209947.1. NC_008253.1.
YP_670179.1. NC_008253.1.

Genome annotation databases

EnsemblBacteriaiABG70278; ABG70278; ECP_2284.
KEGGiecp:ECP_2284.
PATRICi18195331. VBIEscCol77757_2309.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000247 Genomic DNA. Translation: ABG70278.1. Sequence problems.
RefSeqiWP_001209947.1. NC_008253.1.
YP_670179.1. NC_008253.1.

3D structure databases

ProteinModelPortaliQ0TFK1.
SMRiQ0TFK1. Positions 1-60, 257-313, 356-415.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi362663.ECP_2284.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABG70278; ABG70278; ECP_2284.
KEGGiecp:ECP_2284.
PATRICi18195331. VBIEscCol77757_2309.

Phylogenomic databases

eggNOGiCOG3075.
HOGENOMiHOG000278489.
KOiK00112.
OMAiWYQRDFF.
OrthoDBiEOG6K6V62.

Enzyme and pathway databases

UniPathwayiUPA00618; UER00673.
BioCyciECOL362663:GIY5-2296-MONOMER.

Family and domain databases

HAMAPiMF_00753. Glycerol3P_GlpB.
InterProiIPR003953. FAD_bind_dom.
IPR009158. G3P_DH_GlpB_su.
[Graphical view]
PfamiPF00890. FAD_binding_2. 1 hit.
[Graphical view]
PIRSFiPIRSF000141. Anaerobic_G3P_dh. 1 hit.
TIGRFAMsiTIGR03378. glycerol3P_GlpB. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Role of pathogenicity island-associated integrases in the genome plasticity of uropathogenic Escherichia coli strain 536."
    Hochhut B., Wilde C., Balling G., Middendorf B., Dobrindt U., Brzuszkiewicz E., Gottschalk G., Carniel E., Hacker J.
    Mol. Microbiol. 61:584-595(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 536 / UPEC.

Entry informationi

Entry nameiGLPB_ECOL5
AccessioniPrimary (citable) accession number: Q0TFK1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: October 31, 2006
Last modified: June 24, 2015
This is version 64 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.