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Q0TF95 (SDHD1_ECOL5) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 36. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
D-serine dehydratase 1
EC=4.3.1.18
Alternative name(s):
D-serine deaminase 1
Short name=DSD 1
Gene names
Name:dsdA1
Ordered Locus Names:ECP_2391
OrganismEscherichia coli O6:K15:H31 (strain 536 / UPEC) [Complete proteome] [HAMAP]
Taxonomic identifier362663 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia

Protein attributes

Sequence length442 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

D-serine = pyruvate + NH3. HAMAP MF_01030

Cofactor

Pyridoxal phosphate By similarity. HAMAP MF_01030

Subunit structure

Monomer By similarity. HAMAP MF_01030

Sequence similarities

Belongs to the serine/threonine dehydratase family. DsdA subfamily.

Ontologies

Keywords
   LigandPyridoxal phosphate
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processD-amino acid metabolic process

Inferred from electronic annotation. Source: InterPro

   Molecular functionD-serine ammonia-lyase activity

Inferred from electronic annotation. Source: EC

pyridoxal phosphate binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 442442D-serine dehydratase 1 HAMAP MF_01030
PRO_0000291729

Amino acid modifications

Modified residue1181N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q0TF95 [UniParc].

Last modified September 5, 2006. Version 1.
Checksum: 91FEEC58F8200BD2

FASTA44247,859
        10         20         30         40         50         60 
MENAKMNSLI AQYPLVKDLV ALQETTWFNP GTTSLAEGLP YVGLTEQDVQ DAHARLSRFA 

        70         80         90        100        110        120 
PYLAKAFPET AATGGIIESE LVAIPAMQKR LEKEYHQPIA GQLLLKKDSH LPISGSIKAR 

       130        140        150        160        170        180 
GGIYEVLAHA EKLALEAGLL TLEDDYSKLL SPEFKQFFSQ YSIAVGSTGN LGLSIGIMSA 

       190        200        210        220        230        240 
RIGFKVTVHM SADARAWKKA KLRSHGVTVV EYEQDYGVAV EEGRKAAQSD PNCFFIDDEN 

       250        260        270        280        290        300 
SRTLFLGYSV AGQRLKAQFA QQGRIVNADN PLFVYLPCGV GGGPGGVAFG LKLAFGDHVH 

       310        320        330        340        350        360 
CFFAEPTHSP CMLLGVHTGL HDQISVQDIG IDNLTAADGL AVGRASGFVG RAMERLLDGF 

       370        380        390        400        410        420 
YTLSDQTMYD MLGWLAQEEG IRLEPSALAG MAGPQRVCAS VSYQQLHGFS AEQLRNATHL 

       430        440 
VWATGGGMVP EEEMNQYLAK GR

« Hide

References

[1]"Role of pathogenicity island-associated integrases in the genome plasticity of uropathogenic Escherichia coli strain 536."
Hochhut B., Wilde C., Balling G., Middendorf B., Dobrindt U., Brzuszkiewicz E., Gottschalk G., Carniel E., Hacker J.
Mol. Microbiol. 61:584-595(2006) [PubMed: 16879640] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 536 / UPEC.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000247 Genomic DNA. Translation: ABG70384.1.
RefSeqYP_670285.1. NC_008253.1.

3D structure databases

ProteinModelPortalQ0TF95.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ0TF95.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBESCT00000048302; EBESCP00000046491; EBESCG00000047352.
GeneID4189628.
GenomeReviewsGene locus ECP_2391 in contig CP000247_GR.
KEGGecp:ECP_2391.
NMPDRfig|340197.3.peg.3902.
PATRIC18195565. VBIEscCol77757_2425.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG3048.
GeneTreeEBGT00050000010604.
HOGENOMHBG288722.
OMATLIGKLW.
PhylomeDBQ0TF95.
ProtClustDBPRK02991.

Enzyme and pathway databases

BioCycECOL362663:ECP_2391-MONOMER.

Family and domain databases

HAMAPMF_01030. D-Ser_dehydrat.
[Tree]
InterProIPR011780. D_Ser_am_lyase.
IPR001926. PyrdxlP-dep_enz_bsu.
IPR000634. Ser/Thr_deHydtase_PyrdxlP-BS.
[Graphical view]
KOK01753.
PANTHERPTHR10314:SF9. D_Ser_am_lyase. 1 hit.
PfamPF00291. PALP. 1 hit.
[Graphical view]
SUPFAMSSF53686. PyrdxlP-dep_enz_bsu. 1 hit.
TIGRFAMsTIGR02035. D_Ser_am_lyase. 1 hit.
PROSITEPS00165. DEHYDRATASE_SER_THR. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSDHD1_ECOL5
AccessionPrimary (citable) accession number: Q0TF95
Entry history
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: September 5, 2006
Last modified: January 25, 2012
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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