Reviewed, UniProtKB/Swiss-Prot Q0TF95 (SDHD1_ECOL5)

Names and origin

Protein names

Recommended name:
    D-serine dehydratase 1
    EC=4.3.1.18
Alternative name(s):
    D-serine deaminase 1
      Short name=DSD 1

Gene names

Name:	dsdA1
Ordered Locus Names:	ECP_2391

Organism

Escherichia coli O6:K15:H31 (strain 536 / UPEC) [Complete proteome] [HAMAP]

Taxonomic identifier

362663 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia

Protein attributes

Sequence length	442 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	D-serine = pyruvate + NH3. HAMAP MF_01030
Cofactor	Pyridoxal phosphate By similarity.
Subunit structure	Monomer By similarity.
Sequence similarities	Belongs to the serine/threonine dehydratase family. DsdA subfamily.

Ontologies

Keywords
Ligand	Pyridoxal phosphate
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	D-amino acid metabolic process Inferred from electronic annotation. Source: HAMAP
Molecular function	D-serine ammonia-lyase activity Inferred from electronic annotation. Source: EC hydro-lyase activity Inferred from electronic annotation. Source: HAMAP pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 442	442	D-serine dehydratase 1 HAMAP MF_01030		PRO_0000291729
Amino acid modifications
	Modified residue	118	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q0TF95-1 [UniParc]. Last modified September 5, 2006. Version 1. Checksum: 91FEEC58F8200BD2	FASTA	442	47,859
	10 20 30 40 50 60 MENAKMNSLI AQYPLVKDLV ALQETTWFNP GTTSLAEGLP YVGLTEQDVQ DAHARLSRFA 70 80 90 100 110 120 PYLAKAFPET AATGGIIESE LVAIPAMQKR LEKEYHQPIA GQLLLKKDSH LPISGSIKAR 130 140 150 160 170 180 GGIYEVLAHA EKLALEAGLL TLEDDYSKLL SPEFKQFFSQ YSIAVGSTGN LGLSIGIMSA 190 200 210 220 230 240 RIGFKVTVHM SADARAWKKA KLRSHGVTVV EYEQDYGVAV EEGRKAAQSD PNCFFIDDEN 250 260 270 280 290 300 SRTLFLGYSV AGQRLKAQFA QQGRIVNADN PLFVYLPCGV GGGPGGVAFG LKLAFGDHVH 310 320 330 340 350 360 CFFAEPTHSP CMLLGVHTGL HDQISVQDIG IDNLTAADGL AVGRASGFVG RAMERLLDGF 370 380 390 400 410 420 YTLSDQTMYD MLGWLAQEEG IRLEPSALAG MAGPQRVCAS VSYQQLHGFS AEQLRNATHL 430 440 VWATGGGMVP EEEMNQYLAK GR

References

[1]

"Role of pathogenicity island-associated integrases in the genome plasticity of uropathogenic Escherichia coli strain 536." Hochhut B., Wilde C., Balling G., Middendorf B., Dobrindt U., Brzuszkiewicz E., Gottschalk G., Carniel E., Hacker J. Mol. Microbiol. 61:584-595(2006) [PubMed: 16879640] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000247 Genomic DNA. Translation: ABG70384.1.
RefSeq	YP_670285.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	4189628.
GenomeReviews	Gene locus ECP_2391 in contig CP000247_GR.
KEGG	ecp:ECP_2391.
NMPDR	fig|340197.3.peg.3902.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q0TF95.
OMA	Q0TF95. QLHGFSA.
Enzyme and pathway databases
BioCyc	ECOL362663:ECP_2391-MON.
Family and domain databases
HAMAP	MF_01030. [Tree]
InterPro	IPR011780. D_Ser_am_lyase. IPR001926. PyrdxlP-dep_enz_bsu. IPR000634. Ser/Thr_deHydtase_PyrdxlP-BS. [Graphical view]
PANTHER	PTHR10314:SF9. D_Ser_am_lyase. 1 hit.
Pfam	PF00291. PALP. 1 hit. [Graphical view]
TIGRFAMs	TIGR02035. D_Ser_am_lyase. 1 hit.
PROSITE	PS00165. DEHYDRATASE_SER_THR. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SDHD1_ECOL5

Accession

Primary (citable) accession number: Q0TF95

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 26, 2007
Last sequence update:	September 5, 2006
Last modified:	June 16, 2009
This is version 21 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)