Q0TDY9 (KDUI_ECOL5) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase
EC=5.3.1.17

Alternative name(s):
5-keto-4-deoxyuronate isomerase
DKI isomerase

Gene names

Name:	kduI
Ordered Locus Names:	ECP_2856

Organism

Escherichia coli O6:K15:H31 (strain 536 / UPEC) [Complete proteome] [HAMAP]

Taxonomic identifier

362663 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia

Protein attributes

Sequence length	278 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	4-deoxy-L-threo-5-hexosulose uronate = 3-deoxy-D-glycero-2,5-hexodiulosonate. HAMAP MF_00687
Pathway	Glycan metabolism; pectin degradation; 2-dehydro-3-deoxy-D-gluconate from pectin: step 4/5. HAMAP MF_00687
Subunit structure	Homohexamer By similarity. HAMAP MF_00687
Sequence similarities	Belongs to the kduI family.

Ontologies

Keywords
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	pectin catabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 278	278	4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase HAMAP MF_00687		PRO_1000045082

Sequences

	Sequence		Length	Mass (Da)
	Q0TDY9 [UniParc]. Last modified September 5, 2006. Version 1. Checksum: 7AF3DD98DE74D597	FASTA	278	31,076
	10 20 30 40 50 60 MDVRQSIHSA HAKTLDTQGL RNEFLVEKVF VADEYTMVYS HIDRIIVGGI MPVTKTVSVG 70 80 90 100 110 120 GEVGKQLGVS YFLERRELGV INIGGAGTIT VDGQCYEIGH RDALYVGKGA KEVVFASIDT 130 140 150 160 170 180 ATPAKFYYNC APAHTTYPTK KVTPDEVSPV TLGDNLTSNR RTINKYFVPD VLETCQLSMG 190 200 210 220 230 240 LTELAPGNLW NTMPCHTHER RMEVYFYFNM DDDACVFHMM GQPQETRHIV MHNEQAVISP 250 260 270 SWSIHSGVGT KAYTFIWGMV GENQVFDDMD HVAVKDLR

References

[1]

"Role of pathogenicity island-associated integrases in the genome plasticity of uropathogenic Escherichia coli strain 536." Hochhut B., Wilde C., Balling G., Middendorf B., Dobrindt U., Brzuszkiewicz E., Gottschalk G., Carniel E., Hacker J. Mol. Microbiol. 61:584-595(2006) [PubMed: 16879640] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 536 / UPEC.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000247 Genomic DNA. Translation: ABG70840.1.
RefSeq	YP_670741.1. NC_008253.1.
3D structure databases
ProteinModelPortal	Q0TDY9.
SMR	Q0TDY9. Positions 1-277.
ModBase	Search...
Protein-protein interaction databases
STRING	Q0TDY9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBESCT00000049231; EBESCP00000047420; EBESCG00000048279.
GeneID	4188108.
GenomeReviews	Gene locus ECP_2856 in contig CP000247_GR.
KEGG	ecp:ECP_2856.
PATRIC	18196542. VBIEscCol77757_2894.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG3717.
GeneTree	EBGT00050000011662.
HOGENOM	HBG301328.
OMA	AKFYLVS.
PhylomeDB	Q0TDY9.
ProtClustDB	PRK00924.
Enzyme and pathway databases
BioCyc	ECOL362663:ECP_2856-MONOMER.
Family and domain databases
HAMAP	MF_00687. KduI. [Tree]
InterPro	IPR011051. Cupin_RmlC_type. IPR007045. KduI. IPR021120. KduI/IolB_isomerase. [Graphical view]
KO	K01815.
Pfam	PF04962. KduI. 1 hit. [Graphical view]
PIRSF	PIRSF006625. KduI. 1 hit.
SUPFAM	SSF51182. RmlC_like_cupin. 1 hit.
ProtoNet	Search...

Entry information

Entry name

KDUI_ECOL5

Accession

Primary (citable) accession number: Q0TDY9

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	September 5, 2006
Last modified:	January 25, 2012
This is version 38 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program