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Q0TDY9

- KDUI_ECOL5

UniProt

Q0TDY9 - KDUI_ECOL5

Protein

4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase

Gene

kduI

Organism
Escherichia coli O6:K15:H31 (strain 536 / UPEC)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 57 (01 Oct 2014)
      Sequence version 1 (05 Sep 2006)
      Previous versions | rss
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    Functioni

    Catalyzes the isomerization of 5-dehydro-4-deoxy-D-glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate.UniRule annotation

    Catalytic activityi

    5-dehydro-4-deoxy-D-glucuronate = 3-deoxy-D-glycero-2,5-hexodiulosonate.UniRule annotation

    Cofactori

    Binds 1 zinc ion per subunit.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi196 – 1961ZincUniRule annotation
    Metal bindingi198 – 1981ZincUniRule annotation
    Metal bindingi203 – 2031ZincUniRule annotation
    Metal bindingi245 – 2451ZincUniRule annotation

    GO - Molecular functioni

    1. 4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase activity Source: UniProtKB-HAMAP
    2. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. pectin catabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Isomerase

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    BioCyciECOL362663:GIY5-2877-MONOMER.
    UniPathwayiUPA00545; UER00826.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    4-deoxy-L-threo-5-hexosulose-uronate ketol-isomeraseUniRule annotation (EC:5.3.1.17UniRule annotation)
    Alternative name(s):
    5-keto-4-deoxyuronate isomeraseUniRule annotation
    DKI isomeraseUniRule annotation
    Gene namesi
    Name:kduIUniRule annotation
    Ordered Locus Names:ECP_2856
    OrganismiEscherichia coli O6:K15:H31 (strain 536 / UPEC)
    Taxonomic identifieri362663 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
    ProteomesiUP000009182: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 2782784-deoxy-L-threo-5-hexosulose-uronate ketol-isomerasePRO_1000045082Add
    BLAST

    Interactioni

    Subunit structurei

    Homohexamer.UniRule annotation

    Protein-protein interaction databases

    STRINGi362663.ECP_2856.

    Structurei

    3D structure databases

    ProteinModelPortaliQ0TDY9.
    SMRiQ0TDY9. Positions 1-277.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the KduI family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG3717.
    HOGENOMiHOG000124379.
    KOiK01815.
    OMAiEIGHREA.
    OrthoDBiEOG664CJZ.

    Family and domain databases

    Gene3Di2.60.120.500. 1 hit.
    2.60.120.520. 1 hit.
    HAMAPiMF_00687. KduI.
    InterProiIPR007045. KduI.
    IPR021120. KduI/IolB_isomerase.
    IPR027447. KduI_C.
    IPR027449. KduI_N.
    IPR011051. RmlC_Cupin.
    [Graphical view]
    PfamiPF04962. KduI. 1 hit.
    [Graphical view]
    PIRSFiPIRSF006625. KduI. 1 hit.
    SUPFAMiSSF51182. SSF51182. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q0TDY9-1 [UniParc]FASTAAdd to Basket

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    MDVRQSIHSA HAKTLDTQGL RNEFLVEKVF VADEYTMVYS HIDRIIVGGI    50
    MPVTKTVSVG GEVGKQLGVS YFLERRELGV INIGGAGTIT VDGQCYEIGH 100
    RDALYVGKGA KEVVFASIDT ATPAKFYYNC APAHTTYPTK KVTPDEVSPV 150
    TLGDNLTSNR RTINKYFVPD VLETCQLSMG LTELAPGNLW NTMPCHTHER 200
    RMEVYFYFNM DDDACVFHMM GQPQETRHIV MHNEQAVISP SWSIHSGVGT 250
    KAYTFIWGMV GENQVFDDMD HVAVKDLR 278
    Length:278
    Mass (Da):31,076
    Last modified:September 5, 2006 - v1
    Checksum:i7AF3DD98DE74D597
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000247 Genomic DNA. Translation: ABG70840.1.
    RefSeqiYP_670741.1. NC_008253.1.

    Genome annotation databases

    EnsemblBacteriaiABG70840; ABG70840; ECP_2856.
    GeneIDi4188108.
    KEGGiecp:ECP_2856.
    PATRICi18196542. VBIEscCol77757_2894.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000247 Genomic DNA. Translation: ABG70840.1 .
    RefSeqi YP_670741.1. NC_008253.1.

    3D structure databases

    ProteinModelPortali Q0TDY9.
    SMRi Q0TDY9. Positions 1-277.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 362663.ECP_2856.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABG70840 ; ABG70840 ; ECP_2856 .
    GeneIDi 4188108.
    KEGGi ecp:ECP_2856.
    PATRICi 18196542. VBIEscCol77757_2894.

    Phylogenomic databases

    eggNOGi COG3717.
    HOGENOMi HOG000124379.
    KOi K01815.
    OMAi EIGHREA.
    OrthoDBi EOG664CJZ.

    Enzyme and pathway databases

    UniPathwayi UPA00545 ; UER00826 .
    BioCyci ECOL362663:GIY5-2877-MONOMER.

    Family and domain databases

    Gene3Di 2.60.120.500. 1 hit.
    2.60.120.520. 1 hit.
    HAMAPi MF_00687. KduI.
    InterProi IPR007045. KduI.
    IPR021120. KduI/IolB_isomerase.
    IPR027447. KduI_C.
    IPR027449. KduI_N.
    IPR011051. RmlC_Cupin.
    [Graphical view ]
    Pfami PF04962. KduI. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF006625. KduI. 1 hit.
    SUPFAMi SSF51182. SSF51182. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Role of pathogenicity island-associated integrases in the genome plasticity of uropathogenic Escherichia coli strain 536."
      Hochhut B., Wilde C., Balling G., Middendorf B., Dobrindt U., Brzuszkiewicz E., Gottschalk G., Carniel E., Hacker J.
      Mol. Microbiol. 61:584-595(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 536 / UPEC.

    Entry informationi

    Entry nameiKDUI_ECOL5
    AccessioniPrimary (citable) accession number: Q0TDY9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: September 5, 2006
    Last modified: October 1, 2014
    This is version 57 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3