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Protein

4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase

Gene

kduI

Organism
Escherichia coli O6:K15:H31 (strain 536 / UPEC)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the isomerization of 5-dehydro-4-deoxy-D-glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate.UniRule annotation

Catalytic activityi

5-dehydro-4-deoxy-D-glucuronate = 3-deoxy-D-glycero-2,5-hexodiulosonate.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Pathway:ipectin degradation

This protein is involved in step 4 of the subpathway that synthesizes 2-dehydro-3-deoxy-D-gluconate from pectin.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. no protein annotated in this organism
  3. no protein annotated in this organism
  4. 4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase (kduI)
  5. no protein annotated in this organism
This subpathway is part of the pathway pectin degradation, which is itself part of Glycan metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 2-dehydro-3-deoxy-D-gluconate from pectin, the pathway pectin degradation and in Glycan metabolism.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi196 – 1961ZincUniRule annotation
Metal bindingi198 – 1981ZincUniRule annotation
Metal bindingi203 – 2031ZincUniRule annotation
Metal bindingi245 – 2451ZincUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciECOL362663:GIY5-2877-MONOMER.
UniPathwayiUPA00545; UER00826.

Names & Taxonomyi

Protein namesi
Recommended name:
4-deoxy-L-threo-5-hexosulose-uronate ketol-isomeraseUniRule annotation (EC:5.3.1.17UniRule annotation)
Alternative name(s):
5-keto-4-deoxyuronate isomeraseUniRule annotation
DKI isomeraseUniRule annotation
Gene namesi
Name:kduIUniRule annotation
Ordered Locus Names:ECP_2856
OrganismiEscherichia coli O6:K15:H31 (strain 536 / UPEC)
Taxonomic identifieri362663 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 2782784-deoxy-L-threo-5-hexosulose-uronate ketol-isomerasePRO_1000045082Add
BLAST

Interactioni

Subunit structurei

Homohexamer.UniRule annotation

Protein-protein interaction databases

STRINGi362663.ECP_2856.

Structurei

3D structure databases

ProteinModelPortaliQ0TDY9.
SMRiQ0TDY9. Positions 1-277.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the KduI family.UniRule annotation

Phylogenomic databases

eggNOGiCOG3717.
HOGENOMiHOG000124379.
KOiK01815.
OMAiIWAMAGE.
OrthoDBiEOG664CJZ.

Family and domain databases

Gene3Di2.60.120.500. 1 hit.
2.60.120.520. 1 hit.
HAMAPiMF_00687. KduI.
InterProiIPR007045. KduI.
IPR021120. KduI/IolB_isomerase.
IPR027447. KduI_C.
IPR027449. KduI_N.
IPR011051. RmlC_Cupin.
[Graphical view]
PfamiPF04962. KduI. 1 hit.
[Graphical view]
PIRSFiPIRSF006625. KduI. 1 hit.
SUPFAMiSSF51182. SSF51182. 1 hit.

Sequencei

Sequence statusi: Complete.

Q0TDY9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDVRQSIHSA HAKTLDTQGL RNEFLVEKVF VADEYTMVYS HIDRIIVGGI
60 70 80 90 100
MPVTKTVSVG GEVGKQLGVS YFLERRELGV INIGGAGTIT VDGQCYEIGH
110 120 130 140 150
RDALYVGKGA KEVVFASIDT ATPAKFYYNC APAHTTYPTK KVTPDEVSPV
160 170 180 190 200
TLGDNLTSNR RTINKYFVPD VLETCQLSMG LTELAPGNLW NTMPCHTHER
210 220 230 240 250
RMEVYFYFNM DDDACVFHMM GQPQETRHIV MHNEQAVISP SWSIHSGVGT
260 270
KAYTFIWGMV GENQVFDDMD HVAVKDLR
Length:278
Mass (Da):31,076
Last modified:September 5, 2006 - v1
Checksum:i7AF3DD98DE74D597
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000247 Genomic DNA. Translation: ABG70840.1.
RefSeqiWP_000383248.1. NC_008253.1.

Genome annotation databases

EnsemblBacteriaiABG70840; ABG70840; ECP_2856.
KEGGiecp:ECP_2856.
PATRICi18196542. VBIEscCol77757_2894.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000247 Genomic DNA. Translation: ABG70840.1.
RefSeqiWP_000383248.1. NC_008253.1.

3D structure databases

ProteinModelPortaliQ0TDY9.
SMRiQ0TDY9. Positions 1-277.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi362663.ECP_2856.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABG70840; ABG70840; ECP_2856.
KEGGiecp:ECP_2856.
PATRICi18196542. VBIEscCol77757_2894.

Phylogenomic databases

eggNOGiCOG3717.
HOGENOMiHOG000124379.
KOiK01815.
OMAiIWAMAGE.
OrthoDBiEOG664CJZ.

Enzyme and pathway databases

UniPathwayiUPA00545; UER00826.
BioCyciECOL362663:GIY5-2877-MONOMER.

Family and domain databases

Gene3Di2.60.120.500. 1 hit.
2.60.120.520. 1 hit.
HAMAPiMF_00687. KduI.
InterProiIPR007045. KduI.
IPR021120. KduI/IolB_isomerase.
IPR027447. KduI_C.
IPR027449. KduI_N.
IPR011051. RmlC_Cupin.
[Graphical view]
PfamiPF04962. KduI. 1 hit.
[Graphical view]
PIRSFiPIRSF006625. KduI. 1 hit.
SUPFAMiSSF51182. SSF51182. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Role of pathogenicity island-associated integrases in the genome plasticity of uropathogenic Escherichia coli strain 536."
    Hochhut B., Wilde C., Balling G., Middendorf B., Dobrindt U., Brzuszkiewicz E., Gottschalk G., Carniel E., Hacker J.
    Mol. Microbiol. 61:584-595(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 536 / UPEC.

Entry informationi

Entry nameiKDUI_ECOL5
AccessioniPrimary (citable) accession number: Q0TDY9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: September 5, 2006
Last modified: July 22, 2015
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.