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Q0TDY9

- KDUI_ECOL5

UniProt

Q0TDY9 - KDUI_ECOL5

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Protein
4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase
Gene
kduI, ECP_2856
Organism
Escherichia coli O6:K15:H31 (strain 536 / UPEC)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the isomerization of 5-dehydro-4-deoxy-D-glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate By similarity.UniRule annotation

Catalytic activityi

5-dehydro-4-deoxy-D-glucuronate = 3-deoxy-D-glycero-2,5-hexodiulosonate.UniRule annotation

Cofactori

Binds 1 zinc ion per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi196 – 1961Zinc By similarity
Metal bindingi198 – 1981Zinc By similarity
Metal bindingi203 – 2031Zinc By similarity
Metal bindingi245 – 2451Zinc By similarity

GO - Molecular functioni

  1. 4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase activity Source: UniProtKB-HAMAP
  2. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. pectin catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciECOL362663:GIY5-2877-MONOMER.
UniPathwayiUPA00545; UER00826.

Names & Taxonomyi

Protein namesi
Recommended name:
4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase (EC:5.3.1.17)
Alternative name(s):
5-keto-4-deoxyuronate isomerase
DKI isomerase
Gene namesi
Name:kduI
Ordered Locus Names:ECP_2856
OrganismiEscherichia coli O6:K15:H31 (strain 536 / UPEC)
Taxonomic identifieri362663 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000009182: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 2782784-deoxy-L-threo-5-hexosulose-uronate ketol-isomeraseUniRule annotation
PRO_1000045082Add
BLAST

Interactioni

Subunit structurei

Homohexamer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi362663.ECP_2856.

Structurei

3D structure databases

ProteinModelPortaliQ0TDY9.
SMRiQ0TDY9. Positions 1-277.

Family & Domainsi

Sequence similaritiesi

Belongs to the KduI family.

Phylogenomic databases

eggNOGiCOG3717.
HOGENOMiHOG000124379.
KOiK01815.
OMAiEIGHREA.
OrthoDBiEOG664CJZ.

Family and domain databases

Gene3Di2.60.120.500. 1 hit.
2.60.120.520. 1 hit.
HAMAPiMF_00687. KduI.
InterProiIPR007045. KduI.
IPR021120. KduI/IolB_isomerase.
IPR027447. KduI_C.
IPR027449. KduI_N.
IPR011051. RmlC_Cupin.
[Graphical view]
PfamiPF04962. KduI. 1 hit.
[Graphical view]
PIRSFiPIRSF006625. KduI. 1 hit.
SUPFAMiSSF51182. SSF51182. 1 hit.

Sequencei

Sequence statusi: Complete.

Q0TDY9-1 [UniParc]FASTAAdd to Basket

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MDVRQSIHSA HAKTLDTQGL RNEFLVEKVF VADEYTMVYS HIDRIIVGGI    50
MPVTKTVSVG GEVGKQLGVS YFLERRELGV INIGGAGTIT VDGQCYEIGH 100
RDALYVGKGA KEVVFASIDT ATPAKFYYNC APAHTTYPTK KVTPDEVSPV 150
TLGDNLTSNR RTINKYFVPD VLETCQLSMG LTELAPGNLW NTMPCHTHER 200
RMEVYFYFNM DDDACVFHMM GQPQETRHIV MHNEQAVISP SWSIHSGVGT 250
KAYTFIWGMV GENQVFDDMD HVAVKDLR 278
Length:278
Mass (Da):31,076
Last modified:September 5, 2006 - v1
Checksum:i7AF3DD98DE74D597
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000247 Genomic DNA. Translation: ABG70840.1.
RefSeqiYP_670741.1. NC_008253.1.

Genome annotation databases

EnsemblBacteriaiABG70840; ABG70840; ECP_2856.
GeneIDi4188108.
KEGGiecp:ECP_2856.
PATRICi18196542. VBIEscCol77757_2894.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000247 Genomic DNA. Translation: ABG70840.1 .
RefSeqi YP_670741.1. NC_008253.1.

3D structure databases

ProteinModelPortali Q0TDY9.
SMRi Q0TDY9. Positions 1-277.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 362663.ECP_2856.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABG70840 ; ABG70840 ; ECP_2856 .
GeneIDi 4188108.
KEGGi ecp:ECP_2856.
PATRICi 18196542. VBIEscCol77757_2894.

Phylogenomic databases

eggNOGi COG3717.
HOGENOMi HOG000124379.
KOi K01815.
OMAi EIGHREA.
OrthoDBi EOG664CJZ.

Enzyme and pathway databases

UniPathwayi UPA00545 ; UER00826 .
BioCyci ECOL362663:GIY5-2877-MONOMER.

Family and domain databases

Gene3Di 2.60.120.500. 1 hit.
2.60.120.520. 1 hit.
HAMAPi MF_00687. KduI.
InterProi IPR007045. KduI.
IPR021120. KduI/IolB_isomerase.
IPR027447. KduI_C.
IPR027449. KduI_N.
IPR011051. RmlC_Cupin.
[Graphical view ]
Pfami PF04962. KduI. 1 hit.
[Graphical view ]
PIRSFi PIRSF006625. KduI. 1 hit.
SUPFAMi SSF51182. SSF51182. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Role of pathogenicity island-associated integrases in the genome plasticity of uropathogenic Escherichia coli strain 536."
    Hochhut B., Wilde C., Balling G., Middendorf B., Dobrindt U., Brzuszkiewicz E., Gottschalk G., Carniel E., Hacker J.
    Mol. Microbiol. 61:584-595(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 536 / UPEC.

Entry informationi

Entry nameiKDUI_ECOL5
AccessioniPrimary (citable) accession number: Q0TDY9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: September 5, 2006
Last modified: July 9, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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