Q0TDY9 (KDUI_ECOL5) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase
EC=5.3.1.17

Alternative name(s):
5-keto-4-deoxyuronate isomerase
DKI isomerase

Gene names

Name:	kduI
Ordered Locus Names:	ECP_2856

Organism

Escherichia coli O6:K15:H31 (strain 536 / UPEC) [Complete proteome] [HAMAP]

Taxonomic identifier

362663 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia › Escherichia coli

Protein attributes

Sequence length	278 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the isomerization of 5-dehydro-4-deoxy-D-glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate By similarity. HAMAP-Rule MF_00687
Catalytic activity	5-dehydro-4-deoxy-D-glucuronate = 3-deoxy-D-glycero-2,5-hexodiulosonate. HAMAP-Rule MF_00687
Cofactor	Binds 1 zinc ion per subunit By similarity.
Pathway	Glycan metabolism; pectin degradation; 2-dehydro-3-deoxy-D-gluconate from pectin: step 4/5. HAMAP-Rule MF_00687
Subunit structure	Homohexamer By similarity.
Sequence similarities	Belongs to the KduI family.

Ontologies

Keywords
Ligand	Metal-binding Zinc
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	pectin catabolic process Inferred from electronic annotation. Source: HAMAP
Molecular_function	4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase activity Inferred from electronic annotation. Source: HAMAP zinc ion binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 278	278	4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase HAMAP-Rule MF_00687		PRO_1000045082
Sites
	Metal binding	196	1	Zinc By similarity
	Metal binding	198	1	Zinc By similarity
	Metal binding	203	1	Zinc By similarity
	Metal binding	245	1	Zinc By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q0TDY9 [UniParc]. Last modified September 5, 2006. Version 1. Checksum: 7AF3DD98DE74D597	FASTA	278	31,076
	10 20 30 40 50 60 MDVRQSIHSA HAKTLDTQGL RNEFLVEKVF VADEYTMVYS HIDRIIVGGI MPVTKTVSVG 70 80 90 100 110 120 GEVGKQLGVS YFLERRELGV INIGGAGTIT VDGQCYEIGH RDALYVGKGA KEVVFASIDT 130 140 150 160 170 180 ATPAKFYYNC APAHTTYPTK KVTPDEVSPV TLGDNLTSNR RTINKYFVPD VLETCQLSMG 190 200 210 220 230 240 LTELAPGNLW NTMPCHTHER RMEVYFYFNM DDDACVFHMM GQPQETRHIV MHNEQAVISP 250 260 270 SWSIHSGVGT KAYTFIWGMV GENQVFDDMD HVAVKDLR

References

[1]

"Role of pathogenicity island-associated integrases in the genome plasticity of uropathogenic Escherichia coli strain 536." Hochhut B., Wilde C., Balling G., Middendorf B., Dobrindt U., Brzuszkiewicz E., Gottschalk G., Carniel E., Hacker J. Mol. Microbiol. 61:584-595(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 536 / UPEC.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000247 Genomic DNA. Translation: ABG70840.1.
RefSeq	YP_670741.1. NC_008253.1.
3D structure databases
ProteinModelPortal	Q0TDY9.
SMR	Q0TDY9. Positions 1-277.
ModBase	Search...
Protein-protein interaction databases
STRING	362663.ECP_2856.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABG70840; ABG70840; ECP_2856.
GeneID	4188108.
KEGG	ecp:ECP_2856.
PATRIC	18196542. VBIEscCol77757_2894.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG3717.
HOGENOM	HOG000124379.
KO	K01815.
OMA	AGENYTF.
PhylomeDB	Q0TDY9.
ProtClustDB	PRK00924.
Enzyme and pathway databases
BioCyc	ECOL362663:GIY5-2877-MONOMER.
UniPathway	UPA00545; UER00826.
Family and domain databases
HAMAP	MF_00687. KduI.
InterPro	IPR007045. KduI. IPR021120. KduI/IolB_isomerase. IPR011051. RmlC_Cupin. [Graphical view]
Pfam	PF04962. KduI. 1 hit. [Graphical view]
PIRSF	PIRSF006625. KduI. 1 hit.
SUPFAM	SSF51182. RmlC_like_cupin. 1 hit.
ProtoNet	Search...

Entry information

Entry name

KDUI_ECOL5

Accession

Primary (citable) accession number: Q0TDY9

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	September 5, 2006
Last modified:	May 1, 2013
This is version 50 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program