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Q0TD22

- RLMG_ECOL5

UniProt

Q0TD22 - RLMG_ECOL5

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Protein
Ribosomal RNA large subunit methyltransferase G
Gene
rlmG, ECP_3175
Organism
Escherichia coli O6:K15:H31 (strain 536 / UPEC)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Specifically methylates the guanine in position 1835 (m2G1835) of 23S rRNA By similarity.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(1835) in 23S rRNA = S-adenosyl-L-homocysteine + N(2)-methylguanine(1835) in 23S rRNA.UniRule annotation

GO - Molecular functioni

  1. 23S rRNA (guanine(1835)-N(2))-methyltransferase activity Source: UniProtKB-EC
  2. nucleic acid binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

rRNA processing

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciECOL362663:GIY5-3197-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribosomal RNA large subunit methyltransferase G (EC:2.1.1.174)
Alternative name(s):
23S rRNA m2G1835 methyltransferase
rRNA (guanine-N(2)-)-methyltransferase RlmG
Gene namesi
Name:rlmG
Ordered Locus Names:ECP_3175
OrganismiEscherichia coli O6:K15:H31 (strain 536 / UPEC)
Taxonomic identifieri362663 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000009182: Chromosome

Subcellular locationi

Cytoplasm Reviewed prediction UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 378378Ribosomal RNA large subunit methyltransferase GUniRule annotation
PRO_0000366464Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi362663.ECP_3175.

Structurei

3D structure databases

ProteinModelPortaliQ0TD22.
SMRiQ0TD22. Positions 27-372.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2813.
HOGENOMiHOG000246323.
KOiK11391.
OMAiDIGARIM.
OrthoDBiEOG67X1ZC.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_01859. 23SrRNA_methyltr_G.
InterProiIPR002052. DNA_methylase_N6_adenine_CS.
IPR017237. rRNA_m2G-MeTrfase_RsmD.
IPR029063. SAM-dependent_MTases-like.
IPR007848. Small_mtfrase_dom.
[Graphical view]
PfamiPF05175. MTS. 1 hit.
[Graphical view]
PIRSFiPIRSF037565. RRNA_m2G_Mtase_RsmD_prd. 1 hit.
SUPFAMiSSF53335. SSF53335. 1 hit.

Sequencei

Sequence statusi: Complete.

Q0TD22-1 [UniParc]FASTAAdd to Basket

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MSHLDNGFRS LTLQRFPATD DVNPLQAWEA ADEYLLQQLD DTEIRGPVLI    50
LNDAFGALSC ALAEHKPYSI GDSYISELAT RENLRLNGID ESSVKFLDST 100
ADYPQQPGVV LIKVPKTLAL LEQQLRALRK VVTPDTRIIA GAKARDIHTS 150
TLELFEKVLG PTTTTLAWKK ARLINCTFNE PPLVDAPQTV SWKLEGTDWT 200
IHNHANVFSR TGLDIGARFF MQHLPENLEG EIVDLGCGNG VIGLTLLDKN 250
PQAKVVFVDE SPMAVASSRL NVETNMPEAL DRCEFMINNA LSGVEPFRFN 300
AVLCNPPFHQ QHALTDNVAW EMFHHARRCL KINGELYIVA NRHLDYFHKL 350
KKIFGNCTTI ATNNKFVVLK AVKLGRRR 378
Length:378
Mass (Da):42,339
Last modified:September 5, 2006 - v1
Checksum:i15BB5B3E8B8BE9CE
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000247 Genomic DNA. Translation: ABG71157.1.
RefSeqiYP_671058.1. NC_008253.1.

Genome annotation databases

EnsemblBacteriaiABG71157; ABG71157; ECP_3175.
GeneIDi4188456.
KEGGiecp:ECP_3175.
PATRICi18197192. VBIEscCol77757_3215.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000247 Genomic DNA. Translation: ABG71157.1 .
RefSeqi YP_671058.1. NC_008253.1.

3D structure databases

ProteinModelPortali Q0TD22.
SMRi Q0TD22. Positions 27-372.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 362663.ECP_3175.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABG71157 ; ABG71157 ; ECP_3175 .
GeneIDi 4188456.
KEGGi ecp:ECP_3175.
PATRICi 18197192. VBIEscCol77757_3215.

Phylogenomic databases

eggNOGi COG2813.
HOGENOMi HOG000246323.
KOi K11391.
OMAi DIGARIM.
OrthoDBi EOG67X1ZC.

Enzyme and pathway databases

BioCyci ECOL362663:GIY5-3197-MONOMER.

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
HAMAPi MF_01859. 23SrRNA_methyltr_G.
InterProi IPR002052. DNA_methylase_N6_adenine_CS.
IPR017237. rRNA_m2G-MeTrfase_RsmD.
IPR029063. SAM-dependent_MTases-like.
IPR007848. Small_mtfrase_dom.
[Graphical view ]
Pfami PF05175. MTS. 1 hit.
[Graphical view ]
PIRSFi PIRSF037565. RRNA_m2G_Mtase_RsmD_prd. 1 hit.
SUPFAMi SSF53335. SSF53335. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Role of pathogenicity island-associated integrases in the genome plasticity of uropathogenic Escherichia coli strain 536."
    Hochhut B., Wilde C., Balling G., Middendorf B., Dobrindt U., Brzuszkiewicz E., Gottschalk G., Carniel E., Hacker J.
    Mol. Microbiol. 61:584-595(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 536 / UPEC.

Entry informationi

Entry nameiRLMG_ECOL5
AccessioniPrimary (citable) accession number: Q0TD22
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: September 5, 2006
Last modified: July 9, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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