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Q0TD22

- RLMG_ECOL5

UniProt

Q0TD22 - RLMG_ECOL5

Protein

Ribosomal RNA large subunit methyltransferase G

Gene

rlmG

Organism
Escherichia coli O6:K15:H31 (strain 536 / UPEC)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 54 (01 Oct 2014)
      Sequence version 1 (05 Sep 2006)
      Previous versions | rss
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    Functioni

    Specifically methylates the guanine in position 1835 (m2G1835) of 23S rRNA.UniRule annotation

    Catalytic activityi

    S-adenosyl-L-methionine + guanine(1835) in 23S rRNA = S-adenosyl-L-homocysteine + N(2)-methylguanine(1835) in 23S rRNA.UniRule annotation

    GO - Molecular functioni

    1. 23S rRNA (guanine(1835)-N(2))-methyltransferase activity Source: UniProtKB-EC
    2. nucleic acid binding Source: InterPro

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    rRNA processing

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Enzyme and pathway databases

    BioCyciECOL362663:GIY5-3197-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ribosomal RNA large subunit methyltransferase GUniRule annotation (EC:2.1.1.174UniRule annotation)
    Alternative name(s):
    23S rRNA m2G1835 methyltransferaseUniRule annotation
    rRNA (guanine-N(2)-)-methyltransferase RlmGUniRule annotation
    Gene namesi
    Name:rlmGUniRule annotation
    Ordered Locus Names:ECP_3175
    OrganismiEscherichia coli O6:K15:H31 (strain 536 / UPEC)
    Taxonomic identifieri362663 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
    ProteomesiUP000009182: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 378378Ribosomal RNA large subunit methyltransferase GPRO_0000366464Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi362663.ECP_3175.

    Structurei

    3D structure databases

    ProteinModelPortaliQ0TD22.
    SMRiQ0TD22. Positions 27-372.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the methyltransferase superfamily. RlmG family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2813.
    HOGENOMiHOG000246323.
    KOiK11391.
    OMAiDIGARIM.
    OrthoDBiEOG67X1ZC.

    Family and domain databases

    Gene3Di3.40.50.150. 1 hit.
    HAMAPiMF_01859. 23SrRNA_methyltr_G.
    InterProiIPR002052. DNA_methylase_N6_adenine_CS.
    IPR017237. rRNA_m2G-MeTrfase_RsmD.
    IPR029063. SAM-dependent_MTases-like.
    IPR007848. Small_mtfrase_dom.
    [Graphical view]
    PfamiPF05175. MTS. 1 hit.
    [Graphical view]
    PIRSFiPIRSF037565. RRNA_m2G_Mtase_RsmD_prd. 1 hit.
    SUPFAMiSSF53335. SSF53335. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q0TD22-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSHLDNGFRS LTLQRFPATD DVNPLQAWEA ADEYLLQQLD DTEIRGPVLI    50
    LNDAFGALSC ALAEHKPYSI GDSYISELAT RENLRLNGID ESSVKFLDST 100
    ADYPQQPGVV LIKVPKTLAL LEQQLRALRK VVTPDTRIIA GAKARDIHTS 150
    TLELFEKVLG PTTTTLAWKK ARLINCTFNE PPLVDAPQTV SWKLEGTDWT 200
    IHNHANVFSR TGLDIGARFF MQHLPENLEG EIVDLGCGNG VIGLTLLDKN 250
    PQAKVVFVDE SPMAVASSRL NVETNMPEAL DRCEFMINNA LSGVEPFRFN 300
    AVLCNPPFHQ QHALTDNVAW EMFHHARRCL KINGELYIVA NRHLDYFHKL 350
    KKIFGNCTTI ATNNKFVVLK AVKLGRRR 378
    Length:378
    Mass (Da):42,339
    Last modified:September 5, 2006 - v1
    Checksum:i15BB5B3E8B8BE9CE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000247 Genomic DNA. Translation: ABG71157.1.
    RefSeqiYP_671058.1. NC_008253.1.

    Genome annotation databases

    EnsemblBacteriaiABG71157; ABG71157; ECP_3175.
    GeneIDi4188456.
    KEGGiecp:ECP_3175.
    PATRICi18197192. VBIEscCol77757_3215.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000247 Genomic DNA. Translation: ABG71157.1 .
    RefSeqi YP_671058.1. NC_008253.1.

    3D structure databases

    ProteinModelPortali Q0TD22.
    SMRi Q0TD22. Positions 27-372.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 362663.ECP_3175.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABG71157 ; ABG71157 ; ECP_3175 .
    GeneIDi 4188456.
    KEGGi ecp:ECP_3175.
    PATRICi 18197192. VBIEscCol77757_3215.

    Phylogenomic databases

    eggNOGi COG2813.
    HOGENOMi HOG000246323.
    KOi K11391.
    OMAi DIGARIM.
    OrthoDBi EOG67X1ZC.

    Enzyme and pathway databases

    BioCyci ECOL362663:GIY5-3197-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.150. 1 hit.
    HAMAPi MF_01859. 23SrRNA_methyltr_G.
    InterProi IPR002052. DNA_methylase_N6_adenine_CS.
    IPR017237. rRNA_m2G-MeTrfase_RsmD.
    IPR029063. SAM-dependent_MTases-like.
    IPR007848. Small_mtfrase_dom.
    [Graphical view ]
    Pfami PF05175. MTS. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF037565. RRNA_m2G_Mtase_RsmD_prd. 1 hit.
    SUPFAMi SSF53335. SSF53335. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Role of pathogenicity island-associated integrases in the genome plasticity of uropathogenic Escherichia coli strain 536."
      Hochhut B., Wilde C., Balling G., Middendorf B., Dobrindt U., Brzuszkiewicz E., Gottschalk G., Carniel E., Hacker J.
      Mol. Microbiol. 61:584-595(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 536 / UPEC.

    Entry informationi

    Entry nameiRLMG_ECOL5
    AccessioniPrimary (citable) accession number: Q0TD22
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 24, 2009
    Last sequence update: September 5, 2006
    Last modified: October 1, 2014
    This is version 54 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3