ID   NANK_ECOL5              Reviewed;         291 AA.
AC   Q0TCP4;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 1.
DT   16-JUN-2009, entry version 19.
DE   RecName: Full=N-acetylmannosamine kinase;
DE            EC=2.7.1.60;
DE   AltName: Full=N-acetyl-D-mannosamine kinase;
DE   AltName: Full=ManNAc kinase;
GN   Name=nanK; OrderedLocusNames=ECP_3305;
OS   Escherichia coli O6:K15:H31 (strain 536 / UPEC).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=362663;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16879640; DOI=10.1111/j.1365-2958.2006.05255.x;
RA   Hochhut B., Wilde C., Balling G., Middendorf B., Dobrindt U.,
RA   Brzuszkiewicz E., Gottschalk G., Carniel E., Hacker J.;
RT   "Role of pathogenicity island-associated integrases in the genome
RT   plasticity of uropathogenic Escherichia coli strain 536.";
RL   Mol. Microbiol. 61:584-595(2006).
CC   -!- FUNCTION: Catalyzes the phosphorylation of N-acetylmannosamine
CC       (ManNAc) to ManNAc-6-P (By similarity).
CC   -!- CATALYTIC ACTIVITY: ATP + N-acyl-D-mannosamine = ADP + N-acyl-D-
CC       mannosamine 6-phosphate.
CC   -!- PATHWAY: Amino-sugar metabolism; N-acetylneuraminic acid
CC       degradation; D-fructose 6-phosphate from N-acetylneuraminic acid:
CC       step 2/5.
CC   -!- SUBUNIT: Homodimer (By similarity).
CC   -!- SIMILARITY: Belongs to the ROK (nagC/xylR) family. NanK subfamily.
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DR   EMBL; CP000247; ABG71285.1; -; Genomic_DNA.
DR   RefSeq; YP_671186.1; -.
DR   SMR; Q0TCP4; 1-289.
DR   GeneID; 4188825; -.
DR   GenomeReviews; CP000247_GR; ECP_3305.
DR   KEGG; ecp:ECP_3305; -.
DR   NMPDR; fig|340197.3.peg.4535; -.
DR   HOGENOM; Q0TCP4; -.
DR   OMA; Q0TCP4; EYQALEG.
DR   BioCyc; ECOL362663:ECP_3305-MON; -.
DR   GO; GO:0005524; F:ATP binding; IEA:HAMAP.
DR   GO; GO:0009384; F:N-acylmannosamine kinase activity; IEA:HAMAP.
DR   GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006051; P:N-acetylmannosamine metabolic process; IEA:HAMAP.
DR   HAMAP; MF_01234; -; 1.
DR   InterPro; IPR000600; ROK.
DR   Pfam; PF00480; ROK; 1.
DR   PROSITE; PS01125; ROK; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Carbohydrate metabolism; Complete proteome; Kinase;
KW   Metal-binding; Nucleotide-binding; Transferase; Zinc.
FT   CHAIN         1    291       N-acetylmannosamine kinase.
FT                                /FTId=PRO_0000301458.
FT   NP_BIND       5     12       ATP (Potential).
FT   NP_BIND     132    139       ATP (Potential).
FT   METAL       156    156       Zinc (By similarity).
FT   METAL       166    166       Zinc (By similarity).
FT   METAL       168    168       Zinc (By similarity).
FT   METAL       173    173       Zinc (By similarity).
SQ   SEQUENCE   291 AA;  29685 MW;  2EA97FAB54B1D7B8 CRC64;
     MTTLAIDIGG TKLAAALIGA DGQIRDRREL PTPASQTPQA LRDALSALVS PLQAHAQRVA
     IASTGIIRDG SLLALNPHNL GGLLHFPLVK TLEQLTNLPT IAINDAQAAA WAEYQALDGD
     ITDMVFITVS TGVGGGVVSG GKLRTGPGGL AGHIGHTLAD PHGPVCGCGR TGCVEAIASG
     RGIATAAQGE LAGANAKTIF TRAGQGDEQA QQLIHRSART LARLIADIKA TTDCQCVVVG
     GSVGLAEGYL ALVETYLAQE PAAFHVDLLA AHYRHDAGLL GAALLAQGEK L
//