Q0TCP4 (NANK_ECOL5) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 39.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: N-acetylmannosamine kinase EC=2.7.1.60 Alternative name(s): ManNAc kinase N-acetyl-D-mannosamine kinase | ||||
| Gene names |
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| Organism | Escherichia coli O6:K15:H31 (strain 536 / UPEC) [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 362663 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia |
Protein attributes
| Sequence length | 291 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Function | Catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P By similarity. HAMAP MF_01234 |
| Catalytic activity | ATP + N-acyl-D-mannosamine = ADP + N-acyl-D-mannosamine 6-phosphate. HAMAP MF_01234 |
| Pathway | Amino-sugar metabolism; N-acetylneuraminate degradation; D-fructose 6-phosphate from N-acetylneuraminate: step 2/5. HAMAP MF_01234 |
| Subunit structure | Homodimer By similarity. HAMAP MF_01234 |
| Sequence similarities | Belongs to the ROK (nagC/xylR) family. NanK subfamily. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Carbohydrate metabolism |
| Ligand | ATP-binding Metal-binding Nucleotide-binding Zinc |
| Molecular function | Kinase Transferase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | N-acetylneuraminate catabolic process Inferred from electronic annotation. Source: InterPro |
| Molecular function | ATP binding Inferred from electronic annotation. Source: UniProtKB-KW N-acylmannosamine kinase activityInferred from electronic annotation. Source: EC zinc ion bindingInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 291 | 291 | N-acetylmannosamine kinase HAMAP MF_01234 | PRO_0000301458 | |||||
Regions | |||||||||
| Nucleotide binding | 5 – 12 | 8 | ATP Potential | ||||||
| Nucleotide binding | 132 – 139 | 8 | ATP Potential | ||||||
Sites | |||||||||
| Metal binding | 156 | 1 | Zinc By similarity | ||||||
| Metal binding | 166 | 1 | Zinc By similarity | ||||||
| Metal binding | 168 | 1 | Zinc By similarity | ||||||
| Metal binding | 173 | 1 | Zinc By similarity | ||||||
Sequences
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References
| [1] | "Role of pathogenicity island-associated integrases in the genome plasticity of uropathogenic Escherichia coli strain 536." Hochhut B., Wilde C., Balling G., Middendorf B., Dobrindt U., Brzuszkiewicz E., Gottschalk G., Carniel E., Hacker J. Mol. Microbiol. 61:584-595(2006) [PubMed: 16879640] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 536 / UPEC. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | CP000247 Genomic DNA. Translation: ABG71285.1. |
| RefSeq | YP_671186.1. NC_008253.1. |
3D structure databases | |
| ProteinModelPortal | Q0TCP4. |
| SMR | Q0TCP4. Positions 1-289. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q0TCP4. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| EnsemblBacteria | EBESCT00000050335; EBESCP00000048524; EBESCG00000049383. |
| GeneID | 4188825. |
| GenomeReviews | Gene locus ECP_3305 in contig CP000247_GR. |
| KEGG | ecp:ECP_3305. |
| NMPDR | fig|340197.3.peg.4535. |
| PATRIC | 18197462. VBIEscCol77757_3348. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| eggNOG | COG1940. |
| GeneTree | EBGT00050000009665. |
| HOGENOM | HBG730260. |
| OMA | LRISQCR. |
| PhylomeDB | Q0TCP4. |
| ProtClustDB | PRK05082. |
Enzyme and pathway databases | |
| BioCyc | ECOL362663:ECP_3305-MONOMER. |
Family and domain databases | |
| HAMAP | MF_01234. ManNAc_kinase. [Tree] |
| InterPro | IPR023945. ManNAc_kinase_bac. IPR000600. ROK. [Graphical view] |
| KO | K00885. |
| Pfam | PF00480. ROK. 1 hit. [Graphical view] |
| PROSITE | PS01125. ROK. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | NANK_ECOL5 | ||||||||
| Accession | Primary (citable) accession number: Q0TCP4 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Prokaryotic Protein Annotation Program | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

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