Reviewed,
UniProtKB/Swiss-Prot Q0TCP4 (NANK_ECOL5)
Last modified
June 16, 2009.
Version 19.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: N-acetylmannosamine kinase EC=2.7.1.60 Alternative name(s): N-acetyl-D-mannosamine kinase ManNAc kinase | ||||
| Gene names |
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| Organism | Escherichia coli O6:K15:H31 (strain 536 / UPEC) [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 362663 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia |
Protein attributes
| Sequence length | 291 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | Catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P By similarity. |
| Catalytic activity | ATP + N-acyl-D-mannosamine = ADP + N-acyl-D-mannosamine 6-phosphate. HAMAP MF_01234 |
| Pathway | Amino-sugar metabolism; N-acetylneuraminic acid degradation; D-fructose 6-phosphate from N-acetylneuraminic acid: step 2/5. HAMAP MF_01234 |
| Subunit structure | Homodimer By similarity. |
| Sequence similarities | Belongs to the ROK (nagC/xylR) family. NanK subfamily. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Carbohydrate metabolism |
| Ligand | ATP-binding Metal-binding Nucleotide-binding Zinc |
| Molecular function | Kinase Transferase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | N-acetylmannosamine metabolic process Inferred from electronic annotation. Source: HAMAP |
| Molecular function | ATP binding Inferred from electronic annotation. Source: HAMAP N-acylmannosamine kinase activityInferred from electronic annotation. Source: HAMAP zinc ion bindingInferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 291 | 291 | N-acetylmannosamine kinase HAMAP MF_01234 | PRO_0000301458 | |||||
Regions | |||||||||
| Nucleotide binding | 5 – 12 | 8 | ATP Potential | ||||||
| Nucleotide binding | 132 – 139 | 8 | ATP Potential | ||||||
Sites | |||||||||
| Metal binding | 156 | 1 | Zinc By similarity | ||||||
| Metal binding | 166 | 1 | Zinc By similarity | ||||||
| Metal binding | 168 | 1 | Zinc By similarity | ||||||
| Metal binding | 173 | 1 | Zinc By similarity | ||||||
Sequences
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References
| [1] | "Role of pathogenicity island-associated integrases in the genome plasticity of uropathogenic Escherichia coli strain 536." Hochhut B., Wilde C., Balling G., Middendorf B., Dobrindt U., Brzuszkiewicz E., Gottschalk G., Carniel E., Hacker J. Mol. Microbiol. 61:584-595(2006) [PubMed: 16879640] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
Cross-references
Sequence databases | |
|---|---|
| CP000247 Genomic DNA. Translation: ABG71285.1. | |
| RefSeq | YP_671186.1. |
3D structure databases | |
| SMR | Q0TCP4. Positions 1-289. |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 4188825. |
| GenomeReviews | Gene locus ECP_3305 in contig CP000247_GR. |
| KEGG | ecp:ECP_3305. |
| NMPDR | fig|340197.3.peg.4535. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | Q0TCP4. |
| OMA | Q0TCP4. EYQALEG. |
Enzyme and pathway databases | |
| BioCyc | ECOL362663:ECP_3305-MON. |
Family and domain databases | |
| HAMAP | MF_01234. [Tree] |
| InterPro | IPR000600. ROK. [Graphical view] |
| Pfam | PF00480. ROK. 1 hit. [Graphical view] |
| PROSITE | PS01125. ROK. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | NANK_ECOL5 | ||||||||
| Accession | Primary (citable) accession number: Q0TCP4 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


