Q0TCP3 (NANE_ECOL5) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative N-acetylmannosamine-6-phosphate 2-epimerase
EC=5.1.3.9

Alternative name(s):
ManNAc-6-P epimerase

Gene names

Name:	nanE
Ordered Locus Names:	ECP_3306

Organism

Escherichia coli O6:K15:H31 (strain 536 / UPEC) [Complete proteome] [HAMAP]

Taxonomic identifier

362663 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia

Protein attributes

Sequence length	229 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P) Potential. HAMAP MF_01235
Catalytic activity	N-acyl-D-glucosamine 6-phosphate = N-acyl-D-mannosamine 6-phosphate. HAMAP MF_01235
Pathway	Amino-sugar metabolism; N-acetylneuraminate degradation; D-fructose 6-phosphate from N-acetylneuraminate: step 3/5. HAMAP MF_01235
Sequence similarities	Belongs to the nanE family.

Ontologies

Keywords
Biological process	Carbohydrate metabolism
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	N-acetylmannosamine metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	N-acylglucosamine-6-phosphate 2-epimerase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 229	229	Putative N-acetylmannosamine-6-phosphate 2-epimerase HAMAP MF_01235		PRO_0000301472

Sequences

	Sequence		Length	Mass (Da)
	Q0TCP3 [UniParc]. Last modified September 5, 2006. Version 1. Checksum: AB6CB3F36FEC0825	FASTA	229	24,074
	10 20 30 40 50 60 MSLLAQLDQK IAANGGLIVS CQPVPDSPLD KPEIVAAMAL AAEQAGAVAI RIEGVANLQA 70 80 90 100 110 120 TRAVVSVPII GIVKRDLEDS PVRITAYIED VDALAQAGAD IIAIDGTDRP RPVPVETLLA 130 140 150 160 170 180 RIHHHGLLAM TDCSTPEDGL ACQKLGAEII GTTLSGYTTP ETPEEPDLAL VKTLSDAGCR 190 200 210 220 VIAEGRYNTP AQAADAMRHG AWAVTVGSAI TRLEHICQWY NTAMKKAVL

References

[1]

"Role of pathogenicity island-associated integrases in the genome plasticity of uropathogenic Escherichia coli strain 536." Hochhut B., Wilde C., Balling G., Middendorf B., Dobrindt U., Brzuszkiewicz E., Gottschalk G., Carniel E., Hacker J. Mol. Microbiol. 61:584-595(2006) [PubMed: 16879640] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 536 / UPEC.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000247 Genomic DNA. Translation: ABG71286.1.
RefSeq	YP_671187.1. NC_008253.1.
3D structure databases
ProteinModelPortal	Q0TCP3.
SMR	Q0TCP3. Positions 1-227.
ModBase	Search...
Protein-protein interaction databases
STRING	Q0TCP3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBESCT00000047006; EBESCP00000045195; EBESCG00000046056.
GeneID	4188826.
GenomeReviews	Gene locus ECP_3306 in contig CP000247_GR.
KEGG	ecp:ECP_3306.
PATRIC	18197464. VBIEscCol77757_3349.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG3010.
GeneTree	EBGT00050000010584.
HOGENOM	HBG296941.
OMA	AMADCSN.
PhylomeDB	Q0TCP3.
ProtClustDB	PRK01130.
Enzyme and pathway databases
BioCyc	ECOL362663:ECP_3306-MONOMER.
Family and domain databases
HAMAP	MF_01235. ManNAc6P_epimer. [Tree]
InterPro	IPR013785. Aldolase_TIM. IPR007260. NanE. IPR011060. RibuloseP-bd_barrel. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KO	K01788.
Pfam	PF04131. NanE. 1 hit. [Graphical view]
SUPFAM	SSF51366. RibP_bind_barrel. 1 hit.
ProtoNet	Search...

Entry information

Entry name

NANE_ECOL5

Accession

Primary (citable) accession number: Q0TCP3

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 11, 2007
Last sequence update:	September 5, 2006
Last modified:	January 25, 2012
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program