Q0TBI8 (HLDD_ECOL5) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 41.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: ADP-L-glycero-D-manno-heptose-6-epimerase EC=5.1.3.20 Alternative name(s): ADP-L-glycero-beta-D-manno-heptose-6-epimerase Short name=ADP-glyceromanno-heptose 6-epimerase Short name=ADP-hep 6-epimerase Short name=AGME | ||||
| Gene names |
| ||||
| Organism | Escherichia coli O6:K15:H31 (strain 536 / UPEC) [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 362663 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia |
Protein attributes
| Sequence length | 310 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Function | Catalyzes the interconversion between ADP-D-glycero-beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose By similarity. HAMAP MF_01601 |
| Catalytic activity | ADP-D-glycero-D-manno-heptose = ADP-L-glycero-D-manno-heptose. HAMAP MF_01601 |
| Cofactor | Binds 1 NADP+ per subunit By similarity. HAMAP MF_01601 |
| Pathway | Nucleotide-sugar biosynthesis; ADP-L-glycero-beta-D-manno-heptose biosynthesis; ADP-L-glycero-beta-D-manno-heptose from D-glycero-beta-D-manno-heptose 7-phosphate: step 4/4. HAMAP MF_01601 |
| Subunit structure | Homopentamer By similarity. HAMAP MF_01601 |
| Domain | Contains a large N-terminal NADP-binding domain, and a smaller C-terminal substrate-binding domain By similarity. HAMAP MF_01601 |
| Sequence similarities | Belongs to the sugar epimerase family. HldD subfamily. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Carbohydrate metabolism |
| Ligand | NADP |
| Molecular function | Isomerase |
| PTM | Acetylation |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | carbohydrate metabolic process Inferred from electronic annotation. Source: UniProtKB-KW cellular metabolic processInferred from electronic annotation. Source: InterPro |
| Molecular function | ADP-glyceromanno-heptose 6-epimerase activity Inferred from electronic annotation. Source: EC NADP bindingInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 310 | 310 | ADP-L-glycero-D-manno-heptose-6-epimerase HAMAP MF_01601 | PRO_0000255730 | |||||
Regions | |||||||||
| Nucleotide binding | 10 – 11 | 2 | NADP By similarity | ||||||
| Nucleotide binding | 31 – 32 | 2 | NADP By similarity | ||||||
| Nucleotide binding | 75 – 79 | 5 | NADP By similarity | ||||||
| Region | 201 – 204 | 4 | Substrate binding By similarity | ||||||
Sites | |||||||||
| Active site | 140 | 1 | Proton acceptor By similarity | ||||||
| Active site | 178 | 1 | Proton acceptor By similarity | ||||||
| Binding site | 38 | 1 | NADP By similarity | ||||||
| Binding site | 53 | 1 | NADP By similarity | ||||||
| Binding site | 92 | 1 | NADP By similarity | ||||||
| Binding site | 144 | 1 | NADP By similarity | ||||||
| Binding site | 169 | 1 | Substrate By similarity | ||||||
| Binding site | 170 | 1 | NADP; via amide nitrogen By similarity | ||||||
| Binding site | 178 | 1 | NADP By similarity | ||||||
| Binding site | 180 | 1 | Substrate; via carbonyl oxygen By similarity | ||||||
| Binding site | 187 | 1 | Substrate By similarity | ||||||
| Binding site | 209 | 1 | Substrate By similarity | ||||||
| Binding site | 272 | 1 | Substrate By similarity | ||||||
Amino acid modifications | |||||||||
| Modified residue | 267 | 1 | N6-acetyllysine By similarity | ||||||
Sequences
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References
| [1] | "Role of pathogenicity island-associated integrases in the genome plasticity of uropathogenic Escherichia coli strain 536." Hochhut B., Wilde C., Balling G., Middendorf B., Dobrindt U., Brzuszkiewicz E., Gottschalk G., Carniel E., Hacker J. Mol. Microbiol. 61:584-595(2006) [PubMed: 16879640] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 536 / UPEC. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | CP000247 Genomic DNA. Translation: ABG71691.1. |
| RefSeq | YP_671592.1. NC_008253.1. |
3D structure databases | |
| ProteinModelPortal | Q0TBI8. |
| SMR | Q0TBI8. Positions 1-307. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q0TBI8. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| EnsemblBacteria | EBESCT00000046714; EBESCP00000044903; EBESCG00000045764. |
| GeneID | 4190289. |
| GenomeReviews | Gene locus ECP_3719 in contig CP000247_GR. |
| KEGG | ecp:ECP_3719. |
| PATRIC | 18198317. VBIEscCol77757_3768. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| eggNOG | COG0451. |
| GeneTree | EBGT00050000008810. |
| HOGENOM | HBG755066. |
| OMA | RRDFIYV. |
| PhylomeDB | Q0TBI8. |
| ProtClustDB | PRK11150. |
Enzyme and pathway databases | |
| BioCyc | ECOL362663:ECP_3719-MONOMER. |
Family and domain databases | |
| HAMAP | MF_01601. Heptose_epimerase. [Tree] |
| InterPro | IPR001509. Epimerase_deHydtase. IPR011912. Heptose_epim. IPR016040. NAD(P)-bd_dom. [Graphical view] |
| Gene3D | G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. |
| KO | K03274. |
| PANTHER | PTHR10366:SF29. Heptose_epim. 1 hit. |
| Pfam | PF01370. Epimerase. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR02197. Heptose_epim. 1 hit. |
| ProtoNet | Search... |
Entry information
| Entry name | HLDD_ECOL5 | ||||||||
| Accession | Primary (citable) accession number: Q0TBI8 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Prokaryotic Protein Annotation Program | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with