Reviewed, UniProtKB/Swiss-Prot Q0TB37 (ADEC_ECOL5)

Names and origin

Protein names

Recommended name:
    Adenine deaminase
      Short name=Adenase
      Short name=Adenine aminase
    EC=3.5.4.2

Gene names

Name:	ade
Ordered Locus Names:	ECP_3871

Organism

Escherichia coli O6:K15:H31 (strain 536 / UPEC) [Complete proteome] [HAMAP]

Taxonomic identifier

362663 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia

Protein attributes

Sequence length	588 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Adenine + H2O = hypoxanthine + NH3. HAMAP MF_01518
Cofactor	Manganese By similarity.
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the adenine deaminase family.

Ontologies

Keywords
Ligand	Manganese
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	adenine catabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	adenine deaminase activity Inferred from electronic annotation. Source: HAMAP manganese ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 588	588	Adenine deaminase HAMAP MF_01518		PRO_0000296725

Sequences

	Sequence		Length	Mass (Da)
	Q0TB37-1 [UniParc]. Last modified September 5, 2006. Version 1. Checksum: 74E392C2AD94D2D7	FASTA	588	63,772
	10 20 30 40 50 60 MNNSINHKFH HISRAEYQEL LAVSRGDAVA DYIIDNVSIL DLINGGEISG PIVIKGRYIA 70 80 90 100 110 120 GVGAEYADAP ALQRIDARGA TAVPGFIDAH LHIESSMMTP VTFETATLPR GLTTVICDPH 130 140 150 160 170 180 EIVNVMGEAG FAWFARCAEQ ARQNQYLQVS SCVPALEGCD VNGASFTLEQ MLAWRDHPQV 190 200 210 220 230 240 TGLAEMMDYP GVISGQNALL DKLDAFRHLT LDGHCPGLGG KELNAYIAAG IENCHESYQL 250 260 270 280 290 300 EEGRRKLQLG MSLMIREGSA ARNLNALAPL INEFNSPQCM LCTDDRNPWE IAHEGHIDAL 310 320 330 340 350 360 IRRLIEQHNV PLHVAYRVAS WSTARHFGLN HLGLLAPGKQ ADIVLLSDAR KVTVQQVLVK 370 380 390 400 410 420 GEPIDAQTLQ AEESARLAQS APPYGNTIDR QPVSASDFAL QFTPGKRYRV IEVIHNELIT 430 440 450 460 470 480 HSRSSVYSEN GFDRDDVCFI AVLERYGQRL APACGLLGGF GLNEGALAAT VSHDSHNIVV 490 500 510 520 530 540 IGRSAEEMAL AVNQVIQDGG GLCVVRNGQV QSHLPLPIAG LMSTDTAQSL AEQIDALKAA 550 560 570 580 ARECGPLPDE PFIQMAFLSL PVIPALKLTS QGLFDGEKFA FTTLEVTE

References

[1]

"Role of pathogenicity island-associated integrases in the genome plasticity of uropathogenic Escherichia coli strain 536." Hochhut B., Wilde C., Balling G., Middendorf B., Dobrindt U., Brzuszkiewicz E., Gottschalk G., Carniel E., Hacker J. Mol. Microbiol. 61:584-595(2006) [PubMed: 16879640] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000247 Genomic DNA. Translation: ABG71842.1.
RefSeq	YP_671743.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	4189060.
GenomeReviews	Gene locus ECP_3871 in contig CP000247_GR.
KEGG	ecp:ECP_3871.
NMPDR	fig|340197.3.peg.483.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q0TB37.
OMA	Q0TB37. IMIREGS.
Enzyme and pathway databases
BioCyc	ECOL362663:ECP_3871-MON.
Family and domain databases
HAMAP	MF_01518. [Tree]
InterPro	IPR006679. Adenine_deam. IPR006680. Amidohydro_1. [Graphical view]
Pfam	PF01979. Amidohydro_1. 1 hit. [Graphical view]
TIGRFAMs	TIGR01178. ade. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ADEC_ECOL5

Accession

Primary (citable) accession number: Q0TB37

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 24, 2007
Last sequence update:	September 5, 2006
Last modified:	May 5, 2009
This is version 20 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)