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Q0TB37 (ADEC_ECOL5) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 41. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Adenine deaminase
Short name=Adenase
Short name=Adenine aminase
EC=3.5.4.2
Gene names
Name:ade
Ordered Locus Names:ECP_3871
OrganismEscherichia coli O6:K15:H31 (strain 536 / UPEC) [Complete proteome] [HAMAP]
Taxonomic identifier362663 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia

Protein attributes

Sequence length588 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Adenine + H2O = hypoxanthine + NH3. HAMAP MF_01518

Cofactor

Manganese By similarity. HAMAP MF_01518

Subunit structure

Homodimer By similarity. HAMAP MF_01518

Sequence similarities

Belongs to the adenine deaminase family.

Ontologies

Keywords
   LigandManganese
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processadenine catabolic process

Inferred from electronic annotation. Source: InterPro

   Molecular functionadenine deaminase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 588588Adenine deaminase HAMAP MF_01518
PRO_0000296725

Sequences

Sequence LengthMass (Da)Tools
Q0TB37 [UniParc].

Last modified September 5, 2006. Version 1.
Checksum: 74E392C2AD94D2D7

FASTA58863,772
        10         20         30         40         50         60 
MNNSINHKFH HISRAEYQEL LAVSRGDAVA DYIIDNVSIL DLINGGEISG PIVIKGRYIA 

        70         80         90        100        110        120 
GVGAEYADAP ALQRIDARGA TAVPGFIDAH LHIESSMMTP VTFETATLPR GLTTVICDPH 

       130        140        150        160        170        180 
EIVNVMGEAG FAWFARCAEQ ARQNQYLQVS SCVPALEGCD VNGASFTLEQ MLAWRDHPQV 

       190        200        210        220        230        240 
TGLAEMMDYP GVISGQNALL DKLDAFRHLT LDGHCPGLGG KELNAYIAAG IENCHESYQL 

       250        260        270        280        290        300 
EEGRRKLQLG MSLMIREGSA ARNLNALAPL INEFNSPQCM LCTDDRNPWE IAHEGHIDAL 

       310        320        330        340        350        360 
IRRLIEQHNV PLHVAYRVAS WSTARHFGLN HLGLLAPGKQ ADIVLLSDAR KVTVQQVLVK 

       370        380        390        400        410        420 
GEPIDAQTLQ AEESARLAQS APPYGNTIDR QPVSASDFAL QFTPGKRYRV IEVIHNELIT 

       430        440        450        460        470        480 
HSRSSVYSEN GFDRDDVCFI AVLERYGQRL APACGLLGGF GLNEGALAAT VSHDSHNIVV 

       490        500        510        520        530        540 
IGRSAEEMAL AVNQVIQDGG GLCVVRNGQV QSHLPLPIAG LMSTDTAQSL AEQIDALKAA 

       550        560        570        580 
ARECGPLPDE PFIQMAFLSL PVIPALKLTS QGLFDGEKFA FTTLEVTE

« Hide

References

[1]"Role of pathogenicity island-associated integrases in the genome plasticity of uropathogenic Escherichia coli strain 536."
Hochhut B., Wilde C., Balling G., Middendorf B., Dobrindt U., Brzuszkiewicz E., Gottschalk G., Carniel E., Hacker J.
Mol. Microbiol. 61:584-595(2006) [PubMed: 16879640] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 536 / UPEC.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000247 Genomic DNA. Translation: ABG71842.1.
RefSeqYP_671743.1. NC_008253.1.

3D structure databases

ProteinModelPortalQ0TB37.
SMRQ0TB37. Positions 29-121.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ0TB37.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBESCT00000048987; EBESCP00000047176; EBESCG00000048035.
GeneID4189060.
GenomeReviewsGene locus ECP_3871 in contig CP000247_GR.
KEGGecp:ECP_3871.
NMPDRfig|340197.3.peg.483.
PATRIC18198606. VBIEscCol77757_3911.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1001.
GeneTreeEBGT00050000011385.
HOGENOMHBG725357.
OMAGKIITEH.
PhylomeDBQ0TB37.
ProtClustDBPRK10027.

Enzyme and pathway databases

BioCycECOL362663:ECP_3871-MONOMER.

Family and domain databases

HAMAPMF_01518. Adenine_deamin.
[Tree]
InterProIPR006679. Adenine_deam.
IPR006680. Amidohydro_1.
IPR011059. Metal-dep_hydrolase_composite.
[Graphical view]
KOK01486.
PfamPF01979. Amidohydro_1. 1 hit.
[Graphical view]
SUPFAMSSF51338. Metalo_hydrolase. 1 hit.
TIGRFAMsTIGR01178. Ade. 1 hit.
ProtoNetSearch...

Entry information

Entry nameADEC_ECOL5
AccessionPrimary (citable) accession number: Q0TB37
Entry history
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: September 5, 2006
Last modified: January 25, 2012
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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