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Q0TB30 (Q0TB30_ECOL5) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Acetolactate synthase RuleBase RU003591
EC=2.2.1.6 RuleBase RU003591
Gene names
Ordered Locus Names:ECP_3878
OrganismEscherichia coli O6:K15:H31 (strain 536 / UPEC) [Complete proteome] [HAMAP] EMBL ABG71849.1
Taxonomic identifier362663 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia ›

Protein attributes

Sequence length562 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

2 pyruvate = 2-acetolactate + CO2.

Cofactor

Binds 1 magnesium ion per subunit By similarity.

Binds 1 thiamine pyrophosphate per subunit By similarity.

Pathway

Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 1/4.

Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 1/4.

Sequence similarities

Belongs to the TPP enzyme family. RuleBase RU003702

Sequences

Sequence LengthMass (Da)Tools
Q0TB30 [UniParc].

Last modified September 5, 2006. Version 1.
Checksum: 3112559DCE74DEB9

FASTA56260,414
        10         20         30         40         50         60 
MASSGTTSTR KRFTGAEFIV HFLEQQGIKI VTGIPGGSIL PVYDALSQST QIRHILARHE 

        70         80         90        100        110        120 
QGAGFIAQGM ARTDGKPAVC MACSGPGATN LVTAIADARL DSIPLICITG QVSASMIGTD 

       130        140        150        160        170        180 
AFQEVDTYGI SIPITKHNYL VRHIEELPQV MSDAFRIAQS GRPGPVWIDI PKDVQTAVFE 

       190        200        210        220        230        240 
IETQPAMAEK AAAPAFSEES IRDAAAMINA AKRPVLYLGG GVINAPARVR ELAEKAQLPT 

       250        260        270        280        290        300 
TMTLMALGML PKAHPLSLGM LGMHGVRSTN YILQEADLLI VLGARFDDRA IGKTEQFCPN 

       310        320        330        340        350        360 
AKIIHVDIDR AELGKIKQPH VAIQADVDDV LAQLIPLVEA QPRAEWHQLV ADLQREFPCP 

       370        380        390        400        410        420 
IPKACDPLSH YGLINAVAAC VDDNAIITTD VGQHQMWTAQ AYPLNRPRQW LTSGGLGTMG 

       430        440        450        460        470        480 
FGLPAAIGAA LANPDRKVLC FSGDGSLMMN IQEMATASEN QLDVKIILMN NEALGLVHQQ 

       490        500        510        520        530        540 
QSLFYKQGVF AATYPGKINF MQIAAGFGLE TCDLNNEADP QAALQEIINR PGPALIHVRI 

       550        560 
DAEEKVYPMV PPGAANTEMV GE

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References

[1]"Role of pathogenicity island-associated integrases in the genome plasticity of uropathogenic Escherichia coli strain 536."
Hochhut B., Wilde C., Balling G., Middendorf B., Dobrindt U., Brzuszkiewicz E., Gottschalk G., Carniel E., Hacker J.
Mol. Microbiol. 61:584-595(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 536 / UPEC.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000247 Genomic DNA. Translation: ABG71849.1.
RefSeqYP_671750.1. NC_008253.1.

3D structure databases

ProteinModelPortalQ0TB30.
ModBaseSearch...

Protein-protein interaction databases

STRING362663.ECP_3878.
Q0TB30.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABG71849; ABG71849; ECP_3878.
GeneID4189067.
KEGGecp:ECP_3878.
PATRIC18198620. VBIEscCol77757_3918.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0028.
HOGENOMHOG000258448.
KOK01652.
OMADSAIITT.
PhylomeDBQ0TB30.
ProtClustDBPRK08155.

Enzyme and pathway databases

BioCycECOL362663:GIY5-3907-MONOMER.
UniPathwayUPA00047; UER00055.
UPA00049; UER00059.

Family and domain databases

InterProIPR012846. Acetolactate_synth_lsu.
IPR012000. Thiamin_PyroP_enz_cen_dom.
IPR012001. Thiamin_PyroP_enz_TPP-bd_dom.
IPR000399. TPP-bd_CS.
IPR011766. TPP_enzyme-bd_C.
[Graphical view]
PANTHERPTHR18968:SF13. PTHR18968:SF13. 1 hit.
PfamPF02775. TPP_enzyme_C. 1 hit.
PF00205. TPP_enzyme_M. 1 hit.
PF02776. TPP_enzyme_N. 1 hit.
[Graphical view]
TIGRFAMsTIGR00118. acolac_lg. 1 hit.
PROSITEPS00187. TPP_ENZYMES. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameQ0TB30_ECOL5
AccessionPrimary (citable) accession number: Q0TB30
Entry history
Integrated into UniProtKB/TrEMBL: September 5, 2006
Last sequence update: September 5, 2006
Last modified: May 1, 2013
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry info