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Q0TB30

- Q0TB30_ECOL5

UniProt

Q0TB30 - Q0TB30_ECOL5

Protein

Acetolactate synthase

Gene

ECP_3878

Organism
Escherichia coli O6:K15:H31 (strain 536 / UPEC)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 67 (01 Oct 2014)
      Sequence version 1 (05 Sep 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    2 pyruvate = 2-acetolactate + CO2.UniRule annotation

    Cofactori

    Binds 1 magnesium ion per subunit.UniRule annotation
    Binds 1 magnesium ion per subunit By similarity.
    Binds 1 thiamine pyrophosphate per subunit.UniRule annotation
    Binds 1 thiamine pyrophosphate per subunit By similarity.

    Pathwayi

    GO - Molecular functioni

    1. acetolactate synthase activity Source: UniProtKB-EC
    2. flavin adenine dinucleotide binding Source: InterPro
    3. magnesium ion binding Source: InterPro
    4. thiamine pyrophosphate binding Source: InterPro

    GO - Biological processi

    1. isoleucine biosynthetic process Source: UniProtKB-UniPathway
    2. valine biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    TransferaseUniRule annotationImported

    Keywords - Biological processi

    Amino-acid biosynthesis, Branched-chain amino acid biosynthesisUniRule annotation

    Keywords - Ligandi

    MagnesiumUniRule annotation, Metal-bindingUniRule annotation, Thiamine pyrophosphateUniRule annotation

    Enzyme and pathway databases

    BioCyciECOL362663:GIY5-3907-MONOMER.
    UniPathwayiUPA00047; UER00055.
    UPA00049; UER00059.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Acetolactate synthaseUniRule annotation (EC:2.2.1.6UniRule annotation)
    Gene namesi
    Ordered Locus Names:ECP_3878Imported
    OrganismiEscherichia coli O6:K15:H31 (strain 536 / UPEC)Imported
    Taxonomic identifieri362663 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
    ProteomesiUP000009182: Chromosome

    Interactioni

    Protein-protein interaction databases

    STRINGi362663.ECP_3878.

    Structurei

    3D structure databases

    ProteinModelPortaliQ0TB30.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the TPP enzyme family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0028.
    HOGENOMiHOG000258448.
    KOiK01652.
    OMAiANAVWRI.
    OrthoDBiEOG6KT2NW.

    Family and domain databases

    Gene3Di3.40.50.1220. 1 hit.
    3.40.50.970. 2 hits.
    InterProiIPR012846. Acetolactate_synth_lsu.
    IPR029035. DHS-like_NAD/FAD-binding_dom.
    IPR029061. THDP-binding.
    IPR012000. Thiamin_PyroP_enz_cen_dom.
    IPR012001. Thiamin_PyroP_enz_TPP-bd_dom.
    IPR000399. TPP-bd_CS.
    IPR011766. TPP_enzyme-bd_C.
    [Graphical view]
    PfamiPF02775. TPP_enzyme_C. 1 hit.
    PF00205. TPP_enzyme_M. 1 hit.
    PF02776. TPP_enzyme_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF52467. SSF52467. 1 hit.
    SSF52518. SSF52518. 2 hits.
    TIGRFAMsiTIGR00118. acolac_lg. 1 hit.
    PROSITEiPS00187. TPP_ENZYMES. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q0TB30-1 [UniParc]FASTAAdd to Basket

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    MASSGTTSTR KRFTGAEFIV HFLEQQGIKI VTGIPGGSIL PVYDALSQST    50
    QIRHILARHE QGAGFIAQGM ARTDGKPAVC MACSGPGATN LVTAIADARL 100
    DSIPLICITG QVSASMIGTD AFQEVDTYGI SIPITKHNYL VRHIEELPQV 150
    MSDAFRIAQS GRPGPVWIDI PKDVQTAVFE IETQPAMAEK AAAPAFSEES 200
    IRDAAAMINA AKRPVLYLGG GVINAPARVR ELAEKAQLPT TMTLMALGML 250
    PKAHPLSLGM LGMHGVRSTN YILQEADLLI VLGARFDDRA IGKTEQFCPN 300
    AKIIHVDIDR AELGKIKQPH VAIQADVDDV LAQLIPLVEA QPRAEWHQLV 350
    ADLQREFPCP IPKACDPLSH YGLINAVAAC VDDNAIITTD VGQHQMWTAQ 400
    AYPLNRPRQW LTSGGLGTMG FGLPAAIGAA LANPDRKVLC FSGDGSLMMN 450
    IQEMATASEN QLDVKIILMN NEALGLVHQQ QSLFYKQGVF AATYPGKINF 500
    MQIAAGFGLE TCDLNNEADP QAALQEIINR PGPALIHVRI DAEEKVYPMV 550
    PPGAANTEMV GE 562
    Length:562
    Mass (Da):60,414
    Last modified:September 5, 2006 - v1
    Checksum:i3112559DCE74DEB9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000247 Genomic DNA. Translation: ABG71849.1.
    RefSeqiYP_671750.1. NC_008253.1.

    Genome annotation databases

    EnsemblBacteriaiABG71849; ABG71849; ECP_3878.
    GeneIDi4189067.
    KEGGiecp:ECP_3878.
    PATRICi18198620. VBIEscCol77757_3918.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000247 Genomic DNA. Translation: ABG71849.1 .
    RefSeqi YP_671750.1. NC_008253.1.

    3D structure databases

    ProteinModelPortali Q0TB30.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 362663.ECP_3878.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABG71849 ; ABG71849 ; ECP_3878 .
    GeneIDi 4189067.
    KEGGi ecp:ECP_3878.
    PATRICi 18198620. VBIEscCol77757_3918.

    Phylogenomic databases

    eggNOGi COG0028.
    HOGENOMi HOG000258448.
    KOi K01652.
    OMAi ANAVWRI.
    OrthoDBi EOG6KT2NW.

    Enzyme and pathway databases

    UniPathwayi UPA00047 ; UER00055 .
    UPA00049 ; UER00059 .
    BioCyci ECOL362663:GIY5-3907-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.1220. 1 hit.
    3.40.50.970. 2 hits.
    InterProi IPR012846. Acetolactate_synth_lsu.
    IPR029035. DHS-like_NAD/FAD-binding_dom.
    IPR029061. THDP-binding.
    IPR012000. Thiamin_PyroP_enz_cen_dom.
    IPR012001. Thiamin_PyroP_enz_TPP-bd_dom.
    IPR000399. TPP-bd_CS.
    IPR011766. TPP_enzyme-bd_C.
    [Graphical view ]
    Pfami PF02775. TPP_enzyme_C. 1 hit.
    PF00205. TPP_enzyme_M. 1 hit.
    PF02776. TPP_enzyme_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52467. SSF52467. 1 hit.
    SSF52518. SSF52518. 2 hits.
    TIGRFAMsi TIGR00118. acolac_lg. 1 hit.
    PROSITEi PS00187. TPP_ENZYMES. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Role of pathogenicity island-associated integrases in the genome plasticity of uropathogenic Escherichia coli strain 536."
      Hochhut B., Wilde C., Balling G., Middendorf B., Dobrindt U., Brzuszkiewicz E., Gottschalk G., Carniel E., Hacker J.
      Mol. Microbiol. 61:584-595(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 536 / UPECImported.

    Entry informationi

    Entry nameiQ0TB30_ECOL5
    AccessioniPrimary (citable) accession number: Q0TB30
    Entry historyi
    Integrated into UniProtKB/TrEMBL: September 5, 2006
    Last sequence update: September 5, 2006
    Last modified: October 1, 2014
    This is version 67 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3