ID   RHAA_ECOL5              Reviewed;         419 AA.
AC   Q0TAG0;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 1.
DT   16-JUN-2009, entry version 22.
DE   RecName: Full=L-rhamnose isomerase;
DE            EC=5.3.1.14;
GN   Name=rhaA; OrderedLocusNames=ECP_4113;
OS   Escherichia coli O6:K15:H31 (strain 536 / UPEC).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=362663;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16879640; DOI=10.1111/j.1365-2958.2006.05255.x;
RA   Hochhut B., Wilde C., Balling G., Middendorf B., Dobrindt U.,
RA   Brzuszkiewicz E., Gottschalk G., Carniel E., Hacker J.;
RT   "Role of pathogenicity island-associated integrases in the genome
RT   plasticity of uropathogenic Escherichia coli strain 536.";
RL   Mol. Microbiol. 61:584-595(2006).
CC   -!- CATALYTIC ACTIVITY: L-rhamnose = L-rhamnulose.
CC   -!- COFACTOR: Binds 1 manganese ion per subunit (By similarity).
CC   -!- PATHWAY: Carbohydrate degradation; L-rhamnose degradation;
CC       glycerone phosphate from L-rhamnose: step 1/3.
CC   -!- SUBUNIT: Homotetramer (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the rhamnose isomerase family.
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DR   EMBL; CP000247; ABG72069.1; -; Genomic_DNA.
DR   RefSeq; YP_671970.1; -.
DR   SMR; Q0TAG0; 1-418.
DR   GeneID; 4189733; -.
DR   GenomeReviews; CP000247_GR; ECP_4113.
DR   KEGG; ecp:ECP_4113; -.
DR   HOGENOM; Q0TAG0; -.
DR   OMA; Q0TAG0; GSHEFYM.
DR   BioCyc; ECOL362663:ECP_4113-MON; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0008740; F:L-rhamnose isomerase activity; IEA:HAMAP.
DR   GO; GO:0030145; F:manganese ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0019299; P:rhamnose metabolic process; IEA:HAMAP.
DR   HAMAP; MF_00541; -; 1.
DR   InterPro; IPR009308; Rhamnose_isomerase.
DR   InterPro; IPR013022; Xyl_isomerase-like_TIM-brl.
DR   Gene3D; G3DSA:3.20.20.150; Xyl_isomerase-like_TIM-brl; 1.
DR   Pfam; PF06134; RhaA; 1.
DR   TIGRFAMs; TIGR01748; rhaA; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Cytoplasm; Isomerase; Manganese; Metal-binding;
KW   Rhamnose metabolism.
FT   CHAIN         1    419       L-rhamnose isomerase.
FT                                /FTId=PRO_1000017717.
FT   METAL       262    262       Manganese (By similarity).
FT   METAL       294    294       Manganese (By similarity).
FT   METAL       296    296       Manganese (By similarity).
SQ   SEQUENCE   419 AA;  47308 MW;  A89D957E05884BCB CRC64;
     MTTQLEQAWE LAKQRFAAVG IDVEEALRQL DRLPVSMHCW QGDDVSGFEN PEGSLTGGIQ
     ATGNYPGKAR NASELRADLE QAMRLIPGPK RLNLHAIYLE SDTPVSRDQI KPEHFKNWVE
     WAKANQLGLD FNPSCFSHPL SADGFTLSHA DDRIRQFWID HCKASRRVSA YFGEQLGTPS
     VMNIWIPDGM KDITVDRLAP RQRLLAALDE VISEKLNPAH HIDAVESKLF GIGAESYTVG
     SNEFYLGYAT SRQTALCLDA GHFHPTEVIS DKISAAMLYV PQLLLHVSRP VRWDSDHVVL
     LDDETQAIAS EIVRHDLFDR VHIGLDFFDA SINRIAAWVI GTRNMKKALL RALLEPTAEL
     RKLEAAGDYT ARLALLEEQK SLPWQAVWEM YCQRHDTPAG SEWLENVRTY EKEILSRRG
//