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Q0TAG0 (RHAA_ECOL5) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 42. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
L-rhamnose isomerase
EC=5.3.1.14
Gene names
Name:rhaA
Ordered Locus Names:ECP_4113
OrganismEscherichia coli O6:K15:H31 (strain 536 / UPEC) [Complete proteome] [HAMAP]
Taxonomic identifier362663 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia

Protein attributes

Sequence length419 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

L-rhamnose = L-rhamnulose. HAMAP MF_00541

Cofactor

Binds 1 manganese ion per subunit By similarity. HAMAP MF_00541

Pathway

Carbohydrate degradation; L-rhamnose degradation; glycerone phosphate from L-rhamnose: step 1/3. HAMAP MF_00541

Subunit structure

Homotetramer By similarity. HAMAP MF_00541

Subcellular location

Cytoplasm By similarity HAMAP MF_00541.

Sequence similarities

Belongs to the rhamnose isomerase family.

Ontologies

Keywords
   Biological processRhamnose metabolism
   Cellular componentCytoplasm
   LigandManganese
Metal-binding
   Molecular functionIsomerase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processrhamnose metabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionL-rhamnose isomerase activity

Inferred from electronic annotation. Source: EC

manganese ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 419419L-rhamnose isomerase HAMAP MF_00541
PRO_1000017717

Sites

Metal binding2621Manganese By similarity
Metal binding2941Manganese By similarity
Metal binding2961Manganese By similarity

Sequences

Sequence LengthMass (Da)Tools
Q0TAG0 [UniParc].

Last modified September 5, 2006. Version 1.
Checksum: A89D957E05884BCB

FASTA41947,308
        10         20         30         40         50         60 
MTTQLEQAWE LAKQRFAAVG IDVEEALRQL DRLPVSMHCW QGDDVSGFEN PEGSLTGGIQ 

        70         80         90        100        110        120 
ATGNYPGKAR NASELRADLE QAMRLIPGPK RLNLHAIYLE SDTPVSRDQI KPEHFKNWVE 

       130        140        150        160        170        180 
WAKANQLGLD FNPSCFSHPL SADGFTLSHA DDRIRQFWID HCKASRRVSA YFGEQLGTPS 

       190        200        210        220        230        240 
VMNIWIPDGM KDITVDRLAP RQRLLAALDE VISEKLNPAH HIDAVESKLF GIGAESYTVG 

       250        260        270        280        290        300 
SNEFYLGYAT SRQTALCLDA GHFHPTEVIS DKISAAMLYV PQLLLHVSRP VRWDSDHVVL 

       310        320        330        340        350        360 
LDDETQAIAS EIVRHDLFDR VHIGLDFFDA SINRIAAWVI GTRNMKKALL RALLEPTAEL 

       370        380        390        400        410 
RKLEAAGDYT ARLALLEEQK SLPWQAVWEM YCQRHDTPAG SEWLENVRTY EKEILSRRG

« Hide

References

[1]"Role of pathogenicity island-associated integrases in the genome plasticity of uropathogenic Escherichia coli strain 536."
Hochhut B., Wilde C., Balling G., Middendorf B., Dobrindt U., Brzuszkiewicz E., Gottschalk G., Carniel E., Hacker J.
Mol. Microbiol. 61:584-595(2006) [PubMed: 16879640] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 536 / UPEC.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000247 Genomic DNA. Translation: ABG72069.1.
RefSeqYP_671970.1. NC_008253.1.

3D structure databases

ProteinModelPortalQ0TAG0.
SMRQ0TAG0. Positions 3-418.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ0TAG0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBESCT00000049645; EBESCP00000047834; EBESCG00000048693.
GeneID4189733.
GenomeReviewsGene locus ECP_4113 in contig CP000247_GR.
KEGGecp:ECP_4113.
PATRIC18199131. VBIEscCol77757_4158.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG4806.
GeneTreeEBGT00050000011577.
HOGENOMHBG313138.
OMAVNLHAIY.
PhylomeDBQ0TAG0.
ProtClustDBPRK01076.

Enzyme and pathway databases

BioCycECOL362663:ECP_4113-MONOMER.

Family and domain databases

HAMAPMF_00541. RhaA.
[Tree]
InterProIPR009308. Rhamnose_isomerase.
IPR013022. Xyl_isomerase-like_TIM-brl.
[Graphical view]
Gene3DG3DSA:3.20.20.150. Xyl_isomerase-like_TIM-brl. 1 hit.
KOK01813.
PfamPF06134. RhaA. 1 hit.
[Graphical view]
SUPFAMSSF51658. Xyl_isomerase-like_TIM-brl. 1 hit.
TIGRFAMsTIGR01748. RhaA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameRHAA_ECOL5
AccessionPrimary (citable) accession number: Q0TAG0
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: September 5, 2006
Last modified: January 25, 2012
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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