Reviewed, UniProtKB/Swiss-Prot Q0TAG0 (RHAA_ECOL5)

Names and origin

Protein names

Recommended name:
    L-rhamnose isomerase
    EC=5.3.1.14

Gene names

Name:	rhaA
Ordered Locus Names:	ECP_4113

Organism

Escherichia coli O6:K15:H31 (strain 536 / UPEC) [Complete proteome] [HAMAP]

Taxonomic identifier

362663 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia

Protein attributes

Sequence length	419 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	L-rhamnose = L-rhamnulose. HAMAP MF_00541
Cofactor	Binds 1 manganese ion per subunit By similarity.
Pathway	Carbohydrate degradation; L-rhamnose degradation; glycerone phosphate from L-rhamnose: step 1/3. HAMAP MF_00541
Subunit structure	Homotetramer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the rhamnose isomerase family.

Ontologies

Keywords
Biological process	Rhamnose metabolism
Cellular component	Cytoplasm
Ligand	Manganese Metal-binding
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	rhamnose metabolic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	L-rhamnose isomerase activity Inferred from electronic annotation. Source: HAMAP manganese ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 419	419	L-rhamnose isomerase HAMAP MF_00541		PRO_1000017717
Sites
	Metal binding	262	1	Manganese By similarity
	Metal binding	294	1	Manganese By similarity
	Metal binding	296	1	Manganese By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q0TAG0-1 [UniParc]. Last modified September 5, 2006. Version 1. Checksum: A89D957E05884BCB	FASTA	419	47,308
	10 20 30 40 50 60 MTTQLEQAWE LAKQRFAAVG IDVEEALRQL DRLPVSMHCW QGDDVSGFEN PEGSLTGGIQ 70 80 90 100 110 120 ATGNYPGKAR NASELRADLE QAMRLIPGPK RLNLHAIYLE SDTPVSRDQI KPEHFKNWVE 130 140 150 160 170 180 WAKANQLGLD FNPSCFSHPL SADGFTLSHA DDRIRQFWID HCKASRRVSA YFGEQLGTPS 190 200 210 220 230 240 VMNIWIPDGM KDITVDRLAP RQRLLAALDE VISEKLNPAH HIDAVESKLF GIGAESYTVG 250 260 270 280 290 300 SNEFYLGYAT SRQTALCLDA GHFHPTEVIS DKISAAMLYV PQLLLHVSRP VRWDSDHVVL 310 320 330 340 350 360 LDDETQAIAS EIVRHDLFDR VHIGLDFFDA SINRIAAWVI GTRNMKKALL RALLEPTAEL 370 380 390 400 410 RKLEAAGDYT ARLALLEEQK SLPWQAVWEM YCQRHDTPAG SEWLENVRTY EKEILSRRG

References

[1]

"Role of pathogenicity island-associated integrases in the genome plasticity of uropathogenic Escherichia coli strain 536." Hochhut B., Wilde C., Balling G., Middendorf B., Dobrindt U., Brzuszkiewicz E., Gottschalk G., Carniel E., Hacker J. Mol. Microbiol. 61:584-595(2006) [PubMed: 16879640] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000247 Genomic DNA. Translation: ABG72069.1.
RefSeq	YP_671970.1.
3D structure databases
SMR	Q0TAG0. Positions 1-418.
ModBase	Search...
Genome annotation databases
GeneID	4189733.
GenomeReviews	Gene locus ECP_4113 in contig CP000247_GR.
KEGG	ecp:ECP_4113.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q0TAG0.
OMA	Q0TAG0. GSHEFYM.
Enzyme and pathway databases
BioCyc	ECOL362663:ECP_4113-MON.
Family and domain databases
HAMAP	MF_00541. [Tree]
InterPro	IPR009308. Rhamnose_isomerase. IPR013022. Xyl_isomerase-like_TIM-brl. [Graphical view]
Gene3D	G3DSA:3.20.20.150. Xyl_isomerase-like_TIM-brl. 1 hit.
Pfam	PF06134. RhaA. 1 hit. [Graphical view]
TIGRFAMs	TIGR01748. rhaA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

RHAA_ECOL5

Accession

Primary (citable) accession number: Q0TAG0

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	September 5, 2006
Last modified:	June 16, 2009
This is version 22 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)