Reviewed, UniProtKB/Swiss-Prot Q0TA86 (COAA_ECOL5)

Names and origin

Protein names

Recommended name:
    Pantothenate kinase
    EC=2.7.1.33
Alternative name(s):
    Pantothenic acid kinase

Gene names

Name:	coaA
Ordered Locus Names:	ECP_4188

Organism

Escherichia coli O6:K15:H31 (strain 536 / UPEC) [Complete proteome] [HAMAP]

Taxonomic identifier

362663 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia

Protein attributes

Sequence length	316 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	ATP + (R)-pantothenate = ADP + (R)-4'-phosphopantothenate. HAMAP MF_00215
Pathway	Cofactor biosynthesis; coenzyme A biosynthesis; coenzyme A from pantothenate: step 1/5. HAMAP MF_00215
Subcellular location	Cytoplasm Probable.
Sequence similarities	Belongs to the prokaryotic pantothenate kinase family.

Ontologies

Keywords
Biological process	Coenzyme A biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	coenzyme A biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP pantothenate kinase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 316	316	Pantothenate kinase HAMAP MF_00215		PRO_0000325554
Regions
	Nucleotide binding	95 – 102	8	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	Q0TA86-1 [UniParc]. Last modified March 18, 2008. Version 2. Checksum: DDDC1922C5C52A70	FASTA	316	36,360
	10 20 30 40 50 60 MSIKEQTLMT PYLQFDRNQW AALRDSVPMT LSEDEIARLK GINEDLSLEE VAEIYLPLSR 70 80 90 100 110 120 LLNFYISSNL RRQAVLEQFL GTNGQRIPYI ISIAGSVAVG KSTTARVLQA LLSRWPEHRR 130 140 150 160 170 180 VELITTDGFL HPNQVLKERG LMKKKGFPES YDMHRLVKFV SDLKSGVPNV TAPVYSHLIY 190 200 210 220 230 240 DVIPDGDKTV VQPDILILEG LNVLQSGMDY PHDPHHVFVS DFVDFSIYVD APEDLLQTWY 250 260 270 280 290 300 INRFLKFREG AFTDPDSYFH NYAKLTKEEA IKTAMTLWKE INWLNLKQNI LPTRERASLI 310 LTKSANHAVE EVRLRK

References

[1]

"Role of pathogenicity island-associated integrases in the genome plasticity of uropathogenic Escherichia coli strain 536." Hochhut B., Wilde C., Balling G., Middendorf B., Dobrindt U., Brzuszkiewicz E., Gottschalk G., Carniel E., Hacker J. Mol. Microbiol. 61:584-595(2006) [PubMed: 16879640] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000247 Genomic DNA. Translation: ABG72143.1. Different initiation.
RefSeq	YP_672044.1.
3D structure databases
SMR	Q0TA86. Positions 13-323.
ModBase	Search...
Genome annotation databases
GeneID	4189216.
GenomeReviews	Gene locus ECP_4188 in contig CP000247_GR.
KEGG	ecp:ECP_4188.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q0TA86.
Enzyme and pathway databases
BioCyc	ECOL362663:ECP_4188-MON.
Family and domain databases
HAMAP	MF_00215. [Tree]
InterPro	IPR004566. PanK_bact. IPR006083. PRK_URK. [Graphical view]
PANTHER	PTHR10285:SF7. PanK_bact. 1 hit.
Pfam	PF00485. PRK. 1 hit. [Graphical view]
PIRSF	PIRSF000545. Pantothenate_kin. 1 hit.
TIGRFAMs	TIGR00554. panK_bact. 1 hit.
ProtoNet	Search...

Entry information

Entry name

COAA_ECOL5

Accession

Primary (citable) accession number: Q0TA86

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 18, 2008
Last sequence update:	March 18, 2008
Last modified:	June 16, 2009
This is version 22 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)