Q0TA69 (NUDC_ECOL5) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
NADH pyrophosphatase
EC=3.6.1.22

Gene names

Name:	nudC
Ordered Locus Names:	ECP_4209

Organism

Escherichia coli O6:K15:H31 (strain 536 / UPEC) [Complete proteome] [HAMAP]

Taxonomic identifier

362663 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia

Protein attributes

Sequence length	257 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	NAD+ + H2O = AMP + NMN. HAMAP MF_00297
Cofactor	Divalent metal cations. Magnesium or manganese By similarity. Binds 1 zinc ion per subunit By similarity. HAMAP MF_00297
Subunit structure	Homodimer By similarity. HAMAP MF_00297
Sequence similarities	Belongs to the Nudix hydrolase family. NudC subfamily. Contains 1 nudix hydrolase domain.

Ontologies

Keywords
Ligand	Magnesium Manganese Metal-binding NAD Zinc
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	NAD+ diphosphatase activity Inferred from electronic annotation. Source: EC metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 257	257	NADH pyrophosphatase HAMAP MF_00297		PRO_1000021905
Regions
	Domain	125 – 248	124	Nudix hydrolase
	Motif	159 – 180	22	Nudix box HAMAP MF_00297
Sites
	Metal binding	98	1	Zinc By similarity
	Metal binding	101	1	Zinc By similarity
	Metal binding	116	1	Zinc By similarity
	Metal binding	119	1	Zinc By similarity
	Metal binding	174	1	Divalent metal cation By similarity
	Metal binding	178	1	Divalent metal cation By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q0TA69 [UniParc]. Last modified September 5, 2006. Version 1. Checksum: BC194BDD99B43F3E	FASTA	257	29,688
	10 20 30 40 50 60 MDRIIEKLDH GWWVVSHEQK LWLPKGELPY GEAANFDLVG QRALQIGEWQ GEPVWLVQLQ 70 80 90 100 110 120 RRHDMGSVRQ VIDLDVGLFQ LAGRGVQLAE FYRSHKYCGY CGHEMYPSKT EWAMLCSHCR 130 140 150 160 170 180 ERYYPQIAPC IIVAIRRDDS ILLAQHTRHR NGVHTVLAGF VEVGETLEQA VAREVMEESG 190 200 210 220 230 240 IKVKNLRYVT SQPWPFPQSL MTAFMAEYDS GEIVIDPKEL LEANWYRYDD LPLLPPPGTV 250 ARRLIEDTVA MCRAEYE

References

[1]

"Role of pathogenicity island-associated integrases in the genome plasticity of uropathogenic Escherichia coli strain 536." Hochhut B., Wilde C., Balling G., Middendorf B., Dobrindt U., Brzuszkiewicz E., Gottschalk G., Carniel E., Hacker J. Mol. Microbiol. 61:584-595(2006) [PubMed: 16879640] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 536 / UPEC.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000247 Genomic DNA. Translation: ABG72160.1.
RefSeq	YP_672061.1. NC_008253.1.
3D structure databases
ProteinModelPortal	Q0TA69.
SMR	Q0TA69. Positions 1-256.
ModBase	Search...
Protein-protein interaction databases
STRING	Q0TA69.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBESCT00000046276; EBESCP00000044465; EBESCG00000045326.
GeneID	4188681.
GenomeReviews	Gene locus ECP_4209 in contig CP000247_GR.
KEGG	ecp:ECP_4209.
PATRIC	18199341. VBIEscCol77757_4255.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG2816.
GeneTree	EBGT00050000011158.
HOGENOM	HBG736436.
OMA	PHSLMMG.
PhylomeDB	Q0TA69.
ProtClustDB	PRK00241.
Enzyme and pathway databases
BioCyc	ECOL362663:ECP_4209-MONOMER.
Family and domain databases
HAMAP	MF_00297. Nudix_NudC. [Tree]
InterPro	IPR015375. NADH_PPase-like_N. IPR022925. NADH_pyroPase_NudC. IPR020084. NUDIX_hydrolase_CS. IPR000086. NUDIX_hydrolase_dom. IPR015797. NUDIX_hydrolase_dom-like. IPR015376. Znr_NADH_PPase. [Graphical view]
Gene3D	G3DSA:3.90.79.10. NUDIX_hydrolase. 1 hit.
KO	K03426.
Pfam	PF00293. NUDIX. 1 hit. PF09296. NUDIX-like. 1 hit. PF09297. zf-NADH-PPase. 1 hit. [Graphical view]
SUPFAM	SSF55811. NUDIX_hydrolase. 2 hits.
PROSITE	PS51462. NUDIX. 1 hit. PS00893. NUDIX_BOX. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

NUDC_ECOL5

Accession

Primary (citable) accession number: Q0TA69

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	September 5, 2006
Last modified:	January 25, 2012
This is version 38 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program