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Protein
Submitted name:

Alpha-galactosidase

Gene

ECP_4362

Organism
Escherichia coli O6:K15:H31 (strain 536 / UPEC)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein inferred from homologyi

Functioni

Cofactori

NAD(+)UniRule annotationNote: Binds 1 NAD(+) per subunit.UniRule annotation

GO - Molecular functioni

  1. oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor Source: InterPro
  2. raffinose alpha-galactosidase activity Source: UniProtKB-EC

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

GlycosidaseUniRule annotationImported, Hydrolase

Keywords - Ligandi

NADUniRule annotation

Enzyme and pathway databases

BioCyciECOL362663:GIY5-4403-MONOMER.

Protein family/group databases

CAZyiGH4. Glycoside Hydrolase Family 4.

Names & Taxonomyi

Protein namesi
Submitted name:
Alpha-galactosidaseImported (EC:3.2.1.22Imported)
Gene namesi
Ordered Locus Names:ECP_4362Imported
OrganismiEscherichia coli O6:K15:H31 (strain 536 / UPEC)Imported
Taxonomic identifieri362663 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000009182 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi362663.ECP_4362.

Structurei

3D structure databases

ProteinModelPortaliQ0T9S3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 4 family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1486.
HOGENOMiHOG000239812.
KOiK07406.
OMAiTHEYASY.
OrthoDBiEOG6CP3SG.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
InterProiIPR019802. GlycHydrolase_4_CS.
IPR001088. Glyco_hydro_4.
IPR022616. Glyco_hydro_4_C.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF02056. Glyco_hydro_4. 1 hit.
PF11975. Glyco_hydro_4C. 1 hit.
[Graphical view]
PRINTSiPR00732. GLHYDRLASE4.
SUPFAMiSSF56327. SSF56327. 1 hit.
PROSITEiPS01324. GLYCOSYL_HYDROL_F4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q0T9S3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMSAPKITFI GAGSTIFVKN ILGDVFHREA LKTAHIALMD IDPTRLEESH
60 70 80 90 100
IVVRKLMDSA GASGKITCHT QQKEALQDAD FVVVAFQIGG YEPCTVTDFE
110 120 130 140 150
VCKRHGLEQT IADTLGPGGI MRALRTIPHL WQICEDMTEV CPDATMLNYV
160 170 180 190 200
NPMAMNTWAM YARYPHIKQV GLCHSVQGTA EELARDLNID PATLRYRCAG
210 220 230 240 250
INHMAFYLEL ERKTADGSYV NLYPELLAAY EAGQAPKPNI HGNTRCQNIV
260 270 280 290 300
RYEMFKKLGY FVTESSEHFA EYTPWFIKPG REDLIERYKV PLDEYPKRCV
310 320 330 340 350
EQLANWHKEL EEYKNASRID IKPSREYAST IMNAIWTGEP SVIYGNVRND
360 370 380 390 400
GLIDNLPQGC CVEVACLVDA NGIQPTKAGT LPSHLAALMQ TNINVQTLLT
410 420 430 440 450
EAILTENRDR VYHAAMMDPH TAAVLGIDEI YALVDDLIAA HGDWLPGWLH

R
Length:451
Mass (Da):50,614
Last modified:September 5, 2006 - v1
Checksum:i30151EE2167D27E7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000247 Genomic DNA. Translation: ABG72306.1.
RefSeqiYP_672207.1. NC_008253.1.

Genome annotation databases

EnsemblBacteriaiABG72306; ABG72306; ECP_4362.
KEGGiecp:ECP_4362.
PATRICi18199663. VBIEscCol77757_4412.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000247 Genomic DNA. Translation: ABG72306.1.
RefSeqiYP_672207.1. NC_008253.1.

3D structure databases

ProteinModelPortaliQ0T9S3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi362663.ECP_4362.

Protein family/group databases

CAZyiGH4. Glycoside Hydrolase Family 4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABG72306; ABG72306; ECP_4362.
KEGGiecp:ECP_4362.
PATRICi18199663. VBIEscCol77757_4412.

Phylogenomic databases

eggNOGiCOG1486.
HOGENOMiHOG000239812.
KOiK07406.
OMAiTHEYASY.
OrthoDBiEOG6CP3SG.

Enzyme and pathway databases

BioCyciECOL362663:GIY5-4403-MONOMER.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
InterProiIPR019802. GlycHydrolase_4_CS.
IPR001088. Glyco_hydro_4.
IPR022616. Glyco_hydro_4_C.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF02056. Glyco_hydro_4. 1 hit.
PF11975. Glyco_hydro_4C. 1 hit.
[Graphical view]
PRINTSiPR00732. GLHYDRLASE4.
SUPFAMiSSF56327. SSF56327. 1 hit.
PROSITEiPS01324. GLYCOSYL_HYDROL_F4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Role of pathogenicity island-associated integrases in the genome plasticity of uropathogenic Escherichia coli strain 536."
    Hochhut B., Wilde C., Balling G., Middendorf B., Dobrindt U., Brzuszkiewicz E., Gottschalk G., Carniel E., Hacker J.
    Mol. Microbiol. 61:584-595(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 536 / UPECImported.

Entry informationi

Entry nameiQ0T9S3_ECOL5
AccessioniPrimary (citable) accession number: Q0T9S3
Entry historyi
Integrated into UniProtKB/TrEMBL: September 5, 2006
Last sequence update: September 5, 2006
Last modified: April 1, 2015
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.