ID   ULAE_ECOL5              Reviewed;         284 AA.
AC   Q0T9J6;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 1.
DT   16-JUN-2009, entry version 24.
DE   RecName: Full=L-ribulose-5-phosphate 3-epimerase ulaE;
DE            EC=5.1.3.22;
DE   AltName: Full=L-xylulose-5-phosphate 3-epimerase;
DE   AltName: Full=L-ascorbate utilization protein E;
GN   Name=ulaE; OrderedLocusNames=ECP_4442;
OS   Escherichia coli O6:K15:H31 (strain 536 / UPEC).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=362663;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16879640; DOI=10.1111/j.1365-2958.2006.05255.x;
RA   Hochhut B., Wilde C., Balling G., Middendorf B., Dobrindt U.,
RA   Brzuszkiewicz E., Gottschalk G., Carniel E., Hacker J.;
RT   "Role of pathogenicity island-associated integrases in the genome
RT   plasticity of uropathogenic Escherichia coli strain 536.";
RL   Mol. Microbiol. 61:584-595(2006).
CC   -!- FUNCTION: Catalyzes the isomerization of L-xylulose-5-phosphate to
CC       L-ribulose-5-phosphate. Is involved in the anaerobic L-ascorbate
CC       utilization (By similarity).
CC   -!- CATALYTIC ACTIVITY: L-ribulose 5-phosphate = L-xylulose 5-
CC       phosphate.
CC   -!- PATHWAY: Cofactor degradation; L-ascorbic acid degradation; D-
CC       xylulose 5-phosphate from L-ascorbic acid: step 3/4.
CC   -!- INDUCTION: Induced by L-ascorbate. Repressed by ulaR (By
CC       similarity).
CC   -!- SIMILARITY: Belongs to the HUMPI family.
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DR   EMBL; CP000247; ABG72383.1; -; Genomic_DNA.
DR   RefSeq; YP_672284.1; -.
DR   GeneID; 4190034; -.
DR   GenomeReviews; CP000247_GR; ECP_4442.
DR   KEGG; ecp:ECP_4442; -.
DR   HOGENOM; Q0T9J6; -.
DR   OMA; Q0T9J6; VVKARDW.
DR   BioCyc; ECOL362663:ECP_4442-MON; -.
DR   GO; GO:0016861; F:intramolecular oxidoreductase activity, int...; IEA:InterPro.
DR   GO; GO:0034015; F:L-ribulose-5-phosphate 3-epimerase activity; IEA:HAMAP.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR   GO; GO:0019852; P:L-ascorbic acid metabolic process; IEA:HAMAP.
DR   HAMAP; MF_01951; -; 1.
DR   InterPro; IPR004560; Hxl6Piso_put.
DR   InterPro; IPR013022; Xyl_isomerase-like_TIM-brl.
DR   InterPro; IPR012307; Xyl_isomerase-typ_TIM-brl.
DR   Gene3D; G3DSA:3.20.20.150; Xyl_isomerase-like_TIM-brl; 1.
DR   Pfam; PF01261; AP_endonuc_2; 1.
DR   TIGRFAMs; TIGR00542; hxl6Piso_put; 1.
PE   2: Evidence at transcript level;
KW   Complete proteome; Isomerase.
FT   CHAIN         1    284       L-ribulose-5-phosphate 3-epimerase ulaE.
FT                                /FTId=PRO_1000070633.
SQ   SEQUENCE   284 AA;  32035 MW;  31CA9644DC4A8529 CRC64;
     MLSKQIPLGI YEKALPAGEC WLERLQLAKT LGFDFVEMSV DETDDRLSRL DWSREQRLAL
     VNAIVETGVR VPSMCLSAHR RFPLGSEDDA VRAQGLEIMR KAIQFAQDVG IRVIQLAGYD
     VYYQEANNET RRRFRDGLKE SVEMASRAQV TLAMEIMDYP LMNSISKALG YAHYLNNPWF
     QLYPDIGNLS AWDNDVQMEL QAGIGHIVAV HVKDTKPGVF KNVPFGEGVV DFERCFETLK
     QSGYCGPYLI EMWSETAEDP AAEVAKARDW VKARMAKAGM VEAA
//