Reviewed, UniProtKB/Swiss-Prot Q0T9J6 (ULAE_ECOL5)

Names and origin

Protein names

Recommended name:
    L-ribulose-5-phosphate 3-epimerase ulaE
    EC=5.1.3.22
Alternative name(s):
    L-xylulose-5-phosphate 3-epimerase
    L-ascorbate utilization protein E

Gene names

Name:	ulaE
Ordered Locus Names:	ECP_4442

Organism

Escherichia coli O6:K15:H31 (strain 536 / UPEC) [Complete proteome] [HAMAP]

Taxonomic identifier

362663 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia

Protein attributes

Sequence length	284 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Catalyzes the isomerization of L-xylulose-5-phosphate to L-ribulose-5-phosphate. Is involved in the anaerobic L-ascorbate utilization By similarity.
Catalytic activity	L-ribulose 5-phosphate = L-xylulose 5-phosphate. HAMAP MF_01951
Pathway	Cofactor degradation; L-ascorbic acid degradation; D-xylulose 5-phosphate from L-ascorbic acid: step 3/4. HAMAP MF_01951
Induction	Induced by L-ascorbate. Repressed by ulaR By similarity.
Sequence similarities	Belongs to the HUMPI family.

Ontologies

Keywords
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	L-ascorbic acid metabolic process Inferred from electronic annotation. Source: HAMAP carbohydrate metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	L-ribulose-5-phosphate 3-epimerase activity Inferred from electronic annotation. Source: HAMAP intramolecular oxidoreductase activity, interconverting aldoses and ketoses Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 284	284	L-ribulose-5-phosphate 3-epimerase ulaE HAMAP MF_01951		PRO_1000070633

Sequences

	Sequence		Length	Mass (Da)
	Q0T9J6-1 [UniParc]. Last modified September 5, 2006. Version 1. Checksum: 31CA9644DC4A8529	FASTA	284	32,035
	10 20 30 40 50 60 MLSKQIPLGI YEKALPAGEC WLERLQLAKT LGFDFVEMSV DETDDRLSRL DWSREQRLAL 70 80 90 100 110 120 VNAIVETGVR VPSMCLSAHR RFPLGSEDDA VRAQGLEIMR KAIQFAQDVG IRVIQLAGYD 130 140 150 160 170 180 VYYQEANNET RRRFRDGLKE SVEMASRAQV TLAMEIMDYP LMNSISKALG YAHYLNNPWF 190 200 210 220 230 240 QLYPDIGNLS AWDNDVQMEL QAGIGHIVAV HVKDTKPGVF KNVPFGEGVV DFERCFETLK 250 260 270 280 QSGYCGPYLI EMWSETAEDP AAEVAKARDW VKARMAKAGM VEAA

References

[1]

"Role of pathogenicity island-associated integrases in the genome plasticity of uropathogenic Escherichia coli strain 536." Hochhut B., Wilde C., Balling G., Middendorf B., Dobrindt U., Brzuszkiewicz E., Gottschalk G., Carniel E., Hacker J. Mol. Microbiol. 61:584-595(2006) [PubMed: 16879640] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000247 Genomic DNA. Translation: ABG72383.1.
RefSeq	YP_672284.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	4190034.
GenomeReviews	Gene locus ECP_4442 in contig CP000247_GR.
KEGG	ecp:ECP_4442.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q0T9J6.
OMA	Q0T9J6. VVKARDW.
Enzyme and pathway databases
BioCyc	ECOL362663:ECP_4442-MON.
Family and domain databases
HAMAP	MF_01951. [Tree]
InterPro	IPR004560. Hxl6Piso_put. IPR013022. Xyl_isomerase-like_TIM-brl. IPR012307. Xyl_isomerase-typ_TIM-brl. [Graphical view]
Gene3D	G3DSA:3.20.20.150. Xyl_isomerase-like_TIM-brl. 1 hit.
Pfam	PF01261. AP_endonuc_2. 1 hit. [Graphical view]
TIGRFAMs	TIGR00542. hxl6Piso_put. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ULAE_ECOL5

Accession

Primary (citable) accession number: Q0T9J6

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	September 5, 2006
Last modified:	June 16, 2009
This is version 24 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)