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Q0T5R7

- NAGK_SHIF8

UniProt

Q0T5R7 - NAGK_SHIF8

Protein

N-acetyl-D-glucosamine kinase

Gene

nagK

Organism
Shigella flexneri serotype 5b (strain 8401)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 53 (01 Oct 2014)
      Sequence version 1 (05 Sep 2006)
      Previous versions | rss
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    Functioni

    Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P.UniRule annotation

    Catalytic activityi

    ATP + N-acetyl-D-glucosamine = ADP + N-acetyl-D-glucosamine 6-phosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi157 – 1571ZincUniRule annotation
    Metal bindingi177 – 1771ZincUniRule annotation
    Metal bindingi179 – 1791ZincUniRule annotation
    Metal bindingi184 – 1841ZincUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi4 – 118ATPUniRule annotation
    Nucleotide bindingi133 – 1408ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. N-acetylglucosamine kinase activity Source: UniProtKB-HAMAP
    3. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. N-acetylglucosamine metabolic process Source: UniProtKB-HAMAP
    2. peptidoglycan turnover Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Carbohydrate metabolism

    Keywords - Ligandi

    ATP-binding, Metal-binding, Nucleotide-binding, Zinc

    Enzyme and pathway databases

    BioCyciSFLE373384:GHZM-1138-MONOMER.
    UniPathwayiUPA00544.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    N-acetyl-D-glucosamine kinaseUniRule annotation (EC:2.7.1.59UniRule annotation)
    Alternative name(s):
    GlcNAc kinaseUniRule annotation
    Gene namesi
    Name:nagKUniRule annotation
    Ordered Locus Names:SFV_1139
    OrganismiShigella flexneri serotype 5b (strain 8401)
    Taxonomic identifieri373384 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeShigella
    ProteomesiUP000000659: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 303303N-acetyl-D-glucosamine kinasePRO_0000301942Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi373384.SFV_1139.

    Structurei

    3D structure databases

    ProteinModelPortaliQ0T5R7.
    SMRiQ0T5R7. Positions 1-303.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ROK (NagC/XylR) family. NagK subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1940.
    HOGENOMiHOG000150087.
    KOiK00884.
    OMAiPEIVAQW.
    OrthoDBiEOG61P6P0.

    Family and domain databases

    HAMAPiMF_01271. GlcNAc_kinase.
    InterProiIPR023505. N-acetyl-D-glucosamine_kinase.
    IPR000600. ROK.
    [Graphical view]
    PfamiPF00480. ROK. 1 hit.
    [Graphical view]
    PROSITEiPS01125. ROK. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q0T5R7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MYYGFDIGGT KIALGVFDSG RQLQWEKRVP TPRDSYDAFL DAVCELVAEA    50
    DQRFGCKGSV GIGIPGMPET EDGKLYAANV PAASGKPLRA DLSARLDRDV 100
    RLDNDANCFA LSEAWDDEFT QYPLVMGLIL GTGVGGGLVF NGKPITGKSY 150
    ITGEFGHMRL PVDALTMMGL DFPLRRCGCG QHGCIENYLS GRGFAWLYQH 200
    YYHQPLQAPE IIALYDQGDE QARAHVERYL DLLAVSLGNI LTIVDPDLVV 250
    IGGGLSNFPA ITTQLADRLP CHLLPVARVP RIERARHGDA GGMRGAAFLH 300
    LTD 303
    Length:303
    Mass (Da):32,987
    Last modified:September 5, 2006 - v1
    Checksum:i65572B2CCFEBFBA5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000266 Genomic DNA. Translation: ABF03348.1.
    RefSeqiYP_688653.1. NC_008258.1.

    Genome annotation databases

    EnsemblBacteriaiABF03348; ABF03348; SFV_1139.
    GeneIDi4208953.
    KEGGisfv:SFV_1139.
    PATRICi18725558. VBIShiFle33408_1303.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000266 Genomic DNA. Translation: ABF03348.1 .
    RefSeqi YP_688653.1. NC_008258.1.

    3D structure databases

    ProteinModelPortali Q0T5R7.
    SMRi Q0T5R7. Positions 1-303.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 373384.SFV_1139.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABF03348 ; ABF03348 ; SFV_1139 .
    GeneIDi 4208953.
    KEGGi sfv:SFV_1139.
    PATRICi 18725558. VBIShiFle33408_1303.

    Phylogenomic databases

    eggNOGi COG1940.
    HOGENOMi HOG000150087.
    KOi K00884.
    OMAi PEIVAQW.
    OrthoDBi EOG61P6P0.

    Enzyme and pathway databases

    UniPathwayi UPA00544 .
    BioCyci SFLE373384:GHZM-1138-MONOMER.

    Family and domain databases

    HAMAPi MF_01271. GlcNAc_kinase.
    InterProi IPR023505. N-acetyl-D-glucosamine_kinase.
    IPR000600. ROK.
    [Graphical view ]
    Pfami PF00480. ROK. 1 hit.
    [Graphical view ]
    PROSITEi PS01125. ROK. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of Shigella flexneri 5b and comparison with Shigella flexneri 2a."
      Nie H., Yang F., Zhang X., Yang J., Chen L., Wang J., Xiong Z., Peng J., Sun L., Dong J., Xue Y., Xu X., Chen S., Yao Z., Shen Y., Jin Q.
      BMC Genomics 7:173-173(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 8401.

    Entry informationi

    Entry nameiNAGK_SHIF8
    AccessioniPrimary (citable) accession number: Q0T5R7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 11, 2007
    Last sequence update: September 5, 2006
    Last modified: October 1, 2014
    This is version 53 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3