Reviewed,
UniProtKB/Swiss-Prot Q0T4V3 (ASTD_SHIF8)
Last modified
June 16, 2009.
Version 26.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: N-succinylglutamate 5-semialdehyde dehydrogenase EC=1.2.1.71 Alternative name(s): Succinylglutamic semialdehyde dehydrogenase Short name=SGSD | ||||
| Gene names |
| ||||
| Organism | Shigella flexneri serotype 5b (strain 8401) [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 373384 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Shigella |
Protein attributes
| Sequence length | 492 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | Catalyzes the NAD-dependent reduction of succinylglutamate semialdehyde into succinylglutamate By similarity. |
| Catalytic activity | N-succinyl-L-glutamate 5-semialdehyde + NAD+ + H2O = N-succinyl-L-glutamate + NADH. HAMAP MF_01174 |
| Pathway | Amino-acid degradation; L-arginine degradation via AST pathway; L-glutamate and succinate from L-arginine: step 4/5. HAMAP MF_01174 |
| Sequence similarities | Belongs to the aldehyde dehydrogenase family. AstD subfamily. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Arginine metabolism |
| Ligand | NAD |
| Molecular function | Oxidoreductase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | arginine catabolic process to glutamate Inferred from electronic annotation. Source: HAMAP oxidation reductionInferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | succinylglutamate-semialdehyde dehydrogenase activity Inferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 492 | 492 | N-succinylglutamate 5-semialdehyde dehydrogenase HAMAP MF_01174 | PRO_1000065769 | |||||
Regions | |||||||||
| Nucleotide binding | 220 – 225 | 6 | NAD By similarity | ||||||
Sites | |||||||||
| Active site | 243 | 1 | By similarity | ||||||
| Active site | 277 | 1 | By similarity | ||||||
Sequences
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References
| [1] | "Complete genome sequence of Shigella flexneri 5b and comparison with Shigella flexneri 2a." Nie H., Yang F., Zhang X., Yang J., Chen L., Wang J., Xiong Z., Peng J., Sun L., Dong J., Xue Y., Xu X., Chen S., Yao Z., Shen Y., Jin Q. BMC Genomics 7:173-173(2006) [PubMed: 16822325] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
Cross-references
Sequence databases | |
|---|---|
| CP000266 Genomic DNA. Translation: ABF03662.1. | |
| RefSeq | YP_688967.1. |
3D structure databases | |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 4208100. |
| GenomeReviews | Gene locus SFV_1474 in contig CP000266_GR. |
| KEGG | sfv:SFV_1474. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | Q0T4V3. |
| OMA | Q0T4V3. KAYHART. |
Enzyme and pathway databases | |
| BioCyc | SFLE373384:SFV_1474-MON. |
Family and domain databases | |
| HAMAP | MF_01174. [Tree] |
| InterPro | IPR016160. Ald_DH_CS. IPR016162. Ald_DH_N. IPR015590. Aldehyde_DH. IPR017649. SuccinylGlu_semiald_DH_AstD. [Graphical view] |
| Gene3D | G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit. |
| PANTHER | PTHR11699. Aldehyde_dehyd. 1 hit. |
| Pfam | PF00171. Aldedh. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR03240. arg_catab_astD. 1 hit. |
| PROSITE | PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit. PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | ASTD_SHIF8 | ||||||||
| Accession | Primary (citable) accession number: Q0T4V3 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


