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Q0T4H1

- FOLM_SHIF8

UniProt

Q0T4H1 - FOLM_SHIF8

Protein

Dihydrofolate reductase FolM

Gene

folM

Organism
Shigella flexneri serotype 5b (strain 8401)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 54 (01 Oct 2014)
      Sequence version 1 (05 Sep 2006)
      Previous versions | rss
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    Functioni

    Catalyzes the reduction of dihydrofolate to tetrahydrofolate.By similarity

    Catalytic activityi

    5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei152 – 1521Proton acceptorPROSITE-ProRule annotation

    GO - Molecular functioni

    1. dihydrofolate reductase activity Source: UniProtKB-EC

    GO - Biological processi

    1. one-carbon metabolic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    One-carbon metabolism

    Keywords - Ligandi

    NADP

    Enzyme and pathway databases

    BioCyciSFLE373384:GHZM-1618-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Dihydrofolate reductase FolM (EC:1.5.1.3)
    Short name:
    DHFR
    Gene namesi
    Name:folM
    Ordered Locus Names:SFV_1621
    OrganismiShigella flexneri serotype 5b (strain 8401)
    Taxonomic identifieri373384 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeShigella
    ProteomesiUP000000659: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 240240Dihydrofolate reductase FolMPRO_0000339402Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi373384.SFV_1621.

    Structurei

    3D structure databases

    ProteinModelPortaliQ0T4H1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG1028.
    KOiK13938.
    OMAiMKIAPGE.
    OrthoDBiEOG6WDSG3.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    InterProiIPR002198. DH_sc/Rdtase_SDR.
    IPR002347. Glc/ribitol_DH.
    IPR016040. NAD(P)-bd_dom.
    IPR020904. Sc_DH/Rdtase_CS.
    [Graphical view]
    PfamiPF00106. adh_short. 1 hit.
    [Graphical view]
    PRINTSiPR00081. GDHRDH.
    PROSITEiPS00061. ADH_SHORT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q0T4H1-1 [UniParc]FASTAAdd to Basket

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    MGKTQPLPIL ITGGGRRIGL ALAWHFINQK QPVIVSYRTH YPAIDGLINA    50
    GAQCIQADFS TNDGVMAFAD EVLKTTHGLR AILHNASAWI AEKPGAPLAD 100
    VLACMMQIHV NTPYLLNHAL ERLLRGHGHA ASDIIHFTDY VVERGSDKHV 150
    AYAASKAALD NMTRSFARKL APEVKVNSIA PSLILFNEHD DAEYRQQALN 200
    KSLMKTAPGE KEVIDLVDYL LTSCFVTGRS FPLDGGRHLR 240
    Length:240
    Mass (Da):26,330
    Last modified:September 5, 2006 - v1
    Checksum:i1A227307B826086A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000266 Genomic DNA. Translation: ABF03794.1.
    RefSeqiYP_689099.1. NC_008258.1.

    Genome annotation databases

    EnsemblBacteriaiABF03794; ABF03794; SFV_1621.
    GeneIDi4210787.
    KEGGisfv:SFV_1621.
    PATRICi18726720. VBIShiFle33408_1873.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000266 Genomic DNA. Translation: ABF03794.1 .
    RefSeqi YP_689099.1. NC_008258.1.

    3D structure databases

    ProteinModelPortali Q0T4H1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 373384.SFV_1621.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABF03794 ; ABF03794 ; SFV_1621 .
    GeneIDi 4210787.
    KEGGi sfv:SFV_1621.
    PATRICi 18726720. VBIShiFle33408_1873.

    Phylogenomic databases

    eggNOGi COG1028.
    KOi K13938.
    OMAi MKIAPGE.
    OrthoDBi EOG6WDSG3.

    Enzyme and pathway databases

    BioCyci SFLE373384:GHZM-1618-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    InterProi IPR002198. DH_sc/Rdtase_SDR.
    IPR002347. Glc/ribitol_DH.
    IPR016040. NAD(P)-bd_dom.
    IPR020904. Sc_DH/Rdtase_CS.
    [Graphical view ]
    Pfami PF00106. adh_short. 1 hit.
    [Graphical view ]
    PRINTSi PR00081. GDHRDH.
    PROSITEi PS00061. ADH_SHORT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of Shigella flexneri 5b and comparison with Shigella flexneri 2a."
      Nie H., Yang F., Zhang X., Yang J., Chen L., Wang J., Xiong Z., Peng J., Sun L., Dong J., Xue Y., Xu X., Chen S., Yao Z., Shen Y., Jin Q.
      BMC Genomics 7:173-173(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 8401.

    Entry informationi

    Entry nameiFOLM_SHIF8
    AccessioniPrimary (citable) accession number: Q0T4H1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 10, 2008
    Last sequence update: September 5, 2006
    Last modified: October 1, 2014
    This is version 54 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3