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Q0T2B1

- GLK_SHIF8

UniProt

Q0T2B1 - GLK_SHIF8

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Protein
Glucokinase
Gene
glk, SFV_2446
Organism
Shigella flexneri serotype 5b (strain 8401)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + D-glucose = ADP + D-glucose 6-phosphate.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi8 – 136ATP Reviewed prediction

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. glucokinase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. glycolytic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSFLE373384:GHZM-2442-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucokinase (EC:2.7.1.2)
Alternative name(s):
Glucose kinase
Gene namesi
Name:glk
Ordered Locus Names:SFV_2446
OrganismiShigella flexneri serotype 5b (strain 8401)
Taxonomic identifieri373384 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeShigella
ProteomesiUP000000659: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 321321GlucokinaseUniRule annotation
PRO_1000050976Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi373384.SFV_2446.

Structurei

3D structure databases

ProteinModelPortaliQ0T2B1.
SMRiQ0T2B1. Positions 2-321.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0837.
HOGENOMiHOG000274469.
KOiK00845.
OMAiDWVEMTN.
OrthoDBiEOG64BQ47.

Family and domain databases

HAMAPiMF_00524. Glucokinase.
InterProiIPR003836. Glucokinase.
[Graphical view]
PfamiPF02685. Glucokinase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00749. glk. 1 hit.

Sequencei

Sequence statusi: Complete.

Q0T2B1-1 [UniParc]FASTAAdd to Basket

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MTKYALVGDV GGTNARLALC DIASGEISQA KTYSGLDYPS LEAVIRVYLE    50
EHKVEVKDGC IAIACPITGD WVAMTNHTWA FSIAEMKKNL GFSHLEIIND 100
FTAVSMAIPM LKKEHLIQFG GAEPVEGKPI AVYGAGTGLG VAHLVHVDKR 150
WVSLPGEGGH VDFAPNSEEE AIILEILRAE IGHVSAERVL SGPGLVNLYR 200
AIVKADNRLP ENLKPKDITE RALADSCTDC RRALSLFCVI MGRFGGNLAL 250
NLGTFGGVFI AGGIVPRFLE FFKASGFRAA FEDKGRFKEY VHDIPVYLIV 300
HDYPGLLGSG AHLRQTLGHI L 321
Length:321
Mass (Da):34,772
Last modified:September 5, 2006 - v1
Checksum:i2D6CC1E1341A3823
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000266 Genomic DNA. Translation: ABF04554.1.
RefSeqiYP_689859.1. NC_008258.1.

Genome annotation databases

EnsemblBacteriaiABF04554; ABF04554; SFV_2446.
GeneIDi4208644.
KEGGisfv:SFV_2446.
PATRICi18728660. VBIShiFle33408_2820.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000266 Genomic DNA. Translation: ABF04554.1 .
RefSeqi YP_689859.1. NC_008258.1.

3D structure databases

ProteinModelPortali Q0T2B1.
SMRi Q0T2B1. Positions 2-321.
ModBasei Search...

Protein-protein interaction databases

STRINGi 373384.SFV_2446.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABF04554 ; ABF04554 ; SFV_2446 .
GeneIDi 4208644.
KEGGi sfv:SFV_2446.
PATRICi 18728660. VBIShiFle33408_2820.

Phylogenomic databases

eggNOGi COG0837.
HOGENOMi HOG000274469.
KOi K00845.
OMAi DWVEMTN.
OrthoDBi EOG64BQ47.

Enzyme and pathway databases

BioCyci SFLE373384:GHZM-2442-MONOMER.

Family and domain databases

HAMAPi MF_00524. Glucokinase.
InterProi IPR003836. Glucokinase.
[Graphical view ]
Pfami PF02685. Glucokinase. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00749. glk. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of Shigella flexneri 5b and comparison with Shigella flexneri 2a."
    Nie H., Yang F., Zhang X., Yang J., Chen L., Wang J., Xiong Z., Peng J., Sun L., Dong J., Xue Y., Xu X., Chen S., Yao Z., Shen Y., Jin Q.
    BMC Genomics 7:173-173(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 8401.

Entry informationi

Entry nameiGLK_SHIF8
AccessioniPrimary (citable) accession number: Q0T2B1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: September 5, 2006
Last modified: June 11, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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