Reviewed,
UniProtKB/Swiss-Prot Q0T1I7 (CYSI_SHIF8)
Last modified
November 25, 2008.
Version 20.
History...
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90%,
50% identity |
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Sulfite reductase [NADPH] hemoprotein beta-component Short name=SIR-HP Short name=SIRHP EC=1.8.1.2 | ||||
| Gene names |
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| Organism | Shigella flexneri serotype 5b (strain 8401) [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 373384 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Shigella |
Protein attributes
| Sequence length | 570 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | This enzyme catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate By similarity. |
| Catalytic activity | H(2)S + 3 NADP(+) + 3 H(2)O = sulfite + 3 NADPH. |
| Cofactor | Binds 1 siroheme per subunit By similarity. Binds 1 4Fe-4S cluster per subunit By similarity. |
| Subunit structure | Alpha(8)-beta(4). The alpha component is a flavoprotein, the beta component is a hemoprotein By similarity. |
| Sequence similarities | Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. |
Ontologies
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 570 | 570 | Sulfite reductase [NADPH] hemoprotein beta-component | PRO_1000068777 | |||||
Sites | |||||||||
| Metal binding | 434 | 1 | Iron-sulfur (4Fe-4S) By similarity | ||||||
| Metal binding | 440 | 1 | Iron-sulfur (4Fe-4S) By similarity | ||||||
| Metal binding | 479 | 1 | Iron-sulfur (4Fe-4S) By similarity | ||||||
| Metal binding | 483 | 1 | Iron (siroheme axial ligand) By similarity | ||||||
| Metal binding | 483 | 1 | Iron-sulfur (4Fe-4S) By similarity | ||||||
Sequences
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References
| [1] | "Complete genome sequence of Shigella flexneri 5b and comparison with Shigella flexneri 2a." Nie H., Yang F., Zhang X., Yang J., Chen L., Wang J., Xiong Z., Peng J., Sun L., Dong J., Xue Y., Xu X., Chen S., Yao Z., Shen Y., Jin Q. BMC Genomics 7:173-173(2006) [PubMed: 16822325] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
Cross-references
Sequence databases | |
|---|---|
| CP000266 Genomic DNA. Translation: ABF04828.1. | |
| RefSeq | YP_690133.1. |
3D structure databases | |
| SMR | Q0T1I7. Positions 81-570. |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 4210392. |
| GenomeReviews | Gene locus SFV_2742 in contig CP000266_GR. |
| KEGG | sfv:SFV_2742. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | Q0T1I7. |
Enzyme and pathway databases | |
| BioCyc | SFLE373384:SFV_2742-MON. |
Family and domain databases | |
| HAMAP | MF_01540. [Tree] |
| InterPro | IPR011786. CysI. IPR006066. Nir_Si_BS. IPR006067. Nir_Sir_4Fe4S. IPR005117. NiRdtase/SiRdtase_haem-b_fer. [Graphical view] |
| Pfam | PF01077. NIR_SIR. 1 hit. PF03460. NIR_SIR_ferr. 2 hits. [Graphical view] |
| PRINTS | PR00397. SIROHAEM. |
| TIGRFAMs | TIGR02041. CysI. 1 hit. |
| PROSITE | PS00365. NIR_SIR. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | CYSI_SHIF8 | ||||||||
| Accession | Primary (citable) accession number: Q0T1I7 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||

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