ID   FUCI_SHIF8              Reviewed;         591 AA.
AC   Q0T157;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 1.
DT   16-JUN-2009, entry version 23.
DE   RecName: Full=L-fucose isomerase;
DE            EC=5.3.1.25;
DE   AltName: Full=6-deoxy-L-galactose isomerase;
DE   AltName: Full=FucIase;
GN   Name=fucI; OrderedLocusNames=SFV_2881;
OS   Shigella flexneri serotype 5b (strain 8401).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales;
OC   Enterobacteriaceae; Shigella.
OX   NCBI_TaxID=373384;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16822325; DOI=10.1186/1471-2164-7-173;
RA   Nie H., Yang F., Zhang X., Yang J., Chen L., Wang J., Xiong Z.,
RA   Peng J., Sun L., Dong J., Xue Y., Xu X., Chen S., Yao Z., Shen Y.,
RA   Jin Q.;
RT   "Complete genome sequence of Shigella flexneri 5b and comparison with
RT   Shigella flexneri 2a.";
RL   BMC Genomics 7:173-173(2006).
CC   -!- FUNCTION: Converts the aldose L-fucose into the corresponding
CC       ketose L-fuculose (By similarity).
CC   -!- CATALYTIC ACTIVITY: L-fucose = L-fuculose.
CC   -!- COFACTOR: Manganese (By similarity).
CC   -!- PATHWAY: Carbohydrate degradation; L-fucose degradation; L-
CC       lactaldehyde and glycerone phosphate from L-fucose: step 1/3.
CC   -!- SUBUNIT: Homohexamer (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the L-fucose isomerase family.
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DR   EMBL; CP000266; ABF04958.1; -; Genomic_DNA.
DR   RefSeq; YP_690263.1; -.
DR   SMR; Q0T157; 1-591.
DR   GeneID; 4210301; -.
DR   GenomeReviews; CP000266_GR; SFV_2881.
DR   KEGG; sfv:SFV_2881; -.
DR   HOGENOM; Q0T157; -.
DR   OMA; Q0T157; TWFVPRL.
DR   BioCyc; SFLE373384:SFV_2881-MON; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0008736; F:L-fucose isomerase activity; IEA:HAMAP.
DR   GO; GO:0030145; F:manganese ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0019317; P:fucose catabolic process; IEA:InterPro.
DR   HAMAP; MF_01254; -; 1.
DR   InterPro; IPR015888; Fuc_isomerase-like_C.
DR   InterPro; IPR004216; Fuc_isomerase_C.
DR   InterPro; IPR012888; Fucose_iso_N1.
DR   InterPro; IPR005763; Fucose_isomerase.
DR   InterPro; IPR012889; Fucose_isomerase_N2.
DR   Gene3D; G3DSA:3.20.14.10; Fuc_isomerase_C; 1.
DR   Gene3D; G3DSA:3.40.50.1070; Fucose_iso_N1; 1.
DR   Gene3D; G3DSA:3.40.275.10; Fucose_iso_N2; 1.
DR   Pfam; PF02952; Fucose_iso_C; 1.
DR   Pfam; PF07881; Fucose_iso_N1; 1.
DR   Pfam; PF07882; Fucose_iso_N2; 1.
DR   TIGRFAMs; TIGR01089; fucI; 1.
PE   3: Inferred from homology;
KW   Carbohydrate metabolism; Complete proteome; Cytoplasm;
KW   Fucose metabolism; Isomerase; Manganese; Metal-binding.
FT   CHAIN         1    591       L-fucose isomerase.
FT                                /FTId=PRO_1000067226.
FT   ACT_SITE    337    337       Proton acceptor (By similarity).
FT   ACT_SITE    361    361       Proton acceptor (By similarity).
FT   METAL       337    337       Manganese (By similarity).
FT   METAL       361    361       Manganese (By similarity).
FT   METAL       528    528       Manganese (By similarity).
SQ   SEQUENCE   591 AA;  64977 MW;  E6245DEEDF34EF9B CRC64;
     MKKISLPKIG IRPVIDGRRM GVRESLEEQT MNMAKATAAL LTEKLRHACG AAVECVISDT
     CIAGMAEAAA CEEKFSSQNV GLTITVTPCW CYGSETIDMD PTRPKAIWGF NGTERPGAVY
     LAAALAAHSQ KGIPAFSIYG HDVQDADDTS IPADVEEKLL RFARAGLAVA SMKGKSYLSL
     GGVSMGIAGS IVDHNFFESW LGMKVQAVDM TELRRRIDQK IYDEAELEMA LAWADKNFRY
     GEDENNKQYQ RNAEQSRAVL RESLLMAMCI RDMMQGNSKL ADIGRVEESL GYNAIAAGFQ
     GQRHWTDQYP NGDTAEAILN SSFDWNGVRE PFVVATENDS LNGVAMLMGH QLTGTAQVFA
     DVRTYWSPEA IERVTGHKLD GLAEHGIIHL INSGSAALDG SCKQRDSEGN PTMKPHWEIS
     QQEADACLAA TEWCPAIHEY FRGGGYSSRF LTEGGVPFTM TRVNIIKGLG PVLQIAEGWS
     VELPKDVHDI LNKRTNSTWP TTWFAPRLTG KGPFTDVYSV MANWGANHGV LTIGHVGADF
     ITLASMLRIP VCMHNVEETK VYRPSAWAAH GMDIEGQDYR ACQNYGPLYK R
//