Reviewed, UniProtKB/Swiss-Prot Q0T0H6 (UXAC_SHIF8)

Names and origin

Protein names

Recommended name:
    Uronate isomerase
    EC=5.3.1.12
Alternative name(s):
    Glucuronate isomerase
    Uronic isomerase

Gene names

Name:	uxaC
Ordered Locus Names:	SFV_3133

Organism

Shigella flexneri serotype 5b (strain 8401) [Complete proteome] [HAMAP]

Taxonomic identifier

373384 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Shigella

Protein attributes

Sequence length	470 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	D-glucuronate = D-fructuronate. HAMAP MF_00675 D-galacturonate = D-tagaturonate. HAMAP MF_00675
Pathway	Carbohydrate metabolism; pentose and glucuronate interconversion. HAMAP MF_00675
Sequence similarities	Belongs to the uronate isomerase family.

Ontologies

Keywords
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glucuronate catabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	glucuronate isomerase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 470	470	Uronate isomerase HAMAP MF_00675		PRO_1000044775

Sequences

	Sequence		Length	Mass (Da)
	Q0T0H6-1 [UniParc]. Last modified September 5, 2006. Version 1. Checksum: 9E51AA7B88411281	FASTA	470	53,987
	10 20 30 40 50 60 MTPFMTEDFL LDTEFARRLY HDYAKDQPIF DYHCHLPPQQ IAEDYRFKNL YDIWLKGDHY 70 80 90 100 110 120 KWRAMRTNGV AERLCTGDAS DREKFDAWAA TVPHTIGNPL YHWTHLELRR PFGITGKLLS 130 140 150 160 170 180 PSTADEIWNE CNELLAQDNF SARGIMQQMN VKMVGTTDDP IDSLEHHAEI AKDGSFTIKV 190 200 210 220 230 240 LPSWRPDKAF NIEQATFNDY MAKLGEVSDT DIRRFADLQT ALTKRLDHFA AHGCKVSDHA 250 260 270 280 290 300 LDVVMFAEAN EAELDSILAR RLAGETLSEH EVAQFKTAVL VFLGAEYARR GWVQQYHIGA 310 320 330 340 350 360 LRNNNLRQFK LLGPDVGFDS INDRPMAEEL SKLLSKQNEE NLLPKTILYC LNPRDNEVLG 370 380 390 400 410 420 TMIGNFQGEG MPGKMQFGSG WWFNDQKDGM ERQMTQLAQL GLLSRFVGML TDSRSFLSYT 430 440 450 460 470 RHEYFRRILC QMIGRWVEAG EAPADINLLG EMVKNICFNN ARDYFAIELN

References

[1]

"Complete genome sequence of Shigella flexneri 5b and comparison with Shigella flexneri 2a." Nie H., Yang F., Zhang X., Yang J., Chen L., Wang J., Xiong Z., Peng J., Sun L., Dong J., Xue Y., Xu X., Chen S., Yao Z., Shen Y., Jin Q. BMC Genomics 7:173-173(2006) [PubMed: 16822325] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000266 Genomic DNA. Translation: ABF05189.1.
RefSeq	YP_690494.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	4207564.
GenomeReviews	Gene locus SFV_3133 in contig CP000266_GR.
KEGG	sfv:SFV_3133.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q0T0H6.
OMA	Q0T0H6. AWAKTVP.
Enzyme and pathway databases
BioCyc	SFLE373384:SFV_3133-MON.
Family and domain databases
HAMAP	MF_00675. [Tree]
InterPro	IPR003766. UxaC. [Graphical view]
Pfam	PF02614. UxaC. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

UXAC_SHIF8

Accession

Primary (citable) accession number: Q0T0H6

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	September 5, 2006
Last modified:	June 16, 2009
This is version 17 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)