ID   NANK_SHIF8              Reviewed;         291 AA.
AC   Q0T068;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 1.
DT   16-JUN-2009, entry version 18.
DE   RecName: Full=N-acetylmannosamine kinase;
DE            EC=2.7.1.60;
DE   AltName: Full=N-acetyl-D-mannosamine kinase;
DE   AltName: Full=ManNAc kinase;
GN   Name=nanK; OrderedLocusNames=SFV_3247;
OS   Shigella flexneri serotype 5b (strain 8401).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales;
OC   Enterobacteriaceae; Shigella.
OX   NCBI_TaxID=373384;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16822325; DOI=10.1186/1471-2164-7-173;
RA   Nie H., Yang F., Zhang X., Yang J., Chen L., Wang J., Xiong Z.,
RA   Peng J., Sun L., Dong J., Xue Y., Xu X., Chen S., Yao Z., Shen Y.,
RA   Jin Q.;
RT   "Complete genome sequence of Shigella flexneri 5b and comparison with
RT   Shigella flexneri 2a.";
RL   BMC Genomics 7:173-173(2006).
CC   -!- FUNCTION: Catalyzes the phosphorylation of N-acetylmannosamine
CC       (ManNAc) to ManNAc-6-P (By similarity).
CC   -!- CATALYTIC ACTIVITY: ATP + N-acyl-D-mannosamine = ADP + N-acyl-D-
CC       mannosamine 6-phosphate.
CC   -!- PATHWAY: Amino-sugar metabolism; N-acetylneuraminic acid
CC       degradation; D-fructose 6-phosphate from N-acetylneuraminic acid:
CC       step 2/5.
CC   -!- SUBUNIT: Homodimer (By similarity).
CC   -!- SIMILARITY: Belongs to the ROK (nagC/xylR) family. NanK subfamily.
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DR   EMBL; CP000266; ABF05297.1; -; Genomic_DNA.
DR   RefSeq; YP_690602.1; -.
DR   SMR; Q0T068; 1-289.
DR   GeneID; 4209285; -.
DR   GenomeReviews; CP000266_GR; SFV_3247.
DR   KEGG; sfv:SFV_3247; -.
DR   HOGENOM; Q0T068; -.
DR   OMA; Q0T068; EYQALEG.
DR   BioCyc; SFLE373384:SFV_3247-MON; -.
DR   GO; GO:0005524; F:ATP binding; IEA:HAMAP.
DR   GO; GO:0009384; F:N-acylmannosamine kinase activity; IEA:HAMAP.
DR   GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006051; P:N-acetylmannosamine metabolic process; IEA:HAMAP.
DR   HAMAP; MF_01234; -; 1.
DR   InterPro; IPR000600; ROK.
DR   Pfam; PF00480; ROK; 1.
DR   PROSITE; PS01125; ROK; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Carbohydrate metabolism; Complete proteome; Kinase;
KW   Metal-binding; Nucleotide-binding; Transferase; Zinc.
FT   CHAIN         1    291       N-acetylmannosamine kinase.
FT                                /FTId=PRO_0000301461.
FT   NP_BIND       5     12       ATP (Potential).
FT   NP_BIND     132    139       ATP (Potential).
FT   METAL       156    156       Zinc (By similarity).
FT   METAL       166    166       Zinc (By similarity).
FT   METAL       168    168       Zinc (By similarity).
FT   METAL       173    173       Zinc (By similarity).
SQ   SEQUENCE   291 AA;  29698 MW;  1F180C9C589FC1E7 CRC64;
     MTILAIDIGG TKLAAALIGA DGQIRDRREL PTPASQTPEA LRDALSALVS PLQAHAQRVA
     IASTGIIRDG SLLALNPHNL GGLLHFPLVK TLEQLTNLPT IAINDAQAAA WAEYQALEGD
     ITDMVFITVS TGVGGGVVSG GKLLTGPGGL AGHIGHTLAD PHGPVCGCGR TGCVEAIASG
     RGIAAAAQGE LAGADARTIF TRAGQGDEQA QQLIHRSART LARLIADIKA TTDCQCVVVG
     GSVGLAEGYL ALVEMYLAQE PAAFHVDLLA AHYRHDAGLL GAALLAQGEK L
//