Reviewed, UniProtKB/Swiss-Prot Q0T067 (NANE_SHIF8)

Names and origin

Protein names

Recommended name:
    Putative N-acetylmannosamine-6-phosphate 2-epimerase
    EC=5.1.3.9
Alternative name(s):
    ManNAc-6-P epimerase

Gene names

Name:	nanE
Ordered Locus Names:	SFV_3248

Organism

Shigella flexneri serotype 5b (strain 8401) [Complete proteome] [HAMAP]

Taxonomic identifier

373384 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Shigella

Protein attributes

Sequence length	229 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P) Potential.
Catalytic activity	N-acyl-D-glucosamine 6-phosphate = N-acyl-D-mannosamine 6-phosphate. HAMAP MF_01235
Pathway	Amino-sugar metabolism; N-acetylneuraminic acid degradation; D-fructose 6-phosphate from N-acetylneuraminic acid: step 3/5. HAMAP MF_01235
Sequence similarities	Belongs to the nanE family.

Ontologies

Keywords
Biological process	Carbohydrate metabolism
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	N-acetylmannosamine metabolic process Inferred from electronic annotation. Source: HAMAP
Molecular function	N-acylglucosamine-6-phosphate 2-epimerase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 229	229	Putative N-acetylmannosamine-6-phosphate 2-epimerase HAMAP MF_01235		PRO_0000301482

Sequences

	Sequence		Length	Mass (Da)
	Q0T067-1 [UniParc]. Last modified September 5, 2006. Version 1. Checksum: FA6DB3F36FEDCEFE	FASTA	229	24,088
	10 20 30 40 50 60 MSLLAQLDQK IAANGGLIVS CQPVPDSPLD KPEIVAAMAL AAEQAGAVAI RIEGVANLQA 70 80 90 100 110 120 TRAVVSVPII GIVKRDLEDS PVRITAYIED VDALAQAGAD IIAIDGTDRP RPVPVETLLA 130 140 150 160 170 180 RIHHHGLLAM TDCSTPEDGL ACQKLGAEII GTTLSGYTTP ETPEEPDLAL VKTLSEAGCR 190 200 210 220 VIAEGRYNTP AQAADAMRHG AWAVTVGSAI TRLEHICQWY NTAMKKAVL

References

[1]

"Complete genome sequence of Shigella flexneri 5b and comparison with Shigella flexneri 2a." Nie H., Yang F., Zhang X., Yang J., Chen L., Wang J., Xiong Z., Peng J., Sun L., Dong J., Xue Y., Xu X., Chen S., Yao Z., Shen Y., Jin Q. BMC Genomics 7:173-173(2006) [PubMed: 16822325] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000266 Genomic DNA. Translation: ABF05298.1.
RefSeq	YP_690603.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	4209286.
GenomeReviews	Gene locus SFV_3248 in contig CP000266_GR.
KEGG	sfv:SFV_3248.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q0T067.
OMA	Q0T067. YNTPELA.
Enzyme and pathway databases
BioCyc	SFLE373384:SFV_3248-MON.
Family and domain databases
HAMAP	MF_01235. [Tree]
InterPro	IPR007260. NanE. [Graphical view]
Pfam	PF04131. NanE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

NANE_SHIF8

Accession

Primary (citable) accession number: Q0T067

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 11, 2007
Last sequence update:	September 5, 2006
Last modified:	June 16, 2009
This is version 21 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)