ID   RHAA_SHIF8              Reviewed;         419 AA.
AC   Q0SZ93;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 1.
DT   16-JUN-2009, entry version 21.
DE   RecName: Full=L-rhamnose isomerase;
DE            EC=5.3.1.14;
GN   Name=rhaA; OrderedLocusNames=SFV_3592;
OS   Shigella flexneri serotype 5b (strain 8401).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales;
OC   Enterobacteriaceae; Shigella.
OX   NCBI_TaxID=373384;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16822325; DOI=10.1186/1471-2164-7-173;
RA   Nie H., Yang F., Zhang X., Yang J., Chen L., Wang J., Xiong Z.,
RA   Peng J., Sun L., Dong J., Xue Y., Xu X., Chen S., Yao Z., Shen Y.,
RA   Jin Q.;
RT   "Complete genome sequence of Shigella flexneri 5b and comparison with
RT   Shigella flexneri 2a.";
RL   BMC Genomics 7:173-173(2006).
CC   -!- CATALYTIC ACTIVITY: L-rhamnose = L-rhamnulose.
CC   -!- COFACTOR: Binds 1 manganese ion per subunit (By similarity).
CC   -!- PATHWAY: Carbohydrate degradation; L-rhamnose degradation;
CC       glycerone phosphate from L-rhamnose: step 1/3.
CC   -!- SUBUNIT: Homotetramer (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the rhamnose isomerase family.
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DR   EMBL; CP000266; ABF05622.1; -; Genomic_DNA.
DR   RefSeq; YP_690927.1; -.
DR   SMR; Q0SZ93; 1-418.
DR   GeneID; 4207545; -.
DR   GenomeReviews; CP000266_GR; SFV_3592.
DR   KEGG; sfv:SFV_3592; -.
DR   HOGENOM; Q0SZ93; -.
DR   OMA; Q0SZ93; GSHEFYM.
DR   BioCyc; SFLE373384:SFV_3592-MON; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0008740; F:L-rhamnose isomerase activity; IEA:HAMAP.
DR   GO; GO:0030145; F:manganese ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0019299; P:rhamnose metabolic process; IEA:HAMAP.
DR   HAMAP; MF_00541; -; 1.
DR   InterPro; IPR009308; Rhamnose_isomerase.
DR   InterPro; IPR013022; Xyl_isomerase-like_TIM-brl.
DR   Gene3D; G3DSA:3.20.20.150; Xyl_isomerase-like_TIM-brl; 1.
DR   Pfam; PF06134; RhaA; 1.
DR   TIGRFAMs; TIGR01748; rhaA; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Cytoplasm; Isomerase; Manganese; Metal-binding;
KW   Rhamnose metabolism.
FT   CHAIN         1    419       L-rhamnose isomerase.
FT                                /FTId=PRO_1000017722.
FT   METAL       262    262       Manganese (By similarity).
FT   METAL       294    294       Manganese (By similarity).
FT   METAL       296    296       Manganese (By similarity).
SQ   SEQUENCE   419 AA;  47109 MW;  D23B96FDD53CEB7B CRC64;
     MTTQLEQAWE LAKQRFAAVG IDVEEALRQL DRLPVSMHCW QGDDVSGFEN PEGSLTGGIQ
     ATGNYPGKAR NASELRADLE QAMRLIPGPK RLNLHAIYLE SDTPVSRDQI KPEHFKNWVE
     WAKANQLGLD FNPSCFSHPL SADGFTLSHP DDSIRQFWID HCKASRRVSA YFGEQLGTPS
     VMNIWIPDGM KDITVDRLAP RQRLLAALDE VISEKLNPAH HIDAVESKLF GIGAESYTVG
     SNEFYMGYAT SRQTALCLDA GHFHPTEVIS DKISAAMLYV PQLLLHVSRP VRWDSDHVVL
     LDDETQAIAS EIVRHDLFDR VHIGLDFFDA SINRIAAWVI GTRNMKKALL RALLEPTAEL
     RKLEAAGDYT ARLALLEEQK SLPRQAVWEM YCQRHDTPAG SEWLESVRAY EKAILSQRG
//