ID   GPPA_SHIF8              Reviewed;         494 AA.
AC   Q0SYW9;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 1.
DT   16-JUN-2009, entry version 15.
DE   RecName: Full=Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase;
DE            EC=3.6.1.40;
DE   AltName: Full=Guanosine pentaphosphate phosphohydrolase;
DE   AltName: Full=pppGpp-5'-phosphohydrolase;
GN   Name=gppA; OrderedLocusNames=SFV_3725;
OS   Shigella flexneri serotype 5b (strain 8401).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales;
OC   Enterobacteriaceae; Shigella.
OX   NCBI_TaxID=373384;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16822325; DOI=10.1186/1471-2164-7-173;
RA   Nie H., Yang F., Zhang X., Yang J., Chen L., Wang J., Xiong Z.,
RA   Peng J., Sun L., Dong J., Xue Y., Xu X., Chen S., Yao Z., Shen Y.,
RA   Jin Q.;
RT   "Complete genome sequence of Shigella flexneri 5b and comparison with
RT   Shigella flexneri 2a.";
RL   BMC Genomics 7:173-173(2006).
CC   -!- FUNCTION: Conversion of pppGpp to ppGpp. Guanosine pentaphosphate
CC       (pppGpp) is a cytoplasmic signaling molecule which together with
CC       ppGpp controls the "stringent response", an adaptive process that
CC       allows bacteria to respond to amino acid starvation, resulting in
CC       the coordinated regulation of numerous cellular activities (By
CC       similarity).
CC   -!- CATALYTIC ACTIVITY: Guanosine 5'-triphosphate,3'-diphosphate +
CC       H(2)O = guanosine 5'-diphosphate,3'-diphosphate + phosphate.
CC   -!- PATHWAY: Purine metabolism; ppGpp biosynthesis; ppGpp from GTP:
CC       step 1/2.
CC   -!- SIMILARITY: Belongs to the gppA/ppx family. GppA subfamily.
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DR   EMBL; CP000266; ABF05746.1; -; Genomic_DNA.
DR   RefSeq; YP_691051.1; -.
DR   GeneID; 4211124; -.
DR   GenomeReviews; CP000266_GR; SFV_3725.
DR   KEGG; sfv:SFV_3725; -.
DR   HOGENOM; Q0SYW9; -.
DR   OMA; Q0SYW9; QYTDLGW.
DR   BioCyc; SFLE373384:SFV_3725-MON; -.
DR   GO; GO:0008894; F:guanosine-5'-triphosphate,3'-diphosphate di...; IEA:HAMAP.
DR   HAMAP; MF_01550; -; 1.
DR   InterPro; IPR003695; Ppx_GppA.
DR   Pfam; PF02541; Ppx-GppA; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Hydrolase.
FT   CHAIN         1    494       Guanosine-5'-triphosphate,3'-diphosphate
FT                                pyrophosphatase.
FT                                /FTId=PRO_0000314499.
SQ   SEQUENCE   494 AA;  54972 MW;  DE8D75405A41CF5E CRC64;
     MGSTSSLYAA IDLGSNSFHM LVVREVAGSI QTLTRIKRKV RLAAGLNSEN DLSNEAMERG
     WQCLRLFAER LQDIPPSQIR VVATATLRLA VNAGDFIAKA QEILGCPVQV ISGEEEARLI
     YQGVAHTTGG ADQRLVVDIS GASTELVTGT GAQTTSLFSL SMGCVTWLER YFADRNLGQE
     NFDAAEKAAR EVLRPVADEL RYHGWKVCVG ASGTVQALQE IMMAQGMDER ITLEKLQQLK
     QRAIHCGRLE ELEIDGLTLE RALVFPSGLA ILIAIFTELN IQCMTLAGGA LREGLVYGML
     HLAVEQDIRS RTLRNIQRRF MIDIDQAQRV AKVAANFFDQ VENEWHLEAI SRDLLISACQ
     LHEIGLSVDF KQAPQHAAYL VRNLDLPGFT PAQKKLLATL LLNQTNPVDL SSLHQQNAVP
     PRVAEQLCRL LRLAIIFASR RRDDLVPEMT LQANHELLTL TLPQGWLTQH PLGKEIIAQE
     NQWQSYVHWP LEVH
//