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Q0SYW9

- GPPA_SHIF8

UniProt

Q0SYW9 - GPPA_SHIF8

Protein

Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase

Gene

gppA

Organism
Shigella flexneri serotype 5b (strain 8401)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 46 (01 Oct 2014)
      Sequence version 1 (05 Sep 2006)
      Previous versions | rss
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    Functioni

    Conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the "stringent response", an adaptive process that allows bacteria to respond to amino acid starvation, resulting in the coordinated regulation of numerous cellular activities.UniRule annotation

    Catalytic activityi

    Guanosine 5'-triphosphate,3'-diphosphate + H2O = guanosine 3',5'-bis(diphosphate) + phosphate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. guanosine-5'-triphosphate,3'-diphosphate diphosphatase activity Source: UniProtKB-EC

    GO - Biological processi

    1. guanosine pentaphosphate catabolic process Source: InterPro
    2. guanosine tetraphosphate biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase

    Enzyme and pathway databases

    BioCyciSFLE373384:GHZM-3721-MONOMER.
    UniPathwayiUPA00908; UER00884.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Guanosine-5'-triphosphate,3'-diphosphate pyrophosphataseUniRule annotation (EC:3.6.1.40UniRule annotation)
    Alternative name(s):
    Guanosine pentaphosphate phosphohydrolaseUniRule annotation
    pppGpp-5'-phosphohydrolaseUniRule annotation
    Gene namesi
    Name:gppAUniRule annotation
    Ordered Locus Names:SFV_3725
    OrganismiShigella flexneri serotype 5b (strain 8401)
    Taxonomic identifieri373384 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeShigella
    ProteomesiUP000000659: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 494494Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatasePRO_0000314499Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi373384.SFV_3725.

    Structurei

    3D structure databases

    ProteinModelPortaliQ0SYW9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GppA/Ppx family. GppA subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0248.
    HOGENOMiHOG000258672.
    KOiK01524.
    OMAiGLHIEYK.
    OrthoDBiEOG6M6JN6.

    Family and domain databases

    HAMAPiMF_01550. GppA.
    InterProiIPR023709. Guo-5TP_3DP_PyrP.
    IPR003695. Ppx_GppA.
    [Graphical view]
    PfamiPF02541. Ppx-GppA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q0SYW9-1 [UniParc]FASTAAdd to Basket

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    MGSTSSLYAA IDLGSNSFHM LVVREVAGSI QTLTRIKRKV RLAAGLNSEN    50
    DLSNEAMERG WQCLRLFAER LQDIPPSQIR VVATATLRLA VNAGDFIAKA 100
    QEILGCPVQV ISGEEEARLI YQGVAHTTGG ADQRLVVDIS GASTELVTGT 150
    GAQTTSLFSL SMGCVTWLER YFADRNLGQE NFDAAEKAAR EVLRPVADEL 200
    RYHGWKVCVG ASGTVQALQE IMMAQGMDER ITLEKLQQLK QRAIHCGRLE 250
    ELEIDGLTLE RALVFPSGLA ILIAIFTELN IQCMTLAGGA LREGLVYGML 300
    HLAVEQDIRS RTLRNIQRRF MIDIDQAQRV AKVAANFFDQ VENEWHLEAI 350
    SRDLLISACQ LHEIGLSVDF KQAPQHAAYL VRNLDLPGFT PAQKKLLATL 400
    LLNQTNPVDL SSLHQQNAVP PRVAEQLCRL LRLAIIFASR RRDDLVPEMT 450
    LQANHELLTL TLPQGWLTQH PLGKEIIAQE NQWQSYVHWP LEVH 494
    Length:494
    Mass (Da):54,972
    Last modified:September 5, 2006 - v1
    Checksum:iDE8D75405A41CF5E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000266 Genomic DNA. Translation: ABF05746.1.
    RefSeqiWP_000535983.1. NC_008258.1.
    YP_691051.1. NC_008258.1.

    Genome annotation databases

    EnsemblBacteriaiABF05746; ABF05746; SFV_3725.
    GeneIDi4211124.
    KEGGisfv:SFV_3725.
    PATRICi18731591. VBIShiFle33408_4242.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000266 Genomic DNA. Translation: ABF05746.1 .
    RefSeqi WP_000535983.1. NC_008258.1.
    YP_691051.1. NC_008258.1.

    3D structure databases

    ProteinModelPortali Q0SYW9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 373384.SFV_3725.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABF05746 ; ABF05746 ; SFV_3725 .
    GeneIDi 4211124.
    KEGGi sfv:SFV_3725.
    PATRICi 18731591. VBIShiFle33408_4242.

    Phylogenomic databases

    eggNOGi COG0248.
    HOGENOMi HOG000258672.
    KOi K01524.
    OMAi GLHIEYK.
    OrthoDBi EOG6M6JN6.

    Enzyme and pathway databases

    UniPathwayi UPA00908 ; UER00884 .
    BioCyci SFLE373384:GHZM-3721-MONOMER.

    Family and domain databases

    HAMAPi MF_01550. GppA.
    InterProi IPR023709. Guo-5TP_3DP_PyrP.
    IPR003695. Ppx_GppA.
    [Graphical view ]
    Pfami PF02541. Ppx-GppA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of Shigella flexneri 5b and comparison with Shigella flexneri 2a."
      Nie H., Yang F., Zhang X., Yang J., Chen L., Wang J., Xiong Z., Peng J., Sun L., Dong J., Xue Y., Xu X., Chen S., Yao Z., Shen Y., Jin Q.
      BMC Genomics 7:173-173(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 8401.

    Entry informationi

    Entry nameiGPPA_SHIF8
    AccessioniPrimary (citable) accession number: Q0SYW9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: September 5, 2006
    Last modified: October 1, 2014
    This is version 46 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3