Reviewed, UniProtKB/Swiss-Prot Q0SY04 (NUDC_SHIF8)

Names and origin

Protein names

Recommended name:
    NADH pyrophosphatase
    EC=3.6.1.22

Gene names

Name:	nudC
Ordered Locus Names:	SFV_4068

Organism

Shigella flexneri serotype 5b (strain 8401) [Complete proteome] [HAMAP]

Taxonomic identifier

373384 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Shigella

Protein attributes

Sequence length	257 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	NAD+ + H2O = AMP + NMN. HAMAP MF_00297
Cofactor	Divalent ions. Manganese or magnesium By similarity.
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the Nudix hydrolase family. NudC subfamily.

Ontologies

Keywords
Ligand	Magnesium Manganese NAD
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	NAD+ diphosphatase activity Inferred from electronic annotation. Source: HAMAP magnesium ion binding Inferred from electronic annotation. Source: HAMAP manganese ion binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 257	257	NADH pyrophosphatase HAMAP MF_00297		PRO_1000021915
Regions
	Motif	159 – 180	22	Nudix box HAMAP MF_00297

Sequences

	Sequence		Length	Mass (Da)
	Q0SY04-1 [UniParc]. Last modified September 5, 2006. Version 1. Checksum: D488D3DD32A83FAB	FASTA	257	29,703
	10 20 30 40 50 60 MDRIIEKLDH GWWVVSHEQK LWLPKGELPY GEAANFDLVG QRALQIGEWQ GEPVWLIQQQ 70 80 90 100 110 120 RRHDMGSVRQ VIDLDVGLFQ LAGRGVQLAE FYRSHKYCGY CGHEMYPSKT EWAMLCSHCR 130 140 150 160 170 180 ERYYPQIAPC IIVAIRRDDS ILLAQHTRHR NGVHTVLAGF VEVGETLEQA VAREVMEESG 190 200 210 220 230 240 IKVKNLRYVT SQPWPFPQSL MTAFMAEYDS GDIVIDPKEL LEANWYRYDD LPLLPPPGTV 250 ARRLIEDTVA MCRAEYE

References

[1]

"Complete genome sequence of Shigella flexneri 5b and comparison with Shigella flexneri 2a." Nie H., Yang F., Zhang X., Yang J., Chen L., Wang J., Xiong Z., Peng J., Sun L., Dong J., Xue Y., Xu X., Chen S., Yao Z., Shen Y., Jin Q. BMC Genomics 7:173-173(2006) [PubMed: 16822325] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000266 Genomic DNA. Translation: ABF06061.1.
RefSeq	YP_691366.1.
3D structure databases
SMR	Q0SY04. Positions 1-257.
ModBase	Search...
Genome annotation databases
GeneID	4209202.
GenomeReviews	Gene locus SFV_4068 in contig CP000266_GR.
KEGG	sfv:SFV_4068.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q0SY04.
OMA	Q0SY04. SPCIIVA.
Enzyme and pathway databases
BioCyc	SFLE373384:SFV_4068-MON.
Family and domain databases
HAMAP	MF_00297. [Tree]
InterPro	IPR015375. NADH_PPase-like_N. IPR000086. NUDIX_hydrolase_core. IPR015376. Znr_NADH_PPase. [Graphical view]
Gene3D	G3DSA:3.90.79.10. NUDIX_hydrolase. 1 hit.
Pfam	PF00293. NUDIX. 1 hit. PF09296. NUDIX-like. 1 hit. PF09297. zf-NADH-PPase. 1 hit. [Graphical view]
PROSITE	PS00893. NUDIX. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

NUDC_SHIF8

Accession

Primary (citable) accession number: Q0SY04

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	September 5, 2006
Last modified:	June 16, 2009
This is version 21 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)