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Q0SY04 (NUDC_SHIF8) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 38. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
NADH pyrophosphatase
EC=3.6.1.22
Gene names
Name:nudC
Ordered Locus Names:SFV_4068
OrganismShigella flexneri serotype 5b (strain 8401) [Complete proteome] [HAMAP]
Taxonomic identifier373384 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Shigella

Protein attributes

Sequence length257 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

NAD+ + H2O = AMP + NMN. HAMAP MF_00297

Cofactor

Divalent metal cations. Magnesium or manganese By similarity.

Binds 1 zinc ion per subunit By similarity. HAMAP MF_00297

Subunit structure

Homodimer By similarity. HAMAP MF_00297

Sequence similarities

Belongs to the Nudix hydrolase family. NudC subfamily.

Contains 1 nudix hydrolase domain.

Ontologies

Keywords
   LigandMagnesium
Manganese
Metal-binding
NAD
Zinc
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Molecular functionNAD+ diphosphatase activity

Inferred from electronic annotation. Source: EC

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 257257NADH pyrophosphatase HAMAP MF_00297
PRO_1000021915

Regions

Domain125 – 248124Nudix hydrolase
Motif159 – 18022Nudix box HAMAP MF_00297

Sites

Metal binding981Zinc By similarity
Metal binding1011Zinc By similarity
Metal binding1161Zinc By similarity
Metal binding1191Zinc By similarity
Metal binding1741Divalent metal cation By similarity
Metal binding1781Divalent metal cation By similarity

Sequences

Sequence LengthMass (Da)Tools
Q0SY04 [UniParc].

Last modified September 5, 2006. Version 1.
Checksum: D488D3DD32A83FAB

FASTA25729,703
        10         20         30         40         50         60 
MDRIIEKLDH GWWVVSHEQK LWLPKGELPY GEAANFDLVG QRALQIGEWQ GEPVWLIQQQ 

        70         80         90        100        110        120 
RRHDMGSVRQ VIDLDVGLFQ LAGRGVQLAE FYRSHKYCGY CGHEMYPSKT EWAMLCSHCR 

       130        140        150        160        170        180 
ERYYPQIAPC IIVAIRRDDS ILLAQHTRHR NGVHTVLAGF VEVGETLEQA VAREVMEESG 

       190        200        210        220        230        240 
IKVKNLRYVT SQPWPFPQSL MTAFMAEYDS GDIVIDPKEL LEANWYRYDD LPLLPPPGTV 

       250 
ARRLIEDTVA MCRAEYE

« Hide

References

[1]"Complete genome sequence of Shigella flexneri 5b and comparison with Shigella flexneri 2a."
Nie H., Yang F., Zhang X., Yang J., Chen L., Wang J., Xiong Z., Peng J., Sun L., Dong J., Xue Y., Xu X., Chen S., Yao Z., Shen Y., Jin Q.
BMC Genomics 7:173-173(2006) [PubMed: 16822325] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 8401.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000266 Genomic DNA. Translation: ABF06061.1.
RefSeqYP_691366.1. NC_008258.1.

3D structure databases

ProteinModelPortalQ0SY04.
SMRQ0SY04. Positions 1-256.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ0SY04.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBESCT00000095731; EBESCP00000091927; EBESCG00000094775.
GeneID4209202.
GenomeReviewsGene locus SFV_4068 in contig CP000266_GR.
KEGGsfv:SFV_4068.
PATRIC18732373. VBIShiFle33408_4616.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2816.
GeneTreeEBGT00050000011158.
HOGENOMHBG736436.
OMAPHSLMMG.
ProtClustDBPRK00241.

Enzyme and pathway databases

BioCycSFLE373384:SFV_4068-MONOMER.

Family and domain databases

HAMAPMF_00297. Nudix_NudC.
[Tree]
InterProIPR015375. NADH_PPase-like_N.
IPR022925. NADH_pyroPase_NudC.
IPR020084. NUDIX_hydrolase_CS.
IPR000086. NUDIX_hydrolase_dom.
IPR015797. NUDIX_hydrolase_dom-like.
IPR015376. Znr_NADH_PPase.
[Graphical view]
Gene3DG3DSA:3.90.79.10. NUDIX_hydrolase. 1 hit.
KOK03426.
PfamPF00293. NUDIX. 1 hit.
PF09296. NUDIX-like. 1 hit.
PF09297. zf-NADH-PPase. 1 hit.
[Graphical view]
SUPFAMSSF55811. NUDIX_hydrolase. 2 hits.
PROSITEPS51462. NUDIX. 1 hit.
PS00893. NUDIX_BOX. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameNUDC_SHIF8
AccessionPrimary (citable) accession number: Q0SY04
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: September 5, 2006
Last modified: January 25, 2012
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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