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Q0SXY9 (Q0SXY9_SHIF8) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 55. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesSubmitted name:
B12-dependent methionine synthase EMBL ABF06076.1
Gene names
Name:metH EMBL ABF06076.1
Ordered Locus Names:SFV_4090
OrganismShigella flexneri serotype 5b (strain 8401) [Complete proteome] [HAMAP]
Taxonomic identifier373384 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Shigella ›

Protein attributes

Sequence length1227 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Cofactor

Binds 1 zinc ion per subunit By similarity. PIRSR PIRSR000381-1

Cobalamin By similarity. PIRSR PIRSR000381-2

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region834 – 8352Cobalamin-binding By similarity PIRSR PIRSR000381-2
Region1189 – 11902S-adenosyl-L-methionine binding By similarity PIRSR PIRSR000381-2

Sites

Metal binding2471Zinc By similarity PIRSR PIRSR000381-1
Metal binding3101Zinc By similarity PIRSR PIRSR000381-1
Metal binding3111Zinc By similarity PIRSR PIRSR000381-1
Metal binding7591Cobalt (cobalamin axial ligand) By similarity PIRSR PIRSR000381-1
Binding site9461S-adenosyl-L-methionine By similarity PIRSR PIRSR000381-2
Binding site11341S-adenosyl-L-methionine; via carbonyl oxygen By similarity PIRSR PIRSR000381-2
Binding site11381Cobalamin; via carbonyl oxygen By similarity PIRSR PIRSR000381-2

Sequences

Sequence LengthMass (Da)Tools
Q0SXY9 [UniParc].

Last modified September 5, 2006. Version 1.
Checksum: 2E28CD6AD800CAC5

FASTA1,227135,895
        10         20         30         40         50         60 
MSSKVEQLRA QLNERILVLD GGMGTMIQSY RLNEADFRGE RFADWPCDLK GNNDLLVLSK 

        70         80         90        100        110        120 
PEVIAAIHNA YFEAGADIIE TNTFNSTTIA MADYQMESLS AEINFAAAKL ARACADEWTA 

       130        140        150        160        170        180 
RTPEKPRYVA GVLGPTNRTA SISPDVNDPA FRNITFDQLA AAYRESTKAL VEGGADLILI 

       190        200        210        220        230        240 
ETVFDTLNAK AAVFAVKTEF EALGVELPIM ISGIITDASG RTLSGQTTEA FYNSLRHAEA 

       250        260        270        280        290        300 
LTFGLNCALG PDELRQYVQE LSRIAECYVT AHPNAGLPNA FGEYDLDADT MAKQIREWAQ 

       310        320        330        340        350        360 
AGFLNIVGGC CGTTPQHIAA MSRAVEGLAP RKLPEIPVAC RLSGLEPLNI GDDSLFVNVG 

       370        380        390        400        410        420 
ERTNVTGSAK FKRLIKEEKY SEALDVARQQ VENGAQIIDI NMDEGMLDAE AAMVRFLNLI 

       430        440        450        460        470        480 
AGEPDIARVP IMIDSSKWDV IEKGLKCIQG KGIVNSISMK EGVDAFIHHA KLLRRYGAAV 

       490        500        510        520        530        540 
VVMAFDEQGQ ADTRARKIEI CRRAYKILTE EVGFPPEDII FDPNIFAVAT GIEEHNNYAQ 

       550        560        570        580        590        600 
DFIGACEDIK RELPHALISG GVSNVSFSFR GNDPVREAIH AVFLYYAIRN GMDMGIVNAG 

       610        620        630        640        650        660 
QLAIYDDLPA ELRDAVEDVI LNRRDDGTER LLELAEKYRG SKADDTANAQ QAEWRSWDVN 

       670        680        690        700        710        720 
KRLEYSLVKG ITEFIEQDTE EARQQATRPI EVIEGPLMDG MNVVGDLFGE GKMFLPQVVK 

       730        740        750        760        770        780 
SARVMKQAVA YLEPFIEASK EQGKTNGKMV IATVKGDVHD IGKNIVGVVL QCNNYEIVDL 

       790        800        810        820        830        840 
GVMVPAEKIL RIAKEVNADL IGLSGLITPS LDEMVNVAKE MERQGFAIPL LIGGATTSKA 

       850        860        870        880        890        900 
HTAVKIEQNY SGPTVYVQNA SRTVGVVAAL LSDTQRDDFV ARTCKEYETV RIQHGRKKPR 

       910        920        930        940        950        960 
TPPVTLEAAR DNDFAFDWQA YTPPVAHRLG VQEVEASIET LRNYIDWTPF FMTWSLAGKY 

       970        980        990       1000       1010       1020 
PRILEDEVVG VEAQRLFKDA NDMLDKLSAE KTLNPRGVVG LFPANRVGDD IEIYRDETRT 

      1030       1040       1050       1060       1070       1080 
HVINVSHHLR QQTEKTGFAN YCLADFVAPK LSGKADYIGA FAVTGGLEED ALADAFEAQH 

      1090       1100       1110       1120       1130       1140 
DDYNKIMVKA LADRLAEAFA EYLHERVRKV YWGYAPNENL SNEELIRENY QGIRPAPGYP 

      1150       1160       1170       1180       1190       1200 
ACPEHTEKAT IWELLEVEKH TGMKLTESFA MWPGASVSGW YFSHPDSKYY AVAQIQRDQV 

      1210       1220 
EDYARRKGMS VSDVERWLAP NLGYDAD

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References

[1]"Complete genome sequence of Shigella flexneri 5b and comparison with Shigella flexneri 2a."
Nie H., Yang F., Zhang X., Yang J., Chen L., Wang J., Xiong Z., Peng J., Sun L., Dong J., Xue Y., Xu X., Chen S., Yao Z., Shen Y., Jin Q.
BMC Genomics 7:173-173(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 8401.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000266 Genomic DNA. Translation: ABF06076.1.
RefSeqYP_691381.1. NC_008258.1.

3D structure databases

ProteinModelPortalQ0SXY9.
SMRQ0SXY9. Positions 651-1227.
ModBaseSearch...

Protein-protein interaction databases

STRING373384.SFV_4090.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABF06076; ABF06076; SFV_4090.
GeneID4210929.
KEGGsfv:SFV_4090.
PATRIC18732433. VBIShiFle33408_4642.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1410.
HOGENOMHOG000251409.
KOK00548.
OMAVRKEFWG.
ProtClustDBPRK09490.

Enzyme and pathway databases

BioCycSFLE373384:GHZM-4095-MONOMER.

Family and domain databases

Gene3D1.10.1240.10. 1 hit.
3.10.196.10. 1 hit.
3.20.20.20. 1 hit.
3.20.20.330. 1 hit.
3.40.50.280. 1 hit.
InterProIPR003759. Cbl-bd_cap.
IPR006158. Cobalamin-bd.
IPR011005. Dihydropteroate_synth-like.
IPR011822. MetH.
IPR000489. Pterin-binding.
IPR003726. S_MeTrfase.
IPR004223. VitB12-dep_Met_synth_activ_dom.
[Graphical view]
PANTHERPTHR21091:SF9. PTHR21091:SF9. 1 hit.
PfamPF02310. B12-binding. 1 hit.
PF02607. B12-binding_2. 1 hit.
PF02965. Met_synt_B12. 1 hit.
PF00809. Pterin_bind. 1 hit.
PF02574. S-methyl_trans. 1 hit.
[Graphical view]
PIRSFPIRSF000381. MetH. 1 hit.
SMARTSM01018. B12-binding_2. 1 hit.
[Graphical view]
SUPFAMSSF52242. Cbl-bd. 1 hit.
SSF51717. DHP_synth_like. 1 hit.
SSF56507. Met_synth_B12. 1 hit.
SSF47644. Met_synth_Cbl-bd. 1 hit.
SSF82282. S_methyl_trans. 1 hit.
TIGRFAMsTIGR02082. metH. 1 hit.
PROSITEPS50974. ADOMET_ACTIVATION. 1 hit.
PS51332. B12_BINDING. 1 hit.
PS51337. B12_BINDING_NTER. 1 hit.
PS50970. HCY. 1 hit.
PS50972. PTERIN_BINDING. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameQ0SXY9_SHIF8
AccessionPrimary (citable) accession number: Q0SXY9
Entry history
Integrated into UniProtKB/TrEMBL: September 5, 2006
Last sequence update: September 5, 2006
Last modified: May 1, 2013
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info