Q0SXG9 (Q0SXG9_SHIF8) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Inorganic pyrophosphatase HAMAP-Rule MF_00209
EC=3.6.1.1 HAMAP-Rule MF_00209

Alternative name(s):
Pyrophosphate phospho-hydrolase HAMAP-Rule MF_00209

Gene names

Name:	ppa HAMAP-Rule MF_00209 EMBL ABF06246.1
Ordered Locus Names:	SFV_4265

Organism

Shigella flexneri serotype 5b (strain 8401) [Complete proteome] [HAMAP]

Taxonomic identifier

373384 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Shigella › Shigella flexneri › Shigella flexneri 5

Protein attributes

Sequence length	176 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Diphosphate + H2O = 2 phosphate. HAMAP-Rule MF_00209
Cofactor	Binds 4 magnesium ions per subunit. Other metal ions can support activity, but at a lower rate. Two magnesium ions are required for the activation of the enzyme and are present before substrate binds, two additional magnesium ions form complexes with substrate and product By similarity. HAMAP-Rule MF_00209
Subcellular location	Cytoplasm By similarity HAMAP-Rule MF_00209.
Sequence similarities	Belongs to the PPase family. HAMAP-Rule MF_00209

Ontologies

Keywords
Cellular component	Cytoplasm HAMAP-Rule MF_00209
Ligand	Magnesium HAMAP-Rule MF_00209 Metal-binding HAMAP-Rule MF_00209
Molecular function	Hydrolase HAMAP-Rule MF_00209
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	phosphate-containing compound metabolic process Inferred from electronic annotation. Source: InterPro
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	inorganic diphosphatase activity Inferred from electronic annotation. Source: HAMAP magnesium ion binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Metal binding	66	1	Magnesium 1 By similarity HAMAP-Rule MF_00209
	Metal binding	71	1	Magnesium 1 By similarity HAMAP-Rule MF_00209
	Metal binding	71	1	Magnesium 2 By similarity HAMAP-Rule MF_00209
	Metal binding	103	1	Magnesium 1 By similarity HAMAP-Rule MF_00209

Sequences

	Sequence		Length	Mass (Da)
	Q0SXG9 [UniParc]. Last modified September 5, 2006. Version 1. Checksum: EA91831F3F39ABFA	FASTA	176	19,718
	10 20 30 40 50 60 MSLLNVPAGK DLPEDIYVVI EIPANADPIK YEIDKESGAL FVDRFMSTAM FYPCNYGYIN 70 80 90 100 110 120 HTLSLDGDPV DVLVPTPYPL QPGSVIRCRP VAVLKMTDEA GEDAKLVAVP HSKLSKEYDH 130 140 150 160 170 IKDVNDLPEL LKAQIAHFFE HYKDLEKGKW VKVEGWENAE AAKAEIVASF ERAKNK

References

[1]

"Complete genome sequence of Shigella flexneri 5b and comparison with Shigella flexneri 2a." Nie H., Yang F., Zhang X., Yang J., Chen L., Wang J., Xiong Z., Peng J., Sun L., Dong J., Xue Y., Xu X., Chen S., Yao Z., Shen Y., Jin Q. BMC Genomics 7:173-173(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 8401.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000266 Genomic DNA. Translation: ABF06246.1.
RefSeq	YP_691551.1. NC_008258.1.
3D structure databases
ProteinModelPortal	Q0SXG9.
SMR	Q0SXG9. Positions 2-176.
ModBase	Search...
Protein-protein interaction databases
STRING	373384.SFV_4265.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABF06246; ABF06246; SFV_4265.
GeneID	4210459.
KEGG	sfv:SFV_4265.
PATRIC	18732848. VBIShiFle33408_4848.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0221.
HOGENOM	HOG000236473.
KO	K01507.
OMA	AMVIMEE.
ProtClustDB	PRK01250.
Enzyme and pathway databases
BioCyc	SFLE373384:GHZM-4269-MONOMER.
Family and domain databases
Gene3D	3.90.80.10. 1 hit.
HAMAP	MF_00209. Inorganic_PPase.
InterPro	IPR008162. Pyrophosphatase. [Graphical view]
PANTHER	PTHR10286. PTHR10286. 1 hit.
Pfam	PF00719. Pyrophosphatase. 1 hit. [Graphical view]
SUPFAM	SSF50324. Pyrophosphatase. 1 hit.
PROSITE	PS00387. PPASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q0SXG9_SHIF8

Accession

Primary (citable) accession number: Q0SXG9

Entry history

Integrated into UniProtKB/TrEMBL:	September 5, 2006
Last sequence update:	September 5, 2006
Last modified:	May 1, 2013
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)