Q0SX88 (ULAE_SHIF8) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
L-ribulose-5-phosphate 3-epimerase ulaE
EC=5.1.3.22

Alternative name(s):
L-ascorbate utilization protein E
L-xylulose-5-phosphate 3-epimerase

Gene names

Name:	ulaE
Ordered Locus Names:	SFV_4353

Organism

Shigella flexneri serotype 5b (strain 8401) [Complete proteome] [HAMAP]

Taxonomic identifier

373384 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Shigella

Protein attributes

Sequence length	284 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Catalyzes the isomerization of L-xylulose-5-phosphate to L-ribulose-5-phosphate. Is involved in the anaerobic L-ascorbate utilization By similarity. HAMAP MF_01951
Catalytic activity	L-ribulose 5-phosphate = L-xylulose 5-phosphate. HAMAP MF_01951
Pathway	Cofactor degradation; L-ascorbate degradation; D-xylulose 5-phosphate from L-ascorbate: step 3/4. HAMAP MF_01951
Induction	Induced by L-ascorbate. Repressed by ulaR By similarity. HAMAP MF_01951
Sequence similarities	Belongs to the HUMPI family.

Ontologies

Keywords
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	carbohydrate metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	L-ribulose-5-phosphate 3-epimerase activity Inferred from electronic annotation. Source: EC intramolecular oxidoreductase activity, interconverting aldoses and ketoses Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 284	284	L-ribulose-5-phosphate 3-epimerase ulaE HAMAP MF_01951		PRO_1000070635

Sequences

	Sequence		Length	Mass (Da)
	Q0SX88 [UniParc]. Last modified September 5, 2006. Version 1. Checksum: 4138EA24F37E0ACE	FASTA	284	32,079
	10 20 30 40 50 60 MLSKQIPLGI YEKALPAGEC WLERLRLAKT LGFDFVEMSV DETNERLSRL DWSRVQRLAL 70 80 90 100 110 120 VNAIVETGVR VPSMCLSAHR RFPLVSEDDA VRAQGLEIMR KAIQFAQDVG IRVIQLSGYD 130 140 150 160 170 180 VYYQEANNET RRRFRDGLKE SVEMASRAQV TLAMEIMDYP LMNSISKALG YAHYLNNPWF 190 200 210 220 230 240 QLYPDIGNLS AWDNDVQMEL QAGIGHIVAV HVKDTKPGVF KNVPFGEGVV DFERCFETLK 250 260 270 280 QSGYCGPYLI EMWSETAEDP AAEVVKACDW VKARMAKAGM VEAA

References

[1]

"Complete genome sequence of Shigella flexneri 5b and comparison with Shigella flexneri 2a." Nie H., Yang F., Zhang X., Yang J., Chen L., Wang J., Xiong Z., Peng J., Sun L., Dong J., Xue Y., Xu X., Chen S., Yao Z., Shen Y., Jin Q. BMC Genomics 7:173-173(2006) [PubMed: 16822325] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 8401.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000266 Genomic DNA. Translation: ABF06327.1.
RefSeq	YP_691632.1. NC_008258.1.
3D structure databases
ProteinModelPortal	Q0SX88.
ModBase	Search...
Protein-protein interaction databases
STRING	Q0SX88.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBESCT00000095010; EBESCP00000091206; EBESCG00000094054.
GeneID	4208608.
GenomeReviews	Gene locus SFV_4353 in contig CP000266_GR.
KEGG	sfv:SFV_4353.
PATRIC	18733043. VBIShiFle33408_4940.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG3623.
GeneTree	EBGT00050000009562.
HOGENOM	HBG296694.
OMA	VVKARDW.
ProtClustDB	PRK13209.
Enzyme and pathway databases
BioCyc	SFLE373384:SFV_4353-MONOMER.
Family and domain databases
HAMAP	MF_01951. UlaE. [Tree]
InterPro	IPR004560. Hxl6Piso_put. IPR023492. Ribulose_5P_epimerase. IPR013022. Xyl_isomerase-like_TIM-brl. IPR012307. Xyl_isomerase_TIM-brl. [Graphical view]
Gene3D	G3DSA:3.20.20.150. Xyl_isomerase-like_TIM-brl. 1 hit.
KO	K03079.
Pfam	PF01261. AP_endonuc_2. 1 hit. [Graphical view]
SUPFAM	SSF51658. Xyl_isomerase-like_TIM-brl. 1 hit.
TIGRFAMs	TIGR00542. Hxl6Piso_put. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ULAE_SHIF8

Accession

Primary (citable) accession number: Q0SX88

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	September 5, 2006
Last modified:	January 25, 2012
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program