Q0SWK5 (OTC_CLOPS) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ornithine carbamoyltransferase
Short name=OTCase
EC=2.1.3.3

Gene names

Name:	arcB
Ordered Locus Names:	CPR_0158

Organism

Clostridium perfringens (strain SM101 / Type A) [Complete proteome] [HAMAP]

Taxonomic identifier

289380 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Clostridia › Clostridiales › Clostridiaceae › Clostridium

Protein attributes

Sequence length	331 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Carbamoyl phosphate + L-ornithine = phosphate + L-citrulline. HAMAP MF_01109
Pathway	Amino-acid degradation; L-arginine degradation via ADI pathway; carbamoyl phosphate from L-arginine: step 2/2. HAMAP MF_01109
Subcellular location	Cytoplasm Probable HAMAP MF_01109.
Sequence similarities	Belongs to the ATCase/OTCase family.

Ontologies

Keywords
Biological process	Arginine metabolism
Cellular component	Cytoplasm
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine metabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	ornithine carbamoyltransferase complex Inferred from electronic annotation. Source: InterPro
Molecular function	amino acid binding Inferred from electronic annotation. Source: InterPro ornithine carbamoyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 331	331	Ornithine carbamoyltransferase HAMAP MF_01109		PRO_1000065090
Regions
	Region	57 – 61	5	Carbamoyl phosphate binding By similarity
	Region	271 – 274	4	Ornithine binding By similarity
Sites
	Binding site	106	1	Carbamoyl phosphate By similarity
	Binding site	133	1	Carbamoyl phosphate By similarity
	Site	32	1	Important for structural integrity By similarity
	Site	146	1	Important for structural integrity By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q0SWK5 [UniParc]. Last modified September 5, 2006. Version 1. Checksum: 0D9C566B48DB4180	FASTA	331	37,125
	10 20 30 40 50 60 MAVNLKGRSF LTLKDFTPAE IRYLLDLSHD LKAKKRAGIL GDSLKGKNVV LLFEKTSTRT 70 80 90 100 110 120 RCAFECGAAE EGAHVTFLTN SQMGKKESIE DTAKVLGRMY DGIEFRGFKQ STVEELAKHA 130 140 150 160 170 180 GVPVWNGLTD ADHPTQILAD FLTIEEHAHK PLSEIKLVFT GDTRNNMSYA LMYGAAKMGM 190 200 210 220 230 240 HFVALGPDSL KPDEDILKEM QEYSKETGAT IEFSSNVDEA VKGADVIYTD IWVSMGEDES 250 260 270 280 290 300 LYPERVKLLT PYKVTREMMN KTGNKNTLFM HCLPSFHDED TEVCKDMMDR LGLDIREVED 310 320 330 EVFRSKNSVV FDEAENRMHT IKAVMVATAG K

References

[1]

"Skewed genomic variability in strains of the toxigenic bacterial pathogen, Clostridium perfringens." Myers G.S.A., Rasko D.A., Cheung J.K., Ravel J., Seshadri R., DeBoy R.T., Ren Q., Varga J., Awad M.M., Brinkac L.M., Daugherty S.C., Haft D.H., Dodson R.J., Madupu R., Nelson W.C., Rosovitz M.J., Sullivan S.A., Khouri H. , Dimitrov G.I., Watkins K.L., Mulligan S., Benton J., Radune D., Fisher D.J., Atkins H.S., Hiscox T., Jost B.H., Billington S.J., Songer J.G., McClane B.A., Titball R.W., Rood J.I., Melville S.B., Paulsen I.T. Genome Res. 16:1031-1040(2006) [PubMed: 16825665] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SM101 / Type A.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000312 Genomic DNA. Translation: ABG85583.1.
RefSeq	YP_697495.1. NC_008262.1.
3D structure databases
ProteinModelPortal	Q0SWK5.
SMR	Q0SWK5. Positions 1-328.
ModBase	Search...
Protein-protein interaction databases
STRING	Q0SWK5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4205070.
GenomeReviews	Gene locus CPR_0158 in contig CP000312_GR.
KEGG	cpr:CPR_0158.
PATRIC	19488591. VBICloPer122123_0143.
TIGR	CPR_0158.
Phylogenomic databases
eggNOG	COG0078.
HOGENOM	HBG579429.
OMA	MTPYQIN.
ProtClustDB	PRK04284.
Enzyme and pathway databases
BioCyc	CPER289380:CPR_0158-MONOMER.
Family and domain databases
HAMAP	MF_01109. OTCase. [Tree]
InterPro	IPR006132. Asp/Orn_carbamoyltranf_P-bd. IPR006130. Asp/Orn_carbamoylTrfase. IPR006131. Asp_carbamoyltransf_Asp/Orn-bd. IPR002292. Orn/put_carbamltrans. IPR024904. Orn_carbamltrans. [Graphical view]
KO	K00611.
Pfam	PF00185. OTCace. 1 hit. PF02729. OTCace_N. 1 hit. [Graphical view]
PRINTS	PR00100. AOTCASE. PR00102. OTCASE.
SUPFAM	SSF53671. Asp/Orn_carbamoyltranf. 1 hit.
TIGRFAMs	TIGR00658. Orni_carb_tr. 1 hit.
PROSITE	PS00097. CARBAMOYLTRANSFERASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

OTC_CLOPS

Accession

Primary (citable) accession number: Q0SWK5

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	September 5, 2006
Last modified:	January 25, 2012
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program